Gene: TP53 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11540652
rs11540652
TP53
T 0.700 CausalMutation CLINVAR

dbSNP: rs1042522
rs1042522
TP53
0.020 GeneticVariation BEFREE The mutation status of TP53 and expression of MDM2, TP53, and their genetic variants SNP309 and R72P (Arg72Pro) were investigated in 125 sarcoma patient samples and 18 sarcoma cell lines. 23165797

2013
dbSNP: rs1131691014
rs1131691014
TP53
0.020 GeneticVariation BEFREE The mutation status of TP53 and expression of MDM2, TP53, and their genetic variants SNP309 and R72P (Arg72Pro) were investigated in 125 sarcoma patient samples and 18 sarcoma cell lines. 23165797

2013
dbSNP: rs878854066
rs878854066
TP53
0.020 GeneticVariation BEFREE The mutation status of TP53 and expression of MDM2, TP53, and their genetic variants SNP309 and R72P (Arg72Pro) were investigated in 125 sarcoma patient samples and 18 sarcoma cell lines. 23165797

2013
dbSNP: rs1042522
rs1042522
TP53
0.020 GeneticVariation BEFREE The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is associated with risk of sarcomas: a meta-analysis. 22205265

2012
dbSNP: rs1131691014
rs1131691014
TP53
0.020 GeneticVariation BEFREE The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is associated with risk of sarcomas: a meta-analysis. 22205265

2012
dbSNP: rs762846821
rs762846821
TP53
0.020 GeneticVariation BEFREE In addition, using FSF-Kras(G12D/+); p53(FRT/FRT) mice, we demonstrate that an adenovirus expressing FlpO recombinase can initiate primary lung cancers and sarcomas in mice. p53(FRT) mice will enable dual recombinase technology to study cancer biology because Cre is available to modify genes specifically in stromal cells to investigate their role in tumor development, progression and response to therapy. 22228755

2012
dbSNP: rs878854066
rs878854066
TP53
0.020 GeneticVariation BEFREE The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is associated with risk of sarcomas: a meta-analysis. 22205265

2012
dbSNP: rs762846821
rs762846821
TP53
0.020 GeneticVariation BEFREE These results suggest that genomic alterations present in human MFH are conserved in the LSL-Kras(G12D); p53(Flox/Flox) mouse model of soft tissue sarcoma and demonstrate the utility of this pre-clinical model. 19956606

2009
dbSNP: rs1057519747
rs1057519747
TP53
0.010 GeneticVariation BEFREE Approximately 50% of the ovarian tumors in p53(wt/wt) mice and 23% in p53(Ala135Val/wt) mice are adenocarcinomas and the remaining tumors were adenocarcinoma mixed with sarcoma or ovarian sarcomas. 18234966

2008
dbSNP: rs121912665
rs121912665
TP53
0.010 GeneticVariation BEFREE Approximately 50% of the ovarian tumors in p53(wt/wt) mice and 23% in p53(Ala135Val/wt) mice are adenocarcinomas and the remaining tumors were adenocarcinoma mixed with sarcoma or ovarian sarcomas. 18234966

2008
dbSNP: rs1057519975
rs1057519975
TP53
0.010 GeneticVariation BEFREE Using three viral constructs containing cDNA for wild-type p53, mutant p53 (C135S) and lacZ, we studied the effect of adenoviral-mediated gene therapy in four pediatric sarcoma cell lines, RD and Rh4 (RMS), Rh1 (Ewing's sarcoma) and A204 (undifferentiated sarcoma). 15618970

2005