Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6025
rs6025
F5
0.900 GeneticVariation BEFREE We developed a genome-wide polygenic risk score for venous thromboembolism that identifies 5% of the population at an equivalent incident venous thromboembolism risk to carriers of the established factor V Leiden p.R506Q and prothrombin G20210A mutations. 31676865

2019

dbSNP: rs6025
rs6025
F5
0.900 GeneticVariation BEFREE Our findings suggest that the risk of VTE by FHMI is not explained by rs8176719 (ABO), rs6025 (F5), rs1799963 (F2), rs2066865 (FGG), and rs2036914 (F11). 31124268

2019

dbSNP: rs6025
rs6025
F5
T 0.900 GeneticVariation GWASCAT We developed a genome-wide polygenic risk score for venous thromboembolism that identifies 5% of the population at an equivalent incident venous thromboembolism risk to carriers of the established factor V Leiden p.R506Q and prothrombin G20210A mutations. 31676865

2019

dbSNP: rs6025
rs6025
F5
T 0.900 GeneticVariation GWASCAT Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism. 31420334

2019

dbSNP: rs6025
rs6025
F5
0.900 GeneticVariation BEFREE We aimed at establishing a real-time PCR protocol for the detection of the venous thromboembolism associated mutations factor V Leiden (F5 c.1691G>A; p.R506Q) and prothrombin (F2) c.20210G>A from whole blood, without DNA extraction. 30439355

2019

dbSNP: rs6025
rs6025
F5
T 0.900 GeneticVariation GWASCAT Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor. 28373160

2017

dbSNP: rs6025
rs6025
F5
0.900 GeneticVariation BEFREE The risk of cancer-related venous thromboembolism was 16.7-fold (95% CI 9.9-28.0) higher in subjects heterozygous for rs6025 compared with non-carriers of this variant without active cancer. 27479824

2016

dbSNP: rs6025
rs6025
F5
T 0.900 GeneticVariation GWASCAT Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis. 26908601

2016

dbSNP: rs6025
rs6025
F5
0.900 GeneticVariation BEFREE While Factor V Leiden (F5 rs6025 A allele) is a known venous thromboembolism (VTE) risk factor, VTE risk among heterozygous vs. homozygous carriers is uncertain. 26970916

2016

dbSNP: rs6025
rs6025
F5
0.900 GeneticVariation BEFREE In conclusion, F5 rs6025 and F11 rs2289252 contributed to the risk of recurrent VTE and the combination is of potential clinical relevance for risk prediction. 26423325

2016

dbSNP: rs6025
rs6025
F5
T 0.900 GeneticVariation GWASCAT Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism. 25772935

2015

dbSNP: rs6025
rs6025
F5
0.900 GeneticVariation BEFREE Factor V Leiden (FVL or rs6025</span>) and prothrombin gene G20210A (PT or rs1799963) are the genetic variants currently tested for VTE risk assessment. 25341889

2014

dbSNP: rs6025
rs6025
F5
0.900 GeneticVariation BEFREE Factor V leiden G1691A/R506Q (FVL), prothrombin G20210A (FII) and methylenetetrahydrofolate reductase (MTHFR) C677T are related genetic risk factors for venous thromboembolism. 22528331

2012

dbSNP: rs6025
rs6025
F5
T 0.900 GeneticVariation GWASDB However, F5 was the main signal on 1q24.2 as only ABO SNPs remained significantly associated with VTE after adjusting for F5 rs6025. 22672568

2012

dbSNP: rs6025
rs6025
F5
0.900 GeneticVariation BEFREE However, F5 was the main signal on 1q24.2 as only ABO SNPs remained significantly associated with VTE after adjusting for F5 rs6025. 22672568

2012

dbSNP: rs6025
rs6025
F5
T 0.900 GeneticVariation GWASCAT However, F5 was the main signal on 1q24.2 as only ABO SNPs remained significantly associated with VTE after adjusting for F5 rs6025. 22672568

2012

dbSNP: rs6025
rs6025
F5
0.900 GeneticVariation GWASDB Genetics of venous thrombosis: insights from a new genome wide association study. 21980494

2011

dbSNP: rs6025
rs6025
F5
0.900 GeneticVariation BEFREE A single factor V gene G-A mutation (Arg506Gln) underlying activated protein C (APC) resistance is a common risk factor for venous thromboembolism. 9705241

1998

dbSNP: rs6025
rs6025
F5
0.900 GeneticVariation BEFREE The risk of recurrent venous thromboembolism in patients with an Arg506-->Gln mutation in the gene for factor V (factor V Leiden). 9010145

1997

dbSNP: rs2066865
rs2066865
FGG
0.860 GeneticVariation BEFREE Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism. 31582554

2019

dbSNP: rs2066865
rs2066865
FGG
0.860 GeneticVariation BEFREE Our findings suggest that the risk of VTE by FHMI is not explained by rs8176719 (ABO), rs6025 (F5), rs1799963 (F2), rs2066865 (FGG), and rs2036914 (F11). 31124268

2019

dbSNP: rs2066865
rs2066865
FGG
A 0.860 GeneticVariation GWASCAT Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease. 31676865

2019

dbSNP: rs2066865
rs2066865
FGG
0.860 GeneticVariation BEFREE A nominal significant association with VTE was found for the FGG rs2066865 minor T-allele in the dominant model (OR 1.82; P = 0.034). 29995659

2018

dbSNP: rs2066865
rs2066865
FGG
A 0.860 GeneticVariation GWASCAT Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor. 28373160

2017

dbSNP: rs2066865
rs2066865
FGG
0.860 GeneticVariation BEFREE Finally, our study demonstrated the important role of rs2289252, rs2036914, rs2066865, and rs13146272 polymorphisms in the development of VTE in the white race. 28353616

2017