rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found that rs1006737 was associated with both schizophrenia (P(allele) = 0.0014, P(genotype) = 0.006, odds ratio (OR) = 1.384, 95% CI 1.134-1.690) and major depressive disorder (P(allele) = 0.0007, P(genotype) = 0.003, OR = 1.425, 95% CI 1.160-1.752).
|
24262814 |
2014 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be overrepresented in patients suffering from bipolar disorder, schizophrenia or major depression.
|
19781653 |
2010 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphisms FKBP5:rs1360780, BDNF:rs6265 (Val66Met), P2RX7:2230912 (Gln460Arg) and CACNA1C:rs1006737 were genotyped in DNA from 457 depression cases (major depression, dysthymia, and mixed anxiety depression) and 2286 healthy controls with no symptom of psychopathology.
|
20226536 |
2010 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The current data provide further evidence for an impact of rs1006737 on the left IFG and demonstrate that genetic variation in CACNA1C modulates neural responses in patients with MDD.
|
24612926 |
2014 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The study population comprised 188 healthy first-degree relatives of patients with bipolar disorder (n=59), major depression (n=73), and schizophrenia (n=56) and 110 comparison subjects from our discovery study who were genotyped for rs1006737 and underwent functional magnetic resonance imaging while performing an episodic memory task and psychological testing.
|
24411473 |
2014 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder.
|
21078228 |
2011 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Though rs1006737 in the CACNA1C gene showed significant association with MDD in a British large-scale candidate association study, most of the replication analyses with relatively small sample size reported negative association.
|
27260792 |
2016 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression.
|
24643163 |
2014 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51).
|
21042317 |
2012 |
rs1006737
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with schizophrenia and major depression.
|
21676128 |
2011 |
rs2535629
|
|
|
0.820 |
GeneticVariation |
BEFREE |
In the MDD-bipolar cross-disorder analysis, 15 SNPs exceeded genome-wide significance (P<5 × 10(-8)), and all were in a 248 kb interval of high LD on 3p21.1 (chr3:52 425 083-53 822 102, minimum P=5.9 × 10(-9) at rs2535629).
|
22472876 |
2013 |
rs2535629
|
|
|
0.820 |
GeneticVariation |
BEFREE |
The aim of the study was to replicate the association of rs2535629 with schizophrenia and major depressive disorder (MDD) in Japanese subjects.
|
24373612 |
2014 |
rs7647854
|
|
|
0.810 |
GeneticVariation |
BEFREE |
We identified one replicated genome-wide significant locus associated with adult-onset (>27 years) MDD (rs7647854, odds ratio: 1.16, 95% confidence interval: 1.11-1.21, p = 5.2 × 10<sup>-11</sup>).
|
27519822 |
2017 |
rs2522833
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Although we did not take into account rare variants, we conclude that our results provide further support for the hypothesis that the non-synonymous coding SNP rs2522833 in the PCLO gene is indeed likely to be the causal variant in the GAIN-MDD cohort.
|
24278217 |
2013 |
rs2522833
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Recent genetic studies showed evidence for a role of the single-nucleotide polymorphism rs2522833 within the PCLO gene in the etiology of major depression, and rs2522833 has been shown to modulate hypothalamic pituitary adrenal (HPA) axis activity during antidepressant treatment.
|
22832399 |
2011 |
rs2522833
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression.
|
24643163 |
2014 |
rs2522833
|
|
|
0.780 |
GeneticVariation |
BEFREE |
PCLO rs2522833 modulates HPA system response to antidepressant treatment in major depressive disorder.
|
20701824 |
2011 |
rs2522833
|
|
|
0.780 |
GeneticVariation |
BEFREE |
A genome-wide association study implicated the polymorphism rs2522833 in the piccolo (PCLO) gene--involved in monoaminergic neurotransmission--as a risk factor for MDD.
|
22832909 |
2012 |
rs2522833
|
|
|
0.780 |
GeneticVariation |
BEFREE |
We conclude that PCLO SNP rs2522833 is associated with a gray matter volume reduction in the left temporal pole in drug-naive, first-episode patients with MDD carrying the C-allele.
|
28556829 |
2017 |
rs2522833
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Functional characterization of the PCLO p.Ser4814Ala variant associated with major depressive disorder reveals cellular but not behavioral differences.
|
26045179 |
2015 |
rs2522833
|
|
|
0.780 |
GeneticVariation |
BEFREE |
A recent genome-wide association study on Major Depressive Disorder (MDD) identified a specific association with a non-synonymous polymorphism (rs2522833) of a gene encoding the presynaptic protein piccolo (PCLO).
|
22386049 |
2012 |
rs12415800
|
|
|
0.720 |
GeneticVariation |
BEFREE |
A recent genome-wide association study (GWAS) for major depressive disorder (MDD) in Chinese women identified a single-nucleotide polymorphism (SNP), rs12415800, near the Sirtuin1 (SIRT1) gene as one of the top candidate loci.
|
31176830 |
2019 |
rs12415800
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Besides, in independent Han Chinese postmortem brain and peripheral blood samples, the MDD risk allele of rs12415800 predicted lower SIRT1 mRNA levels, which was consistent with the reduced expression of this gene in MDD patients compared with healthy subjects.
|
31819045 |
2019 |
rs1545843
|
|
|
0.720 |
GeneticVariation |
BEFREE |
We observed an association between the SLC6A15 rs1545843 and resting-state brain function of the corpus callosum, cingulum and the frontal, parietal, and temporal lobes in MDD patients, which may be involved in the pathogenesis of MDD.
|
28915082 |
2017 |
rs1545843
|
|
|
0.720 |
GeneticVariation |
BEFREE |
We observed an association between the risk allele of the SLC6A15 gene rs1545843 and the WM integrity of the PHC in MDD patients, which is known to play an important role in the neural circuit involved in emotion processing.
|
27723767 |
2016 |