|
rs2555639
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our data suggest that the rs2555639 T allele is associated with increased risk of colon cancer, and that carriers of this risk allele exhibit decreased expression of 15-PGDH in the colon.
|
23717544 |
2013 |
|
rs2555639
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our data suggested that the rs2555639 T allele is associated with increased risk of metastasis of colon cancer, which can be used as an indicator for colon cancer metastasis.
|
31646799 |
2020 |
|
rs12527379
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The other six SNPs (rs1931002, rs9493150, rs12526196, rs12527705, rs9399005 and rs12527379) exhibited no significant difference in the genotype and allele frequencies between patients diagnosed with colon carcinoma and the normal healthy population.
|
25502877 |
2015 |
|
rs1365611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the first two stages, three SNPs (rs1365611, rs6844282 and rs2332897) were statistically significant (p<0.05) in combined analysis of association with risk of colon cancer and of association with 15-PGDH expression, after adjustment for multiple testing.
|
23717544 |
2013 |
|
rs16892766
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 927 MMR gene mutation carriers (360 MLH1, 442 MSH2, 85 MSH6 and 40 PMS2) from 315 families enrolled in the Colon Cancer Family Registry, were genotyped for the single nucleotide polymorphisms (SNPs): rs16892766 (8q23.3), rs6983267 (8q24.21), rs719725 (9p24), rs10795668 (10p14), rs3802842 (11q23.1), rs4444235 (14q22.2), rs4779584 (15q13.3), rs9929218 (16q22.1), rs4939827 (18q21.1), rs10411210 (19q13.1) and rs961253 (20p12.3).
|
23434150 |
2013 |
|
rs2332897
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the first two stages, three SNPs (rs1365611, rs6844282 and rs2332897) were statistically significant (p<0.05) in combined analysis of association with risk of colon cancer and of association with 15-PGDH expression, after adjustment for multiple testing.
|
23717544 |
2013 |
|
rs2770150
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, the rs2770150 is associated with colon cancer in women aged over 50 years and is closely linked with the decreased levels of female sex hormones during the post-menopausal period (OR = 0.188, CI: 0.074-0.48, P = <0.00084). rs10759932 and rs4986790 appear to have any association with colon cancer.
|
26771524 |
2016 |
|
rs2853668
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TERT-CLPTM1L rs2853668 interacted significantly with aspirin/NSAID use, where those with the AA genotype had a much lower risk of colon cancer when using aspirin/NSAIDs than those with the other genotypes.
|
22351525 |
2013 |
|
rs3093075
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CRP rs1205 AA genotype was associated with an increased risk of colon cancer (OR 1.3, 95%CI 1.1-1.7), whereas the rs3093075 A allele was associated with a reduced risk of rectal cancer (OR 0.7, 95%CI 0.5-0.9).
|
20949557 |
2011 |
|
rs4444235
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 927 MMR gene mutation carriers (360 MLH1, 442 MSH2, 85 MSH6 and 40 PMS2) from 315 families enrolled in the Colon Cancer Family Registry, were genotyped for the single nucleotide polymorphisms (SNPs): rs16892766 (8q23.3), rs6983267 (8q24.21), rs719725 (9p24), rs10795668 (10p14), rs3802842 (11q23.1), rs4444235 (14q22.2), rs4779584 (15q13.3), rs9929218 (16q22.1), rs4939827 (18q21.1), rs10411210 (19q13.1) and rs961253 (20p12.3).
|
23434150 |
2013 |
|
rs4779584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 927 MMR gene mutation carriers (360 MLH1, 442 MSH2, 85 MSH6 and 40 PMS2) from 315 families enrolled in the Colon Cancer Family Registry, were genotyped for the single nucleotide polymorphisms (SNPs): rs16892766 (8q23.3), rs6983267 (8q24.21), rs719725 (9p24), rs10795668 (10p14), rs3802842 (11q23.1), rs4444235 (14q22.2), rs4779584 (15q13.3), rs9929218 (16q22.1), rs4939827 (18q21.1), rs10411210 (19q13.1) and rs961253 (20p12.3).
