DisGeNET - a database of gene-disease associations

ovarian neoplasm, C0919267

Gene: KRAS ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs121913529

KRAS

0.710

CausalMutation

CLINVAR

Epidermal growth factor receptor blockers for the treatment of ovarian cancer.

21975775

2011

dbSNP:

rs121913529

KRAS

0.710

CausalMutation

CLINVAR

Epidermal growth factor receptor blockers for the treatment of ovarian cancer.

21975775

2011

dbSNP:

rs121913529

KRAS

0.710

GeneticVariation

BEFREE

In vivo activity of combined PI3K/mTOR and MEK inhibition in a Kras(G12D);Pten deletion mouse model of ovarian cancer.

21632463

2011

dbSNP:

rs121913529

KRAS

0.710

CausalMutation

CLINVAR

Epidermal growth factor receptor blockers for the treatment of ovarian cancer.

21975775

2011

dbSNP:

rs121913529

KRAS

0.710

CausalMutation

CLINVAR

Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia.

19047918

2009

dbSNP:

rs121913529

KRAS

0.710

CausalMutation

CLINVAR

KRAS mutation analysis in ovarian samples using a high sensitivity biochip assay.

19358724

2009

dbSNP:

rs121913529

KRAS

0.710

CausalMutation

CLINVAR

KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer.

19018267

2008

dbSNP:

rs121913529

KRAS

0.710

CausalMutation

CLINVAR

KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer.

19018267

2008

dbSNP:

rs121913529

KRAS

0.710

CausalMutation

CLINVAR

Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia.

17910045

2008

dbSNP:

rs121913529

KRAS

0.710

CausalMutation

CLINVAR

KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer.

19018267

2008

dbSNP:

rs121913529

KRAS

0.710

CausalMutation

CLINVAR

Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations.

17332249

2007

dbSNP:

rs121913529

KRAS

0.710

CausalMutation

CLINVAR

KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib.

15696205

2005

dbSNP:

rs121913529

KRAS

0.710

CausalMutation

CLINVAR

Somatic PTPN11 mutations in childhood acute myeloid leukaemia.

15842656

2005

dbSNP:

rs112445441

KRAS

0.700

CausalMutation

CLINVAR

Epidermal growth factor receptor blockers for the treatment of ovarian cancer.

21975775

2011

dbSNP:

rs121913530

KRAS

0.700

CausalMutation

CLINVAR

Epidermal growth factor receptor blockers for the treatment of ovarian cancer.

21975775

2011

dbSNP:

rs121913530

KRAS

0.700

CausalMutation

CLINVAR

Epidermal growth factor receptor blockers for the treatment of ovarian cancer.

21975775

2011

dbSNP:

rs112445441

KRAS

0.700

CausalMutation

CLINVAR

KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer.

19018267

2008

dbSNP:

rs121913530

KRAS

0.700

CausalMutation

CLINVAR

KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer.

19018267

2008

dbSNP:

rs121913530

KRAS

0.700

CausalMutation

CLINVAR

KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer.

19018267

2008

dbSNP:

rs61764370

KRAS

0.030

GeneticVariation

BEFREE

Recently, a variant allele in the 3'UTR of the KRAS gene (rs61764370 T>G) was shown to be associated with an increased risk for developing non-small cell lung cancer, as well as ovarian cancer, and was most enriched in ovarian cancer patients from hereditary breast and ovarian cancer families.

20676756

2011

dbSNP:

rs61764370

KRAS

0.030

GeneticVariation

BEFREE

These data exclude the possibility of an association between rs61764370 and a clinically significant risk of ovarian cancer or of familial ovarian cancer.

21385923

2011

dbSNP:

rs61764370

KRAS

0.030

GeneticVariation

BEFREE

In this study, we investigated a hypothesized association between an increased risk of OC and a variant allele of KRAS at rs61764370, referred to as the KRAS-variant, which disrupts a let-7 miRNA binding site in this oncogene.

20647319

2010