Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1044396
rs1044396
0.010 GeneticVariation BEFREE Gene polymorphisms of CHRNA3 (rs578776) and CHRNA4 (rs1044396 and rs2229959) were associated with the success of smoking cessation after the diagnosis of lung cancer, which should be considered in the management of smoking cessation after patients are diagnosed with lung cancer. 31402126

2020

dbSNP: rs121912654
rs121912654
0.010 GeneticVariation BEFREE The lung-enriched p53 mutants V157F and R158L/P regulate a gain of function transcriptome in lung cancer. 31067569

2020

dbSNP: rs139600787
rs139600787
0.010 GeneticVariation BEFREE Among all lung cancer-linked mutants that we tested, A46T Parkin failed to translocate onto mitochondria and could not recruit downstream mitophagic regulators, including optineurin (OPTN) and TFEB, whereas N254S and R275W Parkin displayed slower mitochondrial translocation than WT Parkin. 31285534

2020

dbSNP: rs2229959
rs2229959
0.010 GeneticVariation BEFREE Gene polymorphisms of CHRNA3 (rs578776) and CHRNA4 (rs1044396 and rs2229959) were associated with the success of smoking cessation after the diagnosis of lung cancer, which should be considered in the management of smoking cessation after patients are diagnosed with lung cancer. 31402126

2020

dbSNP: rs2239611
rs2239611
0.010 GeneticVariation BEFREE These findings suggested that rs2284749 and rs2239611 in the ST6GAL1 gene are associated with lung carcinoma risk in the Chinese Han population. 31794515

2020

dbSNP: rs2284749
rs2284749
0.010 GeneticVariation BEFREE These findings suggested that rs2284749 and rs2239611 in the ST6GAL1 gene are associated with lung carcinoma risk in the Chinese Han population. 31794515

2020

dbSNP: rs483352697
rs483352697
0.010 GeneticVariation BEFREE The lung-enriched p53 mutants V157F and R158L/P regulate a gain of function transcriptome in lung cancer. 31067569

2020

dbSNP: rs756402191
rs756402191
0.010 GeneticVariation BEFREE The lung-enriched p53 mutants V157F and R158L/P regulate a gain of function transcriptome in lung cancer. 31067569

2020

dbSNP: rs776983107
rs776983107
0.010 GeneticVariation BEFREE Among all lung cancer-linked mutants that we tested, A46T Parkin failed to translocate onto mitochondria and could not recruit downstream mitophagic regulators, including optineurin (OPTN) and TFEB, whereas N254S and R275W Parkin displayed slower mitochondrial translocation than WT Parkin. 31285534

2020

dbSNP: rs778009684
rs778009684
0.010 GeneticVariation BEFREE Among all lung cancer-linked mutants that we tested, A46T Parkin failed to translocate onto mitochondria and could not recruit downstream mitophagic regulators, including optineurin (OPTN) and TFEB, whereas N254S and R275W Parkin displayed slower mitochondrial translocation than WT Parkin. 31285534

2020

dbSNP: rs10053847
rs10053847
0.010 GeneticVariation BEFREE <i>IL-7R</i> rs10053847 was correlated with a decreased LC risk, while <i>IL-7R</i> rs10213865 was correlated with an elevated lung adenocarcinoma risk, implying these two SNPs might play essential roles in LC risk evaluation. 31354347

2019

dbSNP: rs10054203
rs10054203
0.010 GeneticVariation BEFREE Four polymorphisms exhibited prominent associations with lung cancer risk, including rs7726159 (OR = 1.34, 95%CI: 1.18-1.52, P = 7.78 × 10<sup>-6</sup> ), rs10054203 (OR = 1.29, 95%CI: 1.13-1.46, P = 1.37 × 10<sup>-4</sup> ), rs2736107 (OR = 1.28, 95%CI: 1.11-1.47, P = 5.14 × 10<sup>-4</sup> ), and rs2853677 (OR = 1.23, 95%CI: 1.08-1.39, P = 0.002). 30680798

