|
rs1057519911
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The HNSCC cells with MAPK1 E322K exhibited enhanced EGFR phosphorylation and erlotinib sensitivity compared with wild-type MAPK1 cells.
|
26181029 |
2015 |
|
rs1057519991
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Combinations of the Y113H and H139R polymorphic EPHX1 variants have been assumed to alter the enzyme activity and thus the risk of squamous cell head and neck cancer (SCCHN).
|
12491039 |
2003 |
|
rs121912656
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We show here that overexpression of the GOF mutant p53 G245D and other GOF p53 mutants enhances the invasive cell growth of p53-deficient head and neck squamous cell carcinoma (HNSCC) UM-SCC-1 cells both in in vitro three-dimensional culture and in an in vivo orthotopic nude mouse model of HNSCC through a novel transcription-independent mechanism.
|
29269868 |
2018 |
|
rs121912666
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Our analysis of p53 in 10 additional HLA-A2(+) SCCHN tumors detected the p53 Y220C in 2/10 tumors raising the overall frequency of the p53 Y220C mutation to 6/50 (12%) HLA-A2(+) SCCHN tumors.
|
17294448 |
2007 |
|
rs121913483
|
|
|
0.710 |
GeneticVariation |
BEFREE |
PIK3CA showed a uniquely high rate of mutations within the helicase domain, and FGFR3 contained a predominance of hotspot S249C alterations that were not found in HPV- HNSCC.
|
30933315 |
2019 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In conclusion, the result from our study provides additional evidence of an association of the XRCC1 polymorphism (Arg194Trp) with SCCHN as markers of genetic susceptibility in the Korean population.
|
15252855 |
2004 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Finally, we identified the combined Arg194Trp-Arg399Arg genotype of base excision repair gene XRCC1 that was associated with HNSCC and may have an impact on identification of a high-risk cancer population.
|
19284666 |
2009 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
These results indicate that both Arg194Trp and Arg399Gln polymorphisms were not associated with the development of HNSCC in Turkish population.
|
26011347 |
2015 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In addition, the interaction of CYP2E1 (CYP2E1*5B and CYP2E1*6) with other genetic factors (null genotype of glutathione-S-Transferase M1, GSTM1, X-Ray Repair Cross Complementing Group I, XRCC1 (Arg194Trp), and environmental risk factors such as alcohol and tobacco in modifying HNSCC risk were investigated.
|
19334053 |
2009 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We evaluated the correlation of the x-ray repair cross complementing gene 1 (XRCC1) Arg194Trp polymorphism with clinical outcomes in head and neck squamous cell carcinoma (HNSCC) patients treated with concurrent chemoradiation therapy (CCRT).
|
29893275 |
2018 |
|
rs1799782
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In XRCC1 polymorphisms, Arg194Trp and Arg399Gln variants showed a reduced risk, whereas, XPD Lys751Gln variants exhibited ∼2-fold increase in SCCHN risk.
|
21945240 |
2012 |
|
rs1042522
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Stratification analyses showed that a reduced risk associated with the -606CC genotype was more pronounced in subgroups of non-smokers, non-drinkers, younger subjects (defined as ≤57 years), carriers of the TP53 Arg/Arg (rs1042522) genotype, patients with oropharyngeal cancer or late-stage SCCHN.
|
20935061 |
2010 |
|
rs1042522
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We found that RAD51 172TT homozygotes had a significantly decreased risk [adjusted odds ratio (OR) = 0.66, 95% confidence interval (CI) = 0.50-0.87] of SCCHN, compared with carriers of other genotypes, particularly in P53 Arg72Arg homozygotes (adjusted OR = 0.60, 95% CI = 0.41-0.89) (homogeneity test P = 0.047), although no alterations in the risk were associated with the RAD51 135G>C and P53 Arg72Pro SNPs.
|
17118968 |
2007 |
|
rs1042522
|
|
|
0.050 |
GeneticVariation |
BEFREE |
This study identified that individuals carrying the arginine allele at rs1042522 have an increased odds ratio of HNSCC.
