Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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|
T | 0.740 | GeneticVariation | GWASCAT | Association analysis identifies 65 new breast cancer risk loci. | 29059683 | 2017 |
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0.740 | GeneticVariation | BEFREE | For BRCA1 mutation carriers, there was a statistically significant inverse association of the K3326X variant with risk of ovarian cancer (HR = 0.43, 95% CI = 0.22 to 0.84, P = .013) but no association with breast cancer. | 26586665 | 2016 |
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|
T | 0.740 | GeneticVariation | GWASCAT | Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. | 27197191 | 2016 |
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|
0.740 | GeneticVariation | BEFREE | Despite classification of the BRCA2c.9976A>T, p.(Lys3326Ter) variant as a polymorphism, it has been associated with increased risks of pancreatic, lung, oesophageal and breast cancer. | 26041759 | 2015 |
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|
0.740 | GeneticVariation | BEFREE | This data is consistent with recent iCOGs data suggesting that this variant is not neutral with respect to breast cancer risk. rs11571833 may need to be included in SNP panels for evaluating breast cancer risk. | 26455428 | 2015 |
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|
T | 0.740 | GeneticVariation | GWASCAT | Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. | 25751625 | 2015 |
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|
0.740 | GeneticVariation | BEFREE | A rare truncating BRCA2 genetic variant, rs11571833 (K3326X), has been associated with a 2.5-fold risk of lung squamous cell carcinoma but only a modest 26% increase in breast cancer risk. | 25838448 | 2015 |
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T | 0.740 | GeneticVariation | GWASCAT | Large-scale genotyping identifies 41 new loci associated with breast cancer risk. | 23535729 | 2013 |