Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1051730
rs1051730
0.900 GeneticVariation GWASDB Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. 22899653

2013

dbSNP: rs1051730
rs1051730
0.900 GeneticVariation BEFREE The nicotinic acetylcholine receptor polymorphism (rs1051730) on chromosome 15q25 is associated with major tobacco-related diseases in the general population with additional increased risk of COPD as well as lung cancer. 23061658

2013

dbSNP: rs1051730
rs1051730
0.900 GeneticVariation BEFREE The CHRNA3 rs1051730 polymorphism has been associated to chronic obstructive pulmonary disease (COPD), lung cancer and nicotine dependence in case-control studies with high smoking exposure; however, its influence on lung function and COPD severity in the general population is largely unknown. 22441734

2013

dbSNP: rs1051730
rs1051730
0.900 GeneticVariation BEFREE We also investigated the relationship between the rs1051730 SNP in an intron of the CHRNA3 gene (the polymorphism most significantly associated with lung cancer risk and smoking behavior) and TSD. 21645942

2012

dbSNP: rs1051730
rs1051730
0.900 GeneticVariation BEFREE Our findings demonstrated that CHRNA3 gene rs1051730-A allele and AGPHD1 gene rs8034191-T allele might be risk-conferring factors for the development of lung cancer in Caucasians, but not in East-Asians. 22701590

2012

dbSNP: rs1051730
rs1051730
0.900 GeneticVariation BEFREE Associations of SNPs in LOC123688 (rs10519203; odds ratio [OR] = 1.60, 95% confidence interval [CI] = 1.25 to 2.05, P = .00016), CHRNA5 (rs2036527; OR = 1.67, 95% CI = 1.26 to 2.21, P = .00031), and CHRNA3 (rs1051730; OR = 1.81, 95% CI = 1.26 to 2.59, P = .00137) genes with lung cancer risk reached Bonferroni-corrected levels of statistical significance (all statistical tests were two-sided). 20554942

2010

dbSNP: rs1051730
rs1051730
0.900 GeneticVariation BEFREE Similarly, neither CHRNA3 rs8034191 nor rs1051730 were associated with lung cancer risk. 20068085

2010

dbSNP: rs1051730
rs1051730
0.900 GeneticVariation BEFREE Smoking behavior and COPD are mediators of the association between the single nucleotide polymorphism (SNP) rs1051730 and the risk of lung cancer. 20564069

2010

dbSNP: rs1051730
rs1051730
0.900 GeneticVariation BEFREE In the chr15q25.1 region spanning the nicotinic receptors CHRNA3 and CHRNA5, we identified multiple SNPs associated with CPD (p<10(-3)), including rs1051730, which has been associated with nicotine dependence, smoking intensity and lung cancer risk. 19247474

2009

dbSNP: rs1051730
rs1051730
0.900 GeneticVariation GWASDB Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. 19654303

2009

dbSNP: rs1051730
rs1051730
0.900 GeneticVariation GWASCAT Lung cancer susceptibility locus at 5p15.33. 18978790

2008

dbSNP: rs1051730
rs1051730
0.900 GeneticVariation BEFREE We used urinary biomarkers to test whether two linked lung cancer risk variants in CHRNA3 (rs1051730) and CHRNA5 (rs16969968) are associated with intensity of smoking and exposure to a tobacco-specific carcinogenic nitrosamine per cigarette dose. 19010884

2008

dbSNP: rs1051730
rs1051730
0.900 GeneticVariation GWASDB Lung cancer susceptibility locus at 5p15.33. 18978790

2008

dbSNP: rs1051730
rs1051730
0.900 GeneticVariation GWASDB Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. 18385676

2008

dbSNP: rs1051730
rs1051730
0.900 GeneticVariation BEFREE The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. 18780872

2008

dbSNP: rs1051730
rs1051730
0.900 GeneticVariation GWASDB A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. 18385738

2008

dbSNP: rs1051730
rs1051730
0.900 GeneticVariation GWASDB Common 5p15.33 and 6p21.33 variants influence lung cancer risk. 18978787

2008

dbSNP: rs2736100
rs2736100
0.890 GeneticVariation BEFREE We then found that GRSs used as instrumental variables to predict longer telomere length were associated with increased lung cancer risk (OR = 1.51 (95% CI = 1.34-1.69) for upper vs. lower quartile of the weighted GRS, p value = 4.54 × 10(-14) ) even after removing rs2736100 (p value = 4.81 × 10(-3) ), a SNP in the TERT locus robustly associated with lung cancer risk in prior association studies. 25516442

2015

dbSNP: rs2736100
rs2736100
0.890 GeneticVariation BEFREE Increased lung cancer risk associated with the TERT rs2736100 polymorphism: an updated meta-analysis. 24590268

2014

dbSNP: rs2736100
rs2736100
0.890 GeneticVariation BEFREE TERT rs2736100 polymorphism contributes to lung cancer risk: a meta-analysis including 49,869 cases and 73,464 controls. 24535778

2014

dbSNP: rs2736100
rs2736100
0.890 GeneticVariation BEFREE Association between TERT rs2736100 polymorphism and lung cancer susceptibility: evidence from 22 case-control studies. 24390616

2014

dbSNP: rs2736100
rs2736100
0.890 GeneticVariation GWASDB Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. 22899653

2013

dbSNP: rs2736100
rs2736100
0.890 GeneticVariation GWASCAT Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. 23143601

2013

dbSNP: rs2736100
rs2736100
0.890 GeneticVariation GWASDB Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. 23143601

2013

dbSNP: rs2736100
rs2736100
0.890 GeneticVariation BEFREE Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China. 23555636

2013