|
rs1695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the present study we investigated the association of a number of polymorphic changes in antioxidant system genes (SNPs rs1050450 in the GPX1 gene, rs1695 and rs1138272 in the GSTP1 gene and rs4880 in the MnSOD gene) with the risk of prostate cancer.
|
24610081 |
2014 |
|
rs1695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, a study with the larger sample size is needed to further evaluate gene-environment interaction on GSTP1 Ile105Val polymorphisms and PCa risk.
|
23494181 |
2013 |
|
rs1695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the stratified analysis by ethnicity, significant associations between GSTP1 Ile105Val polymorphism and PC</span>a risk were also found among Caucasians for Val/Val vs Ile/Ile comparison (OR = 1.22; I(2) = 0.0 %; 95 % CI = 1.02-1.47) and for the recessive model (OR = 1.26; I(2) = 0.0%; 95% CI = 1.06-1.49), while there were no associations found for other genetic models.
|
23843029 |
2013 |
|
rs1695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis showed that GSTP1 Ile105Val polymorphism might not be significantly associated with overall prostate cancer risk.
|
23977100 |
2013 |
|
rs1695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate the GSTP1 Ile105Val genotype frequency in prostate cancer cases in the Kashmiri population, we designed a case-control study, in which 50 prostate cancer cases and 45 benign prostate hyperplasia cases were studied for GSTP1 Ile105Val polymorphism, compared to 80 controls taken from the general population, employing the PCR-RFLP technique.
|
22180037 |
2011 |
|
rs1695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no effect modification of glucosinolate intake and cancer risk by GSTA1 (G-52A) or GSTP1 (A313G) genotype, but serum glutathione S-transferase-alpha concentrations were inversely associated with prostate cancer.
|
20056632 |
2010 |
|
rs1695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
It has been postulated that individuals with GSTM1, GSTT1 deficiency and, GSTP1 (105Ile/Val transition) have increased susceptibility to carcinogens and are more likely to develop prostate cancer.
|
19143011 |
2009 |
|
rs1695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We evaluated potential associations between smoking and polymorphisms in PAH metabolism [CYP1A1 Ile 462Val, CYP1B1 Ala 119Ser and Leu 432Val, microsomal epoxide hydrolase (mEH) Tyr 113His and His139Arg, CYP3A4 A(-392)G] and conjugation [glutathione S-transferase (GST) M1 null deletion, GSTP1 Ile 105Val] genes and PAH-DNA adduct levels (measured by immunohistochemistry) in tumor and nontumor prostate cells in 400 prostate cancer cases.
|
17548691 |
2007 |
|
rs1695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The glutathione S-transferase (GST) enzymes detoxify several carcinogens and genetic polymorphisms in GSTM1, T1, and P1 (Ile105Val) have been reported to be associated with prostate cancer, mainly from blood samples.
|
17059341 |
2007 |
|
rs1695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association of occupational PAH exposure and GSTP1 Ile105Val</span> polymorphism with prostate cancer was tested in multiple logistic regression models adjusting for potential confounders.
|
17067754 |
2006 |
|
rs1695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To investigate this, we studied the association between prostate cancer and smoking, as well as the main and modifying effects of functional polymorphisms in genes that metabolize polycyclic aromatic hydrocarbons (CYP1A1 Ile(462)Val, microsomal epoxide hydrolase His(139)Arg) and detoxify reactive derivatives (GSTM1 null deletion, GSTT1 null deletion, GSTP1 Ile(105)Val and Ala(114)Val) using a family-based case-control design (439 prostate cancer cases and 479 brother controls).
|
16614120 |
2006 |
|
rs1695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found no significant association between the GSTP1 I105V polymorphism and familial or sporadic PCa when compared to the control group [odds ratio (OR) =1.0 (0.74-1.37); P=0.58].
|
15527908 |
2004 |
|
rs1695
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Glutathione S-transferase P1 Ile105Val polymorphism, cigarette smoking and prostate cancer.
|
15542263 |
2004 |
|
rs1138272
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the present study we investigated the association of a number of polymorphic changes in antioxidant system genes (SNPs rs1050450 in the GPX1 gene, rs1695 and rs1138272 in the GSTP1 gene and rs4880 in the MnSOD gene) with the risk of prostate cancer.
|
24610081 |
2014 |
|
rs1138272
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To investigate this, we studied the association between prostate cancer and smoking, as well as the main and modifying effects of functional polymorphisms in genes that metabolize polycyclic aromatic hydrocarbons (CYP1A1 Ile(462)Val, microsomal epoxide hydrolase His(139)Arg) and detoxify reactive derivatives (GSTM1 null deletion, GSTT1 null deletion, GSTP1 Ile(105)Val and Ala(114)Val) using a family-based case-control design (439 prostate cancer cases and 479 brother controls).
|
16614120 |
2006 |
|
rs1394960893
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study showed that the inverse association between glucosinolate intake and prostate cancer risk was modified by NQO1 (C609T) and GSTM1 and GSTT1 deletion polymorphisms.
|
20056632 |
2010 |