|
rs3781264
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Recently, a genome-wide association study of gastric cancer (GC) reported the significant association of seven genetic variants (rs4072037 and rs4460629 on 1q22; rs753724, rs11187842, rs3765524, rs2274223, and rs3781264 on 10q23) with GC in a Chinese population.
|
22740136 |
2012 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results showed that the minor alleles of rs3765524, rs2274223, and rs10509670 were associated with increased risk of EC and GC.
|
30931333 |
2019 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings indicated that the PLCE1 rs2274223 variant might serve as a promising genetic biomarker of esophageal and gastric cancer in East Asians.
|
30784231 |
2019 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Collectively, this meta-analysis demonstrated that <i>CTLA-4</i> rs5742909 and <i>PLCE1</i> rs2274223 polymorphisms may confer susceptibility to GC, especially for East Asians.
|
31767616 |
2019 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results of subgroup analysis showed that the rs2274223 polymorphism was associated with higher risk for esophageal cancer and gastric cancer relative to colorectal cancer and head and neck cancer.
|
30619753 |
2018 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic variants of rs2274223 in PLCE1 at 10q23.33 (per G allele: odds ratio (OR) = 1.26, 95% confidence interval (CI): 1.16-1.38, P = 6.51 × 10<sup>-8</sup>), rs10052657 in PDE4D at 5q11.2 (per C allele: OR = 1.12, 95% CI: 1.01-1.25, P = 3.28 × 10<sup>-2</sup>) and rs671 in ALDH2 at 12q24.12 (per A-allele: OR = 0.83, 95% CI: 0.75-0.91, P = 1.14 × 10<sup>-4</sup>) were significantly associated with GC risk.
|
30202044 |
2018 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that rs2274223 A>G in PLCE1 was associated with increased GC survival in both training set (P = .011), which was independently replicated in validation set 1 (P = .045), but not in validation set 2.
|
29983348 |
2018 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Specifically, a significant increased stomach cancer risk was associated with PSCA rs2294008 (CT vs. CC: adjusted OR = 1.37, 95% CI = 1.07-1.74, and CT/TT vs.CC: adjusted OR = 1.30, 95% CI = 1.03-1.63), PSCA rs2976392 (AG vs. GG: adjusted OR = 1.30, 95% CI = 1.02-1.65, and AG/AA vs. GG: adjusted OR = 1.26, 95% CI = 1.00-1.59), or PLCE1 rs2274223 (AG vs. AA: adjusted OR = 1.48, 95% CI = 1.15-1.90, and AG/GG vs. AA: adjusted OR = 1.45, 95% CI = 1.14-1.84), respectively.
|
25658482 |
2015 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to determine whether rs4072037A > G in MUC1 at 1q22 and rs2274223A > G in PLCE1 at 10q23 are associated with a risk of gastric cancer in a Korean population.
|
24254309 |
2014 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings demonstrate that the presence of the G allele at rs2274223 of the PLCE1 gene may contribute to susceptibility to GC, especially cardia GC.
|
24985593 |
2014 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MUC1 rs4072037 allele G was protective against development of GC (OR=0.64, p=0.0005), while no differences were found for PLCE1 rs2274223.
|
25503145 |
2014 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Compared with the rs2274223 AA genotype, we found a significant association between the rs2274223 AG genotype and a weakly reduced risk of gastric cancer (OR = 0.87; 95% CI = 0.76-0.99 for AG vs AA).
|
24254309 |
2014 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These findings indicate that the three SNPs (rs4072037, rs13361707 and rs2274223) identified in the GWASs may interact with H. pylori infection to increase the risk of GC.
|
24069371 |
2013 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this meta-analysis, the PLCE1 rs2274223 polymorphism was confirmed to have a statistically significant association with an increasing risk of ESCC and gastric cancer.
|
23826241 |
2013 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, a genome-wide association study of gastric cancer (GC) reported the significant association of seven genetic variants (rs4072037 and rs4460629 on 1q22; rs753724, rs11187842, rs3765524, rs2274223, and rs3781264 on 10q23) with GC in a Chinese population.
|
22740136 |
2012 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We hypothesized that the single nucleotide polymorphism (SNP) rs2274223 A/G is associated with the survival rate of gastric cancer.
|
21837401 |
2011 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that rs4072037 at 1q22 and rs2274223 at 10q23 were significantly associated with risk of GC with per allele odds ratio (OR) of 0.72 [95% confidence interval (CI): 0.63-0.81; P = 2.98 × 10(-7)] and 1.42 (95% CI: 1.27-1.58; P = 9.68 × 10(-10)), respectively.
|
21427165 |
2011 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 x 10(-9); per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10(-9); OR = 1.34).
|
20729852 |
2010 |
|
rs3765524
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Results showed that the minor alleles of rs3765524, rs2274223, and rs10509670 were associated with increased risk of EC and GC.
|
30931333 |
2019 |
|
rs11187842
|
|
|
0.020 |
GeneticVariation |
BEFREE |
PLCE1 rs753724 and rs11187842 are associated with GC risk under the heterozygote model.
|
24985593 |
2014 |
|
rs753724
|
|
|
0.020 |
GeneticVariation |
BEFREE |
PLCE1 rs753724 and rs11187842 are associated with GC risk under the heterozygote model.
|
24985593 |
2014 |
|
rs11187842
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Recently, a genome-wide association study of gastric cancer (GC) reported the significant association of seven genetic variants (rs4072037 and rs4460629 on 1q22; rs753724, rs11187842, rs3765524, rs2274223, and rs3781264 on 10q23) with GC in a Chinese population.
|
22740136 |
2012 |
|
rs3765524
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Recently, a genome-wide association study of gastric cancer (GC) reported the significant association of seven genetic variants (rs4072037 and rs4460629 on 1q22; rs753724, rs11187842, rs3765524, rs2274223, and rs3781264 on 10q23) with GC in a Chinese population.
|
22740136 |
2012 |
|
rs753724
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Recently, a genome-wide association study of gastric cancer (GC) reported the significant association of seven genetic variants (rs4072037 and rs4460629 on 1q22; rs753724, rs11187842, rs3765524, rs2274223, and rs3781264 on 10q23) with GC in a Chinese population.
|
22740136 |
2012 |
|
rs10509670
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results showed that the minor alleles of rs3765524, rs2274223, and rs10509670 were associated with increased risk of EC and GC.
|
30931333 |
2019 |