|
rs7903146
|
|
|
0.050 |
GeneticVariation |
BEFREE |
For the rs7903146 polymorphism, the T allele (OR 1.19; 95% CI 1.00-1.40; P = 0.04) may be associated with the risk of LADA.
|
30456822 |
2019 |
|
rs7903146
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The rs2476601C/T, rs689A/T, and rs7903146C/T polymorphisms were found to be associated with the risk of LADA, thereby indicating that, genetically, LADA could be an admixture of both T1D and T2D.
|
30456822 |
2019 |
|
rs7903146
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Variants in the ZMIZ1 (rs12571751, p = 4.1 × 10(-5)) and TCF7L2 (rs7903146, p = 5.8 × 10(-4)) loci were strongly associated with LADA.
|
24906951 |
2014 |
|
rs7903146
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The meta-analysis demonstrates that TCF7L2 rs7903146 polymorphism is a population-independent susceptibility locus for LADA in Europeans.
|
22109281 |
2012 |
|
rs7903146
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We observed increased frequencies of the TT genotype of the rs7903146 polymorphism in the TCF7L2 gene in LADA patients compared to controls (15 vs. 6%, P = 0.03).
|
19533015 |
2010 |
|
rs7903146
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Notably, the frequency of the type 2 diabetes-associated CT/TT genotypes of rs7903146 in the TCF7L2 were increased in LADA subjects (52.8%; P = 0.03), to the same extent as in type 2 diabetic subjects (54.1%, P = 3 x 10(-7)), compared with control subjects (44.8%) and type 1 diabetic subjects (43.3%).
|
18310307 |
2008 |
|
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The aim of this meta-analysis was to determine the association of common type 1 diabetes (T1D) and type 2 diabetes (T2D) gene variants (protein tyrosine phosphatase non-receptor 22 [PTPN22] rs2476601C/T, insulin [INS] rs689A/T and transcription factor 7-like 2 [TCF7L2] rs7903146C/T) with latent autoimmune diabetes in adults (LADA).
|
30456822 |
2019 |
|
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In summary, our systematic review has demonstrated that PTPN22 rs2476601 and CTLA-4 rs231775 are potential risk factors for LADA.
|
25005490 |
2014 |
|
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The AA genotype of rs689, referring to the class I allele in the INS VNTR, as well as the CT/TT genotypes of rs2476601 in the PTPN22 gene, were increased both in type 1 diabetic (P = 3 x 10(-14) and P = 1 x 10(-10), respectively) and LADA (P = 0.001 and P = 0.002) subjects compared with control subjects.
|
18310307 |
2008 |
|
rs689
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs2476601C/T, rs689A/T, and rs7903146C/T polymorphisms were found to be associated with the risk of LADA, thereby indicating that, genetically, LADA could be an admixture of both T1D and T2D.
|
30456822 |
2019 |
|
rs689
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The AA genotype of rs689, referring to the class I allele in the INS VNTR, as well as the CT/TT genotypes of rs2476601 in the PTPN22 gene, were increased both in type 1 diabetic (P = 3 x 10(-14) and P = 1 x 10(-10), respectively) and LADA (P = 0.001 and P = 0.002) subjects compared with control subjects.
|
18310307 |
2008 |
|
rs237025
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No significant association was found between SUMO4 M55V and LADA or malnutrition-related diabetes mellitus (MRDM).
|
17373940 |
2007 |
|
rs237025
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No significant association was found between SUMO4 M55V and LADA</span>.
|
17130565 |
2006 |
|
rs3957146
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The conditional analysis in LADA versus control subjects showed significant association in the MHC class II region (rs3957146, β [SE] = 1.14 [0.06]); however, we did not observe significant independent effects of MHC class I alleles in LADA.
|
31843946 |
2020 |
|
rs9939609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated potential interactions between body mass index (BMI) and genotypes of human leukocyte antigen (HLA), TCF7L2-rs7903146, and FTO-rs9939609 in relation to the risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes.
|
31125083 |
2019 |
|
rs12571751
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants in the ZMIZ1 (rs12571751, p = 4.1 × 10(-5)) and TCF7L2 (rs7903146, p = 5.8 × 10(-4)) loci were strongly associated with LADA.
|
24906951 |
2014 |
|
rs231775
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In summary, our systematic review has demonstrated that PTPN22 rs2476601 and CTLA-4 rs231775 are potential risk factors for LADA.
|
25005490 |
2014 |
|
rs7961581
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of type 2 diabetes-associated genes, the CC/CT genotypes of rs7961581 (TSPAN8) and the obesity-linked AA/AC genotypes of rs8050136 (FTO) were associated with LADA in general, but mainly in low anti-GAD LADA patients (P = 0.004 and P = 0.004, respectively).
|
19833889 |
2010 |
|
rs8050136
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of type 2 diabetes-associated genes, the CC/CT genotypes of rs7961581 (TSPAN8) and the obesity-linked AA/AC genotypes of rs8050136 (FTO) were associated with LADA in general, but mainly in low anti-GAD LADA patients (P = 0.004 and P = 0.004, respectively).
|
19833889 |
2010 |
|
rs231806
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To evaluate the impact of CTLA-4 promoter allelic variants of the CTLA-4 gene in latent autoimmune diabetes in adults (LADA), the MH30 (rs231806), -1147 (rs16840252), and -318 (rs5742909) single nucleotide polymorphisms (SNPs) were studied in a population of Estonian origin, including 61 LADA patients and 230 controls.
|
19735686 |
2009 |
|
rs5742909
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To evaluate the impact of CTLA-4 promoter allelic variants of the CTLA-4 gene in latent autoimmune diabetes in adults (LADA), the MH30 (rs231806), -1147 (rs16840252), and -318 (rs5742909) single nucleotide polymorphisms (SNPs) were studied in a population of Estonian origin, including 61 LADA patients and 230 controls.
|
19735686 |
2009 |