Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE We found that rs1006737 was associated with both schizophrenia (P(allele) = 0.0014, P(genotype) = 0.006, odds ratio (OR) = 1.384, 95% CI 1.134-1.690) and major depressive disorder (P(allele) = 0.0007, P(genotype) = 0.003, OR = 1.425, 95% CI 1.160-1.752). 24262814

2014

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be overrepresented in patients suffering from bipolar disorder, schizophrenia or major depression. 19781653

2010

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE The single nucleotide polymorphisms FKBP5:rs1360780, BDNF:rs6265 (Val66Met), P2RX7:2230912 (Gln460Arg) and CACNA1C:rs1006737 were genotyped in DNA from 457 depression cases (major depression, dysthymia, and mixed anxiety depression) and 2286 healthy controls with no symptom of psychopathology. 20226536

2010

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE The current data provide further evidence for an impact of rs1006737 on the left IFG and demonstrate that genetic variation in CACNA1C modulates neural responses in patients with MDD. 24612926

2014

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE The study population comprised 188 healthy first-degree relatives of patients with bipolar disorder (n=59), major depression (n=73), and schizophrenia (n=56) and 110 comparison subjects from our discovery study who were genotyped for rs1006737 and underwent functional magnetic resonance imaging while performing an episodic memory task and psychological testing. 24411473

2014

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder. 21078228

2011

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Though rs1006737 in the CACNA1C gene showed significant association with MDD in a British large-scale candidate association study, most of the replication analyses with relatively small sample size reported negative association. 27260792

2016

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression. 24643163

2014

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51). 21042317

2012

dbSNP: rs1006737
rs1006737
0.900 GeneticVariation BEFREE The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with schizophrenia and major depression. 21676128

2011

dbSNP: rs2535629
rs2535629
0.820 GeneticVariation BEFREE In the MDD-bipolar cross-disorder analysis, 15 SNPs exceeded genome-wide significance (P<5 × 10(-8)), and all were in a 248 kb interval of high LD on 3p21.1 (chr3:52 425 083-53 822 102, minimum P=5.9 × 10(-9) at rs2535629). 22472876

2013

dbSNP: rs2535629
rs2535629
0.820 GeneticVariation BEFREE The aim of the study was to replicate the association of rs2535629 with schizophrenia and major depressive disorder (MDD) in Japanese subjects. 24373612

2014

dbSNP: rs7647854
rs7647854
0.810 GeneticVariation BEFREE We identified one replicated genome-wide significant locus associated with adult-onset (>27 years) MDD (rs7647854, odds ratio: 1.16, 95% confidence interval: 1.11-1.21, p = 5.2 × 10<sup>-11</sup>). 27519822

2017

dbSNP: rs2522833
rs2522833
0.780 GeneticVariation BEFREE Although we did not take into account rare variants, we conclude that our results provide further support for the hypothesis that the non-synonymous coding SNP rs2522833 in the PCLO gene is indeed likely to be the causal variant in the GAIN-MDD cohort. 24278217

2013

dbSNP: rs2522833
rs2522833
0.780 GeneticVariation BEFREE Recent genetic studies showed evidence for a role of the single-nucleotide polymorphism rs2522833 within the PCLO gene in the etiology of major depression, and rs2522833 has been shown to modulate hypothalamic pituitary adrenal (HPA) axis activity during antidepressant treatment. 22832399

2011

dbSNP: rs2522833
rs2522833
0.780 GeneticVariation BEFREE Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression. 24643163

2014

dbSNP: rs2522833
rs2522833
0.780 GeneticVariation BEFREE PCLO rs2522833 modulates HPA system response to antidepressant treatment in major depressive disorder. 20701824

2011

dbSNP: rs2522833
rs2522833
0.780 GeneticVariation BEFREE A genome-wide association study implicated the polymorphism rs2522833 in the piccolo (PCLO) gene--involved in monoaminergic neurotransmission--as a risk factor for MDD. 22832909

2012

dbSNP: rs2522833
rs2522833
0.780 GeneticVariation BEFREE We conclude that PCLO SNP rs2522833 is associated with a gray matter volume reduction in the left temporal pole in drug-naive, first-episode patients with MDD carrying the C-allele. 28556829

2017

dbSNP: rs2522833
rs2522833
0.780 GeneticVariation BEFREE Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences. 26045179

2015

dbSNP: rs2522833
rs2522833
0.780 GeneticVariation BEFREE A recent genome-wide association study on Major Depressive Disorder (MDD) identified a specific association with a non-synonymous polymorphism (rs2522833) of a gene encoding the presynaptic protein piccolo (PCLO). 22386049

2012

dbSNP: rs12415800
rs12415800
0.720 GeneticVariation BEFREE A recent genome-wide association study (GWAS) for major depressive disorder (MDD) in Chinese women identified a single-nucleotide polymorphism (SNP), rs12415800, near the Sirtuin1 (SIRT1) gene as one of the top candidate loci. 31176830

2019

dbSNP: rs12415800
rs12415800
0.720 GeneticVariation BEFREE Besides, in independent Han Chinese postmortem brain and peripheral blood samples, the MDD risk allele of rs12415800 predicted lower SIRT1 mRNA levels, which was consistent with the reduced expression of this gene in MDD patients compared with healthy subjects. 31819045

2019

dbSNP: rs1545843
rs1545843
0.720 GeneticVariation BEFREE We observed an association between the SLC6A15 rs1545843 and resting-state brain function of the corpus callosum, cingulum and the frontal, parietal, and temporal lobes in MDD patients, which may be involved in the pathogenesis of MDD. 28915082

2017

dbSNP: rs1545843
rs1545843
0.720 GeneticVariation BEFREE We observed an association between the risk allele of the SLC6A15 gene rs1545843 and the WM integrity of the PHC in MDD patients, which is known to play an important role in the neural circuit involved in emotion processing. 27723767

2016