rs5569
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One hundred and five patients with major depression and 74 unrelated matched controls were analyzed for a silent 1287G/A polymorphism (NET-8) in exon 9 of the NET gene.
|
10512149 |
1999 |
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that the 102T/C polymorphism in 5-HT2A receptor gene is primarily associated with suicidal ideation in patients with major depression.Am.J. Med.Genet.(Neuropsychiatr.Genet.)96:56-60, 2000.
|
10686553 |
2000 |
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent studies have shown an association of allele C of the 5-HT2A-T102C polymorphism with suicidal ideation in patients with major depression.
|
11121191 |
2000 |
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The 102T/C polymorphism of the 5-HT(2A) receptor gene was analyzed in 159 patients with major depression (DSM-IV criteria) and 164 unrelated and healthy controls using a case control design.
|
11803534 |
2001 |
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined two polymorphisms in the serotonin-2A-receptor gene (5-HT2A; T102C and His452Tyr) and the insertion/deletion polymorphism in the promoter region of the serotonin transporter (5-HTTLPR) in a sample of 173 patients with major depression and 121 healthy controls.
|
11311507 |
2001 |
rs1805054
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The results of the association study provide that the 5-HT(6) C267T genetic variant does not play a major role in producing the clinical manifestations or antidepressant response for MDD patients.
|
11702016 |
2001 |
rs6314
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We examined two polymorphisms in the serotonin-2A-receptor gene (5-HT2A; T102C and His452Tyr) and the insertion/deletion polymorphism in the promoter region of the serotonin transporter (5-HTTLPR) in a sample of 173 patients with major depression and 121 healthy controls.
|
11311507 |
2001 |
rs5569
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a case control association study we investigated the newly identified T-182C polymorphism and an already known G1287A polymorphism in exon 9 of the NET gene in a sample of 193 patients with major depression and 136 healthy, non-related controls.
|
11927173 |
2002 |
rs1045642
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We examined this SNP in patients with major depression enrolled in a randomized antidepressant treatment trial of nortriptyline and fluoxetine, and observed a significant association between nortriptyline-induced postural hypotension and 3435C>T (chi(2) = 6.78, df = 2, P = 0.034).
|
12082591 |
2002 |
rs1415088003
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the angiotensin I converting enzyme (ACE) ID and the G-protein beta3-subunit (Gbeta3) C825T polymorphism in 201 patients with unipolar major depression and 161 ethnically and age-matched controls.
|
12476328 |
2002 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study tested the hypothesis that the BDNF-gene Val66Met polymorphism is associated with MDD, its clinical manifestations, and antidepressant response.
|
14582140 |
2003 |
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Many studies investigated the association between MDD and BD with the 5-HT2A 102 T/C, the 5-HTT promoter 44 bp insertion/deletion and the intron 2 VNTR polymorphisms, and thus, these could be pooled using meta-analytic techniques.
|
12851635 |
2003 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study tested the hypothesis that the BDNF-gene Val66Met polymorphism is associated with MDD, its clinical manifestations, and antidepressant response.
|
14582140 |
2003 |
rs6296
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism.
|
12496953 |
2003 |
rs6313
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additional evidence for a role of serotonin (5-HT) in the pathogenesis of suicidal behavior is provided by a recent report that the 5-HT2A (HTR2A) T102C polymorphism was associated with suicidality in patients with major depression.
|
15469201 |
2004 |
rs5443
|
|
|
0.090 |
GeneticVariation |
BEFREE |
These results suggest that the T allele of the C825T polymorphism in the GNB3 gene is associated with MDD.
|
14647404 |
2004 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There are no published reports of homocysteine levels and methylenetetrahydrofolate reductase (MTHFR) C677T genotype in clinical samples of patients with late-onset major depressive disorder (MDD).
|
16223965 |
2005 |
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study.
|
15583702 |
2005 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Haplotype analysis of marker combination rs988748-(GT)n-rs6265 produced nominally significant associations for all investigated phenotypes (global p values: MDD p = .00006, BPAD p = .0057, schizophrenia p = .016).
|
16005437 |
2005 |
rs1805054
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These findings imply that a 5-HT6 receptor polymorphism (C267T) is associated with treatment response in MDD.
|
15823158 |
2005 |
rs1352618632
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined patients with bipolar disorder (n = 171), major depressive disorder (n = 329) and controls (n = 351) in Japanese ethnicity for genetic association using eleven single nucleotide polymorphisms (SNPs), including a missense one (A2387G; N796S), in the genomic region of BCR.
|
15866548 |
2005 |
rs140504
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined patients with bipolar disorder (n = 171), major depressive disorder (n = 329) and controls (n = 351) in Japanese ethnicity for genetic association using eleven single nucleotide polymorphisms (SNPs), including a missense one (A2387G; N796S), in the genomic region of BCR.
|
15866548 |
2005 |
rs988748
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis of marker combination rs988748-(GT)n-rs6265 produced nominally significant associations for all investigated phenotypes (global p values: MDD p = .00006, BPAD p = .0057, schizophrenia p = .016).
|
16005437 |
2005 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder.
|
16979146 |
2006 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We genotyped the BDNF-gene Val66Met polymorphism in 110 elderly inpatients diagnosed with major depression and 171 age- and sex-similar control subjects.
|
16343697 |
2006 |