Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.760 | GeneticVariation | BEFREE | The cumulative effects test of risk alleles (rs rs1983891, rs339331, rs16901966, rs1447295 and rs10090154) showed an increasing risk to PCa in a frequency-dependent manner (ptrend=0.001), and men with more than 3 risk alleles had the most significant susceptibility to PCa (OR=1.99, p=0.001), compared with those who had one risk allele (OR=1.17, p=0.486). | 26537068 | 2016 |
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0.760 | GeneticVariation | BEFREE | To validate this approach, we analyzed the 6q22.1 prostate cancer risk locus and identified rs339331 as the top-scoring SNP. | 26398868 | 2015 |
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0.760 | GeneticVariation | BEFREE | Together, our results suggest that rs339331 affects prostate cancer risk by altering RFX6 expression through a functional interaction with the prostate cancer susceptibility gene HOXB13. | 24390282 | 2014 |
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0.760 | GeneticVariation | BEFREE | Other SNPs were not significantly associated with clinical covariates in prostate cancer (P > 0.05).CONCLUSIONS. rs339331</span> in the RFX6 gene may be associated with prostate cancer as a susceptibility locus in northern Chinese men. | 23803082 | 2013 |
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0.760 | GeneticVariation | BEFREE | We found that three of the five genetic variants were associated with prostate cancer risk (P = 4.33 × 10(-8) for rs12653946 at 5p15, 4.43 × 10(-5) for rs339331 at 6q22 and 8.42 × 10(-4) for rs9600079 at 13q22, respectively). | 22114074 | 2012 |
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0.760 | GeneticVariation | BEFREE | We successfully replicated the association of rs13385191 (located in the C2orf43 gene, P = 8.60×10(-5)), rs12653946 (P = 1.33×10(-6)), rs1983891 (FOXP4, P = 6.22×10(-5)), and rs339331 (GPRC6A/RFX6, P = 1.42×10(-5)) with prostate cancer. | 22662242 | 2012 |