|
23434150 |
2013 |
|
rs6844282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the first two stages, three SNPs (rs1365611, rs6844282 and rs2332897) were statistically significant (p<0.05) in combined analysis of association with risk of colon cancer and of association with 15-PGDH expression, after adjustment for multiple testing.
|
23717544 |
2013 |
|
rs6854845
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs6854845 was suggested to be a risk of colon cancer in human population.
|
31078271 |
2019 |
|
rs719725
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 927 MMR gene mutation carriers (360 MLH1, 442 MSH2, 85 MSH6 and 40 PMS2) from 315 families enrolled in the Colon Cancer Family Registry, were genotyped for the single nucleotide polymorphisms (SNPs): rs16892766 (8q23.3), rs6983267 (8q24.21), rs719725 (9p24), rs10795668 (10p14), rs3802842 (11q23.1), rs4444235 (14q22.2), rs4779584 (15q13.3), rs9929218 (16q22.1), rs4939827 (18q21.1), rs10411210 (19q13.1) and rs961253 (20p12.3).
|
23434150 |
2013 |
|
rs961253
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 927 MMR gene mutation carriers (360 MLH1, 442 MSH2, 85 MSH6 and 40 PMS2) from 315 families enrolled in the Colon Cancer Family Registry, were genotyped for the single nucleotide polymorphisms (SNPs): rs16892766 (8q23.3), rs6983267 (8q24.21), rs719725 (9p24), rs10795668 (10p14), rs3802842 (11q23.1), rs4444235 (14q22.2), rs4779584 (15q13.3), rs9929218 (16q22.1), rs4939827 (18q21.1), rs10411210 (19q13.1) and rs961253 (20p12.3).
|
23434150 |
2013 |
|
rs997476
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IκBKβ's rs6474387 (C>T intron 20) and rs11986055 (A>C intron 2) showed substantially lower colon cancer risk among current NSAID users (P(interaction) = 0.01 and P(interaction) = 0.045, respectively), whereas NFκB1's rs230490 (G>A 5' (outside UTR)) and rs997476 (C>A 3' (outside UTR)) showed higher CRC risk among current NSAID users (P(interaction) = 0.01 and P(interaction) = 0.03, respectively).
|
23002237 |
2013 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
MDR1 C3435T polymorphism influences the development of colon cancer and adult acute myeloid leukemia by the association with transporting carcinogen.
|
18644389 |
2008 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Genetic testing for C3435T MDR1 gene polymorphism may be a suitable test to evaluate the risk for colon cancer in patients under 50 years of age.
|
15912392 |
2005 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The present study suggests that MDR1 2677G>T and 3435C>T polymorphism is not a risk factor for sporadic colon cancer among Bulgarians and that somatic mutation at these sites is not involved in the genesis of colon tumors.
|
17674045 |
2008 |
|
rs1045642
|
|
|
0.040 |
GeneticVariation |
BEFREE |
G2677T and C3435T polymorphisms are not associated with colon cancer risk and prognosis in a selected patient population.
|
19192650 |
2009 |
|
rs2032582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
G2677T and C3435T polymorphisms are not associated with colon cancer risk and prognosis in a selected patient population.
|
19192650 |
2009 |
|
rs41395947
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, for variant G128C, there was no significant association with the risk of developing colon cancer.
|
30834416 |
2019 |
|
rs41494447
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Novel association between heterozygous genotype of single nucleotide polymorphism C218T in drug transporter ABCC1 gene and increased risk of colon cancer.
|
30834416 |
2019 |
|
rs8086
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that rs8086 of ACSL1 could be a promising prognostic marker in CC patients, reinforcing the relevance of LM in the progression of CC.
|
27992526 |
2016 |
|
rs3811802
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ADH1B rs3811802 and ADH1C rs4147542 significantly modified the alcohol-colon cancer association in women.
|
29390059 |
2018 |