Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs5569
rs5569
0.100 GeneticVariation BEFREE One hundred and five patients with major depression and 74 unrelated matched controls were analyzed for a silent 1287G/A polymorphism (NET-8) in exon 9 of the NET gene. 10512149

1999

dbSNP: rs6313
rs6313
0.100 GeneticVariation BEFREE Our results suggest that the 102T/C polymorphism in 5-HT2A receptor gene is primarily associated with suicidal ideation in patients with major depression.Am.J. Med.Genet.(Neuropsychiatr.Genet.)96:56-60, 2000. 10686553

2000

dbSNP: rs6313
rs6313
0.100 GeneticVariation BEFREE Recent studies have shown an association of allele C of the 5-HT2A-T102C polymorphism with suicidal ideation in patients with major depression. 11121191

2000

dbSNP: rs6313
rs6313
0.100 GeneticVariation BEFREE The 102T/C polymorphism of the 5-HT(2A) receptor gene was analyzed in 159 patients with major depression (DSM-IV criteria) and 164 unrelated and healthy controls using a case control design. 11803534

2001

dbSNP: rs6313
rs6313
0.100 GeneticVariation BEFREE We examined two polymorphisms in the serotonin-2A-receptor gene (5-HT2A; T102C and His452Tyr) and the insertion/deletion polymorphism in the promoter region of the serotonin transporter (5-HTTLPR) in a sample of 173 patients with major depression and 121 healthy controls. 11311507

2001

dbSNP: rs1805054
rs1805054
0.020 GeneticVariation BEFREE The results of the association study provide that the 5-HT(6) C267T genetic variant does not play a major role in producing the clinical manifestations or antidepressant response for MDD patients. 11702016

2001

dbSNP: rs6314
rs6314
0.020 GeneticVariation BEFREE We examined two polymorphisms in the serotonin-2A-receptor gene (5-HT2A; T102C and His452Tyr) and the insertion/deletion polymorphism in the promoter region of the serotonin transporter (5-HTTLPR) in a sample of 173 patients with major depression and 121 healthy controls. 11311507

2001

dbSNP: rs5569
rs5569
0.100 GeneticVariation BEFREE In a case control association study we investigated the newly identified T-182C polymorphism and an already known G1287A polymorphism in exon 9 of the NET gene in a sample of 193 patients with major depression and 136 healthy, non-related controls. 11927173

2002

dbSNP: rs1045642
rs1045642
0.070 GeneticVariation BEFREE We examined this SNP in patients with major depression enrolled in a randomized antidepressant treatment trial of nortriptyline and fluoxetine, and observed a significant association between nortriptyline-induced postural hypotension and 3435C>T (chi(2) = 6.78, df = 2, P = 0.034). 12082591

2002

dbSNP: rs1415088003
rs1415088003
ACE
0.010 GeneticVariation BEFREE We investigated the angiotensin I converting enzyme (ACE) ID and the G-protein beta3-subunit (Gbeta3) C825T polymorphism in 201 patients with unipolar major depression and 161 ethnically and age-matched controls. 12476328

2002

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The present study tested the hypothesis that the BDNF-gene Val66Met polymorphism is associated with MDD, its clinical manifestations, and antidepressant response. 14582140

2003

dbSNP: rs6313
rs6313
0.100 GeneticVariation BEFREE Many studies investigated the association between MDD and BD with the 5-HT2A 102 T/C, the 5-HTT promoter 44 bp insertion/deletion and the intron 2 VNTR polymorphisms, and thus, these could be pooled using meta-analytic techniques. 12851635

2003

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The present study tested the hypothesis that the BDNF-gene Val66Met polymorphism is associated with MDD, its clinical manifestations, and antidepressant response. 14582140

2003

dbSNP: rs6296
rs6296
0.020 GeneticVariation BEFREE Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism. 12496953

2003

dbSNP: rs6313
rs6313
0.100 GeneticVariation BEFREE Additional evidence for a role of serotonin (5-HT) in the pathogenesis of suicidal behavior is provided by a recent report that the 5-HT2A (HTR2A) T102C polymorphism was associated with suicidality in patients with major depression. 15469201

2004

dbSNP: rs5443
rs5443
0.090 GeneticVariation BEFREE These results suggest that the T allele of the C825T polymorphism in the GNB3 gene is associated with MDD. 14647404

2004

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE There are no published reports of homocysteine levels and methylenetetrahydrofolate reductase (MTHFR) C677T genotype in clinical samples of patients with late-onset major depressive disorder (MDD). 16223965

2005

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study. 15583702

2005

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Haplotype analysis of marker combination rs988748-(GT)n-rs6265 produced nominally significant associations for all investigated phenotypes (global p values: MDD p = .00006, BPAD p = .0057, schizophrenia p = .016). 16005437

2005

dbSNP: rs1805054
rs1805054
0.020 GeneticVariation BEFREE These findings imply that a 5-HT6 receptor polymorphism (C267T) is associated with treatment response in MDD. 15823158

2005

dbSNP: rs1352618632
rs1352618632
0.010 GeneticVariation BEFREE We examined patients with bipolar disorder (n = 171), major depressive disorder (n = 329) and controls (n = 351) in Japanese ethnicity for genetic association using eleven single nucleotide polymorphisms (SNPs), including a missense one (A2387G; N796S), in the genomic region of BCR. 15866548

2005

dbSNP: rs140504
rs140504
0.010 GeneticVariation BEFREE We examined patients with bipolar disorder (n = 171), major depressive disorder (n = 329) and controls (n = 351) in Japanese ethnicity for genetic association using eleven single nucleotide polymorphisms (SNPs), including a missense one (A2387G; N796S), in the genomic region of BCR. 15866548

2005

dbSNP: rs988748
rs988748
0.010 GeneticVariation BEFREE Haplotype analysis of marker combination rs988748-(GT)n-rs6265 produced nominally significant associations for all investigated phenotypes (global p values: MDD p = .00006, BPAD p = .0057, schizophrenia p = .016). 16005437

2005

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder. 16979146

2006

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE We genotyped the BDNF-gene Val66Met polymorphism in 110 elderly inpatients diagnosed with major depression and 171 age- and sex-similar control subjects. 16343697

2006