|
26099726 |
2015 |
|
rs1042522
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Meta-analysis results indicated no association between p53 Arg72Pro polymorphism and the risk of HPV-related HNSCC: for Pro/Pro vs. Arg/Arg, OR = 1.17, 95% confidence interval (CI) = 0.70-1.98; for Arg/Pro vs. Arg/ Arg, OR = 1.25, 95% CI = 0.97-1.72; and for (Pro/Pro + Arg/Pro) vs. Arg/Arg, OR = 1.28, 95% CI = 0.95-1.70.
|
24289637 |
2013 |
|
rs1042522
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The meta-analysis showed no significant association between different allelic variants of Arg72Pro rs1042522 and SCCHN risk.
|
24370206 |
2014 |
|
rs1695
|
|
|
0.050 |
GeneticVariation |
BEFREE |
GSTM1, GSTT1 and GSTP1 Ile105Val polymorphisms in outcomes of head and neck squamous cell carcinoma patients treated with cisplatin chemoradiation.
|
31249357 |
2019 |
|
rs1695
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We hypothesized that head and neck squamous cell carcinoma (HNSCC) might respond differently to chemotherapeutic agents, especially cisplatin (CDDP) because of the presence of GSTP1 I105V polymorphism.
|
15254763 |
2004 |
|
rs1695
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We investigated the association between the occurrence of acute reactions in 101 patients with squamous cell carcinoma of the head and neck (SCCHN) after radiotherapy (RT) and five genetic polymorphisms: XRCC1 c.1196A>G, XRCC3 c.722C>T, RAD51 (c.-3429G>C, c.-3392G>T), and GSTP1 c.313A>G.
|
21704413 |
2011 |
|
rs1695
|
|
|
0.050 |
GeneticVariation |
BEFREE |
This large prospective cohort study supports a modestly increased risk of SPM after index SCCHN with GSTP1 Ile(105)Val polymorphism and an even greater risk of SPM with multiple combined GST risk genotypes.
|
19401526 |
2009 |
|
rs1695
|
|
|
0.050 |
GeneticVariation |
BEFREE |
ADH1B histidine allele (rs1229984), CYP2E1 rs3813867 heterozygous genotype, and GSTT1 deletion conferred protection against HNSCC (OR: 0.318 [0.04-0.75], OR: 0.13 [0.02-0.94], and OR: 0.12 [0.02-0.60], respectively) while GSTP1 (rs1695) Val/Val genotype was related to an increased risk (OR: 4.12 [1.11-15.31]).
|
25639971 |
2015 |
|
rs25487
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The findings indicated that a significantly decreased risk of SCCHN was associated with the ADPRT 762Ala/Ala genotype (adjusted odds ratio [OR], 0.51; 95% confidence interval [95% CI], 0.27-0.97) and the combined ADPRT 762Ala/Val and Ala/Ala genotypes (OR, 0.79; 95% CI; 0.63-1.00) compared with the ADPRT 762Val/Val genotype, but no altered risk was associated with the XRCC1 Arg399Gln or APE Asp148Glu polymorphisms, and no evidence of interactions was observed between the 3 selected SNPs and age, sex, smoking status, drinking status, or tumor site.
|
17614107 |
2007 |
|
rs25487
|
|
|
0.050 |
GeneticVariation |
BEFREE |
These results indicate that both Arg194Trp and Arg399Gln polymorphisms were not associated with the development of HNSCC in Turkish population.
|
26011347 |
2015 |
|
rs25487
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The results from this present meta-analysis suggest that XRCC1 Arg399Gln variants may contribute to HNSCC risk among Caucasians and to the risk of larynx squamous cell carcinoma.
|
24205020 |
2013 |
|
rs25487
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our findings showed an association between genetic polymorphisms, XRCC1 c.1196A>G and RAD51 c.-3429 G>C, and the development of radiation-induced toxicities in SCCHN patients.
|
21704413 |
2011 |