|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To analyze the relationship of GSTT1, GSTM1, XRCC1 (rs25487), ERCC1 (rs11615, rs3212986), ERCC2 (rs13181), XRCC3 (rs861539), OGG1 (rs1052133), and Alpha-1-Antitrypsin mutations (AAT) with the risk of lung cancer in never-smokers, and ascertain if there is an effect modification between these polymorphisms and residential radon exposure.
|
31446980 |
2019 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Using the multifactor dimensionality reduction method, we found a model of gene-gene interactions associated with the risk of lung cancer: NBS1 (rs1805794)-XRCC1 (rs25487)-hOGG1 (rs1052133)-XPG (rs17655).
|
31584889 |
2019 |
|
rs25489
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated associations between the risk of lung cancer in residents of the coal-mining region and polymorphisms in the genes APEX1 (rs1130409), hOGG1 (rs1052133), XRCC1 (rs25489, rs25487), XRCC2 (rs3218536), XRCC3 (rs861539), ADPRT/PARP1 (rs1136410), XPD/ERCC2 (rs13181), XPG/ERCC5 (rs17655), XPC (rs2228001), ATM (rs1801516), and NBS1 (rs1805794).
|
31584889 |
2019 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CONCLUSIONS Taken together, T-77C and Arg399Gln polymorphisms of the XRCC1 gene, as well as the 186C>T and Val158Met polymorphisms of the COMT gene, increased the risk of lung cancer in non-smoking women, with the factors of occupation type, cooking-oil fumes, and soot exposures representing key contributing factors.
|
30109864 |
2018 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A significant association was found between SULT1A1 rs9282861 and XRCC1 rs25487 polymorphisms and lung cancer risk.
|
29110586 |
2017 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The analysis results showed that the following polymorphisms were correlated with susceptibility to lung cancer: rs4646903 in CYP1A1 (P < 0.001), rs1048943 in CYP1A1 (P < 0.001), rs1695 in GSTP1 (P < 0.05), rs13181 in ERCC2 (P < 0.001), and rs25487 in XRCC1 (P < 0.05); no such correlation existed in rs861539 in XRCC3 (P > 0.05).
|
27819744 |
2016 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Additionally, four polymorphisms of XRCC1 (rs25487, rs25489, rs1799782, and rs3213245), which were investigated with regard to their association with lung cancer risk in previous studies, were also genotyped.
|
25592768 |
2015 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, these preliminary results suggest that the C > T, rs1799782 and C > T, rs25487 of XRCC1 genetic variants might be used as molecular markers for detecting lung cancer susceptibility.
|
25563194 |
2015 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings indicated that certain XRCC1 Arg399Gln variants might affect the susceptibility of lung cancer in Chinese population.
|
25684477 |
2015 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data demonstrated that the SNPs rs25487</span> and rs1052133 are risk factors for l</span>ung cancer in epidemiologically susceptible Chinese people.
|
26634519 |
2015 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the present study, we investigated the polymorphisms of the following selected members of the base and nucleotide excision repair genes: XPC (Lys939Gln), XPD (Lys751Gln), XRCC1(Arg399Gln), and hOGG1(Ser326Ser), and the risk they present toward the development of lung cancer, with emphasis on the effect of chromium exposure.
|
25300687 |
2015 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, these preliminary results suggest that the C > T, rs1799782 and C > T, rs25487 of XRCC1 genetic variants might be used as molecular markers for detecting lung cancer susceptibility.
|
25563194 |
2015 |
|
rs25489
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among the four polymorphisms that were previously studied, only rs25489 of XRCC1 was significantly associated with lung cancer risk (dominant model, adjusted odds ratio = 0.61, 95% confidence interval = 0.46-0.83, P = 0.002).
|
25592768 |
2015 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that Arg194Trp polymorphism may be associated with increased breast cancer risk, Arg194Trp polymorphism is associated with increased glioma risk among Asians, and Arg194Trp polymorphism is associated with decreased lung cancer risk among Caucasians.
|
25064613 |
2014 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study confirms that xrcc1 rs1799782 may lower the risk of lung cancer among Caucasians.
|
25038912 |
2014 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The result involving 8,876 lung cancer patients and 11,210 controls revealed that XRCC1 Arg194Trp polymorphism was not associated with lung cancer risk [(OR=0.97, 95 %CI=0.92-1.03) for Trp vs. Arg; (OR=0.92, 95 % CI=0.85-0.98) for ArgTrp vs. ArgArg; (OR=1.07, 95 % CI=0.92-1.23) for TrpTrp vs. ArgArg; (OR=0.93, 95 % CI=0.87-1.00) for (TrpTrp + ArgTrp) vs. ArgArg; and (OR=1.08, 95 % CI=0.94-1.25) for TrpTrp vs. (ArgTrp + ArgArg)].
|
24590265 |
2014 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study aimed to explore the role of XRCC1 (Arg399Gln) and XPD (Lys751Gln) gene polymorphisms, lifestyle and environmental factors as well as their possible interactions in propensity to develop lung cancer in a population with high incidence from North East India.
|
24716924 |
2014 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Hence, we performed a meta-analysis to investigate the association between lung cancer risk and XRCC1 Arg399Gln (14,156 cases and 16,667 controls from 41 studies), Arg194Trp (7,426 cases and 9,603 controls from 23 studies), Arg280His (6,211 cases and 6,763 controls from 16 studies), -77T>C (2,487 cases and 2,576 controls from 5 studies), and XRCC3 T241M (8,560 cases and 11,557 controls from 19 studies) in different inheritance models.
|
23990873 |
2013 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To unravel its genetic underpinnings, we sought to investigate the association of three well-characterized nonsynonymous polymorphisms in XRCC1 (Arg194Trp and Arg399Gln) and XRCC3 (Thr241Met) genes with lung cancer risk in northeastern Chinese.
|
23409158 |
2013 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, there was no obvious association between XRCC1 Arg</span>194Trp polymorphism and lung cancer risk under the dominant model (OR = 1.06, 95 % CI 0.98-1.16, P = 0.146).
|
23653378 |
2013 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Hence, we performed a meta-analysis to investigate the association between lung cancer risk and XRCC1 Arg399Gln (14,156 cases and 16,667 controls from 41 studies), Arg194Trp (7,426 cases and 9,603 controls from 23 studies), Arg280His (6,211 cases and 6,763 controls from 16 studies), -77T>C (2,487 cases and 2,576 controls from 5 studies), and XRCC3 T241M (8,560 cases and 11,557 controls from 19 studies) in different inheritance models.
|
23990873 |
2013 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the present study, we investigated the polymorphisms of following selected DNA repair genes: XPC (Lys939Gln), XPD (Lys751Gln), hOGG1 (Ser326Cys) and XRCC1 (Arg399Gln), and the risks they present towards the development of lung cancer with the emphasis to gender differences within the Slovak population.
|
23673479 |
2013 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study significantly demonstrated an independent and synergistic contribution of XRCC1 Arg399Gln and XRCC3 Thr241Met polymorphisms to lung cancer susceptibility in northeastern Chinese.
|
23409158 |
2013 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The codon 399 Arg/Gln XRCC1 polymorphism is associated with lung cancer in Indians.
|
24175813 |
2013 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analysis of 18 studies with high quality also found that there was an obvious association between XRCC1 Arg</span>399Gln polymorphism and increased risk of lung cancer under three genetic models.
|
23884604 |
2013 |