|
rs11247957
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Herein, we evaluated the correlation of four potentially functional LIN28A SNPs (rs3811464 G>A, rs3811463 T>C, rs34787247 G>A, and rs11247957 G>A) and neuroblastoma susceptibility in 505 neuroblastoma patients and 1070 controls from four independent hospitals in China.
|
31747721 |
2020 |
|
rs2273267
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further independent case-control studies with functional analysis are needed to verify the role of NRAS gene rs2273267 A>T polymorphism in the risk of neuroblastoma.
|
31759987 |
2020 |
|
rs34787247
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, our finding indicated that LIN28A SNPs, especially rs34787247 G>A, may increase neuroblastoma risk.
|
31747721 |
2020 |
|
rs3811463
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Herein, we evaluated the correlation of four potentially functional LIN28A SNPs (rs3811464 G>A, rs3811463 T>C, rs34787247 G>A, and rs11247957 G>A) and neuroblastoma susceptibility in 505 neuroblastoma patients and 1070 controls from four independent hospitals in China.
|
31747721 |
2020 |
|
rs3811464
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Herein, we evaluated the correlation of four potentially functional LIN28A SNPs (rs3811464 G>A, rs3811463 T>C, rs34787247 G>A, and rs11247957 G>A) and neuroblastoma susceptibility in 505 neuroblastoma patients and 1070 controls from four independent hospitals in China.
|
31747721 |
2020 |
|
rs1024611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Dual-luciferase reporter assays were conducted in neuroblastoma cells to assess the promoter transcriptional activity of the rs1024611 variants (T>C) and the GRCh38.p12chr17:34252593 G>C alleles in CCL2.
|
30761072 |
2019 |
|
rs1052536
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that rs1052536 C>T and rs4796030 A>C are unrelated to neuroblastoma susceptibility in the Chinese population.
|
31737108 |
2019 |
|
rs11103603
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Maternal rs6776706 was associated with (RR: 0.49; 95% CI: 0.33-0.72, Q = 0.161) high-risk neuroblastoma and maternal rs11103603 (RR: 0.60; 95% CI: 0.45-0.79, Q = 0.127) was associated with neuroblastoma aged <1 year.
|
31279991 |
2019 |
|
rs1130409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we conducted a three-center case-control study to evaluate the association between <i>APEX1</i> polymorphisms (rs1130409 T>G, rs1760944 T>G, and rs3136817 T>C) and neuroblastoma risk in Chinese children, consisting of 469 cases and 998 controls.
|
31341530 |
2019 |
|
rs1131691014
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, we confirmed that miR-34b/c rs4938723 and TP53 Arg72Pro conferred decreased neuroblastoma risk and two polymorphisms exerted stronger protective effects against neuroblastoma than either one alone.
|
31325764 |
2019 |
|
rs121909536
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We generated SH-SY5Y neuroblastoma cell lines constitutively expressing wild type (WT) Hemagglutinin (HA) epitope tagged mouse Ang1 (mAng1), and two amyotrophic lateral sclerosis associated ANG variants (C39W and K40I).
|
31128105 |
2019 |
|
rs121909539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We generated SH-SY5Y neuroblastoma cell lines constitutively expressing wild type (WT) Hemagglutinin (HA) epitope tagged mouse Ang1 (mAng1), and two amyotrophic lateral sclerosis associated ANG variants (C39W and K40I).
|
31128105 |
2019 |
|
rs12442054
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One maternal SNP (rs12442054) was associated with decreased risk of neuroblastoma (RR: 0.61; 95% Confidence Interval (CI): 0.47-0.79, Q = 0.076).
|
31279991 |
2019 |
|
rs12587
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conducted a four-center case-control study to explore the association between <i>KRAS</i> gene polymorphisms (rs12587 G>T, rs7973450 A>G, rs7312175 G>A) and neuroblastoma susceptibility with 505 Chinese children and 1070 matched controls.
|
31564912 |
2019 |
|
rs1362575880
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The effects of these two mutations on presenilin-1 endoproteolysis and β-amyloid (Aβ) production were examined in SH-SY5Y neuroblastoma cells infected with lentiviruses expressing presenilin-1 wild type (WT), I249L and P433S mutants.
|
31235249 |
2019 |
|
rs17487792
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjusted gender and age, seven out of eleven SNPs in <i>BARD1</i> were significant associated with the risk of NB, including one SNP in 5'-UTR (rs17489363 G > A), two SNPs in exon (rs2229571 G > C and rs3738888 C > T), and four SNPs in intron (rs3768716 A > G, rs6435862 T > G, rs3768707 C > T and rs17487792 C > T).
|
31258718 |
2019 |
|
rs1760944
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we conducted a three-center case-control study to evaluate the association between <i>APEX1</i> polymorphisms (rs1130409 T>G, rs1760944 T>G, and rs3136817 T>C) and neuroblastoma risk in Chinese children, consisting of 469 cases and 998 controls.
|
31341530 |
2019 |
|
rs2153977
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In vitro and in silico analyses indicated that the rs2153977-T protective allele, located in an NB and CMM enhancer, decreased expression of SLC16A1 via long-range loop formation and altered a T-box protein binding site.
|
31605138 |
2019 |
|
rs28933981
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cytotoxicity assays revealed their toxicities in the order of Val30Met > Ala97Ser > WT > Thr119Met in neuroblastoma cells.
|
31728576 |
2019 |
|
rs3136817
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we conducted a three-center case-control study to evaluate the association between <i>APEX1</i> polymorphisms (rs1130409 T>G, rs1760944 T>G, and rs3136817 T>C) and neuroblastoma risk in Chinese children, consisting of 469 cases and 998 controls.
|
31341530 |
2019 |
|
rs3738888
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjusted gender and age, seven out of eleven SNPs in <i>BARD1</i> were significant associated with the risk of NB, including one SNP in 5'-UTR (rs17489363 G > A), two SNPs in exon (rs2229571 G > C and rs3738888 C > T), and four SNPs in intron (rs3768716 A > G, rs6435862 T > G, rs3768707 C > T and rs17487792 C > T).
|
31258718 |
2019 |
|
rs3768707
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjusted gender and age, seven out of eleven SNPs in <i>BARD1</i> were significant associated with the risk of NB, including one SNP in 5'-UTR (rs17489363 G > A), two SNPs in exon (rs2229571 G > C and rs3738888 C > T), and four SNPs in intron (rs3768716 A > G, rs6435862 T > G, rs3768707 C > T and rs17487792 C > T).
|
31258718 |
2019 |
|
rs4796030
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that rs1052536 C>T and rs4796030 A>C are unrelated to neuroblastoma susceptibility in the Chinese population.
|
31737108 |
2019 |
|
rs6776706
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Maternal rs6776706 was associated with (RR: 0.49; 95% CI: 0.33-0.72, Q = 0.161) high-risk neuroblastoma and maternal rs11103603 (RR: 0.60; 95% CI: 0.45-0.79, Q = 0.127) was associated with neuroblastoma aged <1 year.
|
31279991 |
2019 |
|
rs729147
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For gene-environment interaction, maternal rs729147 was associated with decreased risk of neuroblastoma among mothers with vitamin A consumption above the recommendation.
|
31279991 |
2019 |