rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We reproducibly associate higher expression of the ligand-receptor axis of TFF2 and CXCR4 with BRAF V600E-mutant colon cancer (P = 3.0 × 10(-3) and 0.077, respectively for TCGA; P = 3.0 × 10(-8) and 5.1 × 10(-7) for CIT).
|
25899003 |
2015 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, our findings suggest that targeting ErbB-3 receptors could represent an effective therapeutic approach in BRAF-V600E mutant colon cancer.
|
26160848 |
2015 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
KRAS and BRAF (V600E) mutations are important predictive and prognostic markers, respectively, in colon cancer, but little is known about patient and clinical factors associated with them.
|
24925349 |
2014 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF V600E was associated with advanced TNM (P < 0.001), more distant metastases (P = 0.025), and worse overall survival (OS, P < 0.001; multivariate HR = 4.2, P = 0.004) in colon cancer patients.
|
25367198 |
2014 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Detection of the BRAF V600E mutation in colon carcinoma: critical evaluation of the imunohistochemical approach.
|
24832158 |
2014 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MSI and the BRAF(V600E) mutation have a prognostic impact in colon cancer.
|
24964758 |
2014 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF V600E was associated with advanced TNM (P < 0.001), more distant metastases (P = 0.025), and worse overall survival (OS, P < 0.001; multivariate HR = 4.2, P = 0.004) in colon cancer patients.
|
25367198 |
2014 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MSI and the BRAF(V600E) mutation have a prognostic impact in colon cancer.
|
24964758 |
2014 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Detection of the BRAF V600E mutation in colon carcinoma: critical evaluation of the imunohistochemical approach.
|
24832158 |
2014 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
KRAS and BRAF (V600E) mutations are important predictive and prognostic markers, respectively, in colon cancer, but little is known about patient and clinical factors associated with them.
|
24925349 |
2014 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Sorafenib and cetuximab therapy led to a mixed radiographic response with some areas showing dramatic improvement and other areas showing stable disease over a 7-month period which is a notably long period of progression-free survival for V600E BRAF mutated colon cancer.
|
23792568 |
2013 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Herein, we present the case of a patient with bulky V600E-mutant BRAF hepatic flexure colon carcinoma, treated initially with FOLFOX plus bevacizumab neoadjuvant therapy and surgery.
|
23792567 |
2013 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Female patients and older group harbored a higher KRAS mutation (P = 0.018 and P = 0.031, respectively); BRAF (V600E) mutation showed a higher frequency in colon cancer and poor differentiation tumors (P = 0.020 and P = 0.030, respectively); proximal tumors appeared a higher PIK3CA mutation (P<0.001) and distant metastatic tumors shared a higher NRAS mutation (P = 0.010).
|
24339949 |
2013 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The clinical studies in the manuscript by Al-Marrawi et al. describe the rational combination of signaling inhibitors in a colon cancer patient whose tumor cells express a mutant active B-RAF V600E protein that signals into the MEK1/2-ERK1/2 pathway downstream of K-RAS; this is a particularly aggressive form of colon cancer for which few rational therapeutic interventions have been available until recent times.
|
24025253 |
2013 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The clinical studies in the manuscript by Al-Marrawi et al. describe the rational combination of signaling inhibitors in a colon cancer patient whose tumor cells express a mutant active B-RAF V600E protein that signals into the MEK1/2-ERK1/2 pathway downstream of K-RAS; this is a particularly aggressive form of colon cancer for which few rational therapeutic interventions have been available until recent times.
|
24025253 |
2013 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Sorafenib and cetuximab therapy led to a mixed radiographic response with some areas showing dramatic improvement and other areas showing stable disease over a 7-month period which is a notably long period of progression-free survival for V600E BRAF mutated colon cancer.
|
23792568 |
2013 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Herein, we present the case of a patient with bulky V600E-mutant BRAF hepatic flexure colon carcinoma, treated initially with FOLFOX plus bevacizumab neoadjuvant therapy and surgery.
|
23792567 |
2013 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Female patients and older group harbored a higher KRAS mutation (P = 0.018 and P = 0.031, respectively); BRAF (V600E) mutation showed a higher frequency in colon cancer and poor differentiation tumors (P = 0.020 and P = 0.030, respectively); proximal tumors appeared a higher PIK3CA mutation (P<0.001) and distant metastatic tumors shared a higher NRAS mutation (P = 0.010).
|
24339949 |
2013 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.
|
22281684 |
2012 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, this same agent does not generally benefit colon cancer patients who have the BRAF(V600E) mutation.
|
23074264 |
2012 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A set of 668 stage II and III CC samples from the PETACC-3 (Pan-European Trails in Alimentary Tract Cancers) clinical trial were used to assess differential gene expression between c.1799T>A (p.V600E) BRAF mutant and non-BRAF, non-KRAS mutant cancers (double wild type) and to construct a gene expression-based classifier for detecting BRAF mutant samples with high sensitivity.
|
22393095 |
2012 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A set of 668 stage II and III CC samples from the PETACC-3 (Pan-European Trails in Alimentary Tract Cancers) clinical trial were used to assess differential gene expression between c.1799T>A (p.V600E) BRAF mutant and non-BRAF, non-KRAS mutant cancers (double wild type) and to construct a gene expression-based classifier for detecting BRAF mutant samples with high sensitivity.
|
22393095 |
2012 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, this same agent does not generally benefit colon cancer patients who have the BRAF(V600E) mutation.
|
23074264 |
2012 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.
|
22281684 |
2012 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An interaction was observed between the MTHFR C677T polymorphism and freshwater fish consumption on colon cancer risk (P value for interaction = 0.031).
|
20551579 |
2010 |