2019

dbSNP: rs10213865
rs10213865
0.010 GeneticVariation BEFREE <i>IL-7R</i> rs10053847 was correlated with a decreased LC risk, while <i>IL-7R</i> rs10213865 was correlated with an elevated lung adenocarcinoma risk, implying these two SNPs might play essential roles in LC risk evaluation. 31354347

2019

dbSNP: rs1026411
rs1026411
0.010 GeneticVariation BEFREE In this study, we chose four single nucleotide polymorphisms (SNPs) in lncRNA-<i>PCAT1</i> (rs1026411 G>A, rs12543663 A>C, rs710886 T>C, and rs16901904 T>C) to investigate the association between genetic variant in lncRNA-<i>PCAT1</i> and susceptibility to lung cancer. 31464517

2019

dbSNP: rs10421768
rs10421768
0.010 GeneticVariation BEFREE However, rs10421768 in HAMP showed a borderline statistically significant correlation with lung cancer risk (OR = 2.83, p = 0.05). 30640897

2019

dbSNP: rs1042711
rs1042711
0.010 GeneticVariation BEFREE Genetic model analysis shows that rs1042711 and rs1560642 were associated with increased risk of lung cancer; whereas rs7025417, rs5756523, and rs2284033 were associated with decreased disease risk (p < 0.05). 31685439

2019

dbSNP: rs1043994
rs1043994
0.010 GeneticVariation BEFREE In conclusion, the rs3815188 variant and rs1043994 variant of the Notch3 gene is associated with lung cancer risk in patients of Turkish origin. 30806291

2019

dbSNP: rs1046175
rs1046175
0.010 GeneticVariation BEFREE This study aims to explore the relationship between SFTPB rs7316, rs9752 and PAOX rs1046175 gene polymorphisms and the diagnostic value of plasma Pro-SFTPB and DAS in patients with Chinese Han lung cancer. 31016788

2019

dbSNP: rs10519717
rs10519717
0.010 GeneticVariation BEFREE Additionally, rs1489759 and rs3131837 were associated with lung cancer in various genetic models. rs1489758, rs1489759, and rs10519717 were also associated with lung cancer in serious COPD patients. 29915314

2019

dbSNP: rs1057519784
rs1057519784
ALK
0.010 GeneticVariation BEFREE In this study, we report that both <i>ALK</i>-mutant L1196M and EMT were concomitantly detected in a single crizotinib-resistant lesion in a patient with <i>ALK</i>-rearranged lung cancer. 30737231

2019

dbSNP: rs1064607
rs1064607
LPP
0.010 GeneticVariation BEFREE In stratified analyses by gender, three (rs1064607, rs3796283 and rs2378456) of LPP gene were associated with a significantly increased susceptibility for lung cancer among male population. 30621612

2019

dbSNP: rs1065852
rs1065852
0.010 GeneticVariation BEFREE This study revealed that rs1065852, rs2043449, rs2762s934, and rs6068816 of CYPs were associated with LC susceptibility in the Northwestern Chinese Han population; CYP2D6 and CYP20A1 were overexpressed and correlated with prognosis of LC. 31264381

2019

dbSNP: rs10680577
rs10680577
0.010 GeneticVariation BEFREE The Ins/Del polymorphism (rs10680577) in RERT-lncRNA was correlated with the risk, major clinicopathological features, and prognosis of lung cancer patients, and the patients with Ins/Del + Del/Del genotype carriers had higher expressions of RERT-lncRNA and EGLN2 than those with Ins/Ins carriers. 30073577

2019

dbSNP: rs11137037
rs11137037
0.010 GeneticVariation BEFREE Carriers of the variant GT allele of rs12674822 had a higher risk of lung cancer than wild-type (GG) carriers, while the presence of the CC genotype at rs11137037 was associated with higher clinical stage disease compared with having the AA genotype. 31281470

2019

dbSNP: rs1128503
rs1128503
0.010 GeneticVariation BEFREE The rs1799971 and rs1323040 polymorphisms of the <i>OPRM1</i> gene and rs2032582 and rs1128503 polymorphisms of the <i>ABCB1</i> gene are related to the analgesic effect and consumed dose of sufentanil in Chinese Han patients undergoing radical operation of lung cancer. 30455395

2019