rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In summary, our findings suggested that the rs2046210 polymorphism may serve as a potential genetic biomarker of BC in both Asians and Caucasians.
|
30693664 |
2019 |
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Significant associations with BC were observed for rs3803662 (dominant comparison: OR, 0.89; 95% CI, 0.84-0.95; P = .0008; recessive comparison: OR, 1.17; 95% CI, 1.07-1.28; P = .0004; over-dominant comparison: OR, 1.07; 95% CI, 1.02-1.11; P = .002; allele comparison: OR, 0.90; 95% CI, 0.86-0.95; P = .0002), rs8051542 (dominant comparison: OR, 0.87; 95% CI, 0.83-0.91; P < .0001; recessive comparison: OR, 1.19; 95% CI, 1.11-1.28; P < .0001; over-dominant comparison: OR, 1.07; 95% CI, 1.02-1.11; P = .004; allele comparison: OR, 0.89; 95% CI, 0.86-0.91; P < .0001), and rs12922061 (dominant comparison: OR, 0.83; 95% CI, 0.73-0.93; P = .002; over-dominant comparison: OR, 1.43; 95% CI, 1.27-1.61; P < .0001) polymorphisms in the overall population.
|
31324582 |
2019 |
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
TOX3-rs3803662, may confer some degrees of risk of breast cancer in Iranian population.
|
30515698 |
2019 |
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
SNP rs3803662 (TOX3/TNRC9) is an independent prognostic factor for breast cancer in Henan Han Population.
|
31317673 |
2019 |
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Given that <i>TOX3</i> mRNA is a target of miR-182, and that both the <i>TOX3</i> rs3803662-T and pri-miR-182 rs4541843-T alleles are associated with increased BC risk, we evaluated their combined effect.
|
30135399 |
2018 |
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
No statistically significant association was found between the rs3803662 polymorphism and breast cancer in patients or healthy controls.
|
29683073 |
2018 |
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis suggested that TOX3 rs3803662 polymorphism was associated with increased breast cancer risk.
|
29578175 |
2018 |
rs17879961
|
|
G |
0.900 |
GeneticVariation |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
BC patients (n = 1687) randomly sampled in an adjuvant, randomized phase III trial (SUCCESS A study) were genotyped for nine BC risk SNPs: rs17468277 <i>(CASP8)</i> , rs2981582 <i>(FGFR2)</i> , rs13281615(8q24), rs3817198 <i>(LSP1)</i> , rs889312 <i>(MAP3K1)</i> , rs3803662 <i>(TOX3)</i> , rs13387042(2q35), rs4973768 <i>(SLC4A7)</i> , rs6504950 <i>(COX11)</i> .
|
28757652 |
2017 |
rs17879961
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We analyzed the association between p.</span>I157T and the clinico-pathological breast cancer characteristics by comparing the p.I157T carrier tumors to non-carrier and c.1100delC carrier tumors.
|
27716369 |
2016 |
rs17879961
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A Comparison between CHEK2*1100delC/I157T Mutation Carrier and Noncarrier Breast Cancer Patients: A Clinicopathological Analysis.
|
26991782 |
2016 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The other two SNPs (rs2046210 and rs3734805) were strongly associated with susceptibility to breast cancer.
|
27525837 |
2016 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In a genome-wide association study conducted among Chinese women, we identified the single nucleotide polymorphism (SNP) rs2046210 at 6q25.1 for breast cancer risk.
|
26645718 |
2016 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The genotype of rs2046210 (6q25.1), rs2981582 (EGFR2), rs889312 (MAP3K1), and rs3803662 (TOX3/TNRC9) has no statistical differences in different subtypes of breast cancer.
|
26803517 |
2016 |
rs2046210
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci.
|
27354352 |
2016 |
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The present meta-analysis suggests that rs3803662 polymorphism is significantly associated with breast cancer risk in Caucasian women, and we did not find the association in Asian women.
|
27350156 |
2016 |
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A case‑control study (90‑100 cases; 90‑100 controls) was performed to evaluate five genetic variants of three genes, including FGFR2 (SNPs: rs1219648, rs2981582), TNRC9 (SNPs: rs8051542, rs3803662) and MAP3K1 (SNP: rs889312) as BC risk factors in Pakistani women.
|
27572905 |
2016 |
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Five common breast cancer susceptibility loci from GWAS are not strongly associated with breast cancer risk among the Han Chinese of the Henan province; only rs3803662 (T</span>OX3/TNRC9) is confirmed to increase the risk of breast cancer.
|
26803517 |
2016 |
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The TNRC9 rs3803662 C>T polymorphism is greatly related to increased risk of BC, in both Asian and Caucasian populations.
|
27525937 |
2016 |
rs3803662
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Subjects carrying an allele of rs2981582 had reduced breast cancer risk (GA vs GG: OR=0.444, 95% CI=0.262-0.752; AA vs GG: OR=0.579, 95% CI=0.342-0.983). rs3803662 and rs3817198 SNPs did not significantly differ between cases and controls (P=0.408 and 0.116, respectively).
|
26911390 |
2016 |
rs17879961
|
|
G |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
|
25751625 |
2015 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Furthermore, C6ORF97 showed significant worse prognostic values especially in luminal B subtype in the publically available data sets. rs2046210 and the upstream gene C6ORF97 might have substantial roles not only in carcinogenesis but also in progression toward a more aggressive phenotype in breast cancer patients, which suggests that functional studies of this locus are imperative.
|
25370037 |
2015 |
rs2046210
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
|
25751625 |
2015 |
rs2046210
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Five of the 17 SNPs were significantly associated (P ≤ 0.05) with overall breast cancer in the same direction as previously reported: rs13387042 (2q35/TNP1), rs4973768 (3p24/SLC4A7), rs2046210 (6q25/ESR1), rs1219648 (10q26/FGFR2), and rs4784227 (16q12/TOX3).
|
24510657 |
2015 |
rs3803662
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
|
25751625 |
2015 |