Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1135401746
rs1135401746
GNB1
G 0.700 GeneticVariation CLINVAR

dbSNP: rs121909646
rs121909646
FLT3
0.700 GeneticVariation UNIPROT

dbSNP: rs121913232
rs121913232
FLT3
0.700 GeneticVariation UNIPROT

dbSNP: rs121913487
rs121913487
FLT3
0.700 GeneticVariation UNIPROT

dbSNP: rs121913488
rs121913488
FLT3
0.700 GeneticVariation UNIPROT

dbSNP: rs1478147351
rs1478147351
SETD2
0.700 GeneticVariation UNIPROT

dbSNP: rs186148199
rs186148199
SETD2
0.700 GeneticVariation UNIPROT

dbSNP: rs188887061
rs188887061
SETD2
0.700 GeneticVariation UNIPROT

dbSNP: rs398123063
rs398123063
PAX5 ; LOC105376032
0.700 GeneticVariation UNIPROT

dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE A common C to T transition (C677T) in the MTHFR gene is reported to reduce the risk for colorectal cancer and acute lymphocytic leukemia in homozygotes (TTs). 11408344

2001
dbSNP: rs1800562
rs1800562
HFE ; LOC108783645
0.010 GeneticVariation BEFREE Contrary to some expectations, however, the frequency of the C282Y allele in acute lymphoblastic leukemia turned out to be normal (7.0%, n=43). 11836162

2002
dbSNP: rs1045642
rs1045642
ABCB1
0.030 GeneticVariation BEFREE Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemia. 12851703

2003
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE In order to test this association we studied the presence of the C677T and A1298C mutant alleles in 174 patients with acute lymphoblastic leukemia and in 110 controls from central Italy. 15003888

2004
dbSNP: rs397507444
rs397507444
MTHFR
0.070 GeneticVariation BEFREE In order to test this association we studied the presence of the C677T and A1298C mutant alleles in 174 patients with acute lymphoblastic leukemia and in 110 controls from central Italy. 15003888

2004
dbSNP: rs61754966
rs61754966
NBN
0.010 GeneticVariation BEFREE Four children with acute lymphoblastic leukemia have been reported to be heterozygous for a germline and/or somatic missense mutation in NBS1, leading to the I171V substitution. 15338273

2004
dbSNP: rs121913459
rs121913459
ABL1
0.020 GeneticVariation BEFREE MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation. 16990603

2007
dbSNP: rs13181
rs13181
ERCC2 ; KLC3
0.010 GeneticVariation BEFREE In this analysis, small associations of the XPD Lys 751 Gln polymorphism with cancer risk for esophageal cancer [for Lys/Gln versus Lys/Lys: odds ratio (OR), 1.34; 95% confidence interval (95% CI), 1.10-1.64; for Gln/Gln versus Lys/Lys: OR, 1.61; 95% CI, 1.16-2.25] and acute lymphoblastic leukemia (for Gln/Gln versus Lys/Lys: OR, 1.83; 95% CI, 1.21-2.75) are revealed. 18349268

2008
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE We investigated preliminarily whether methylenetetrahydrofolate reductase (MTHFR) 677C/T or reduced folate carrier 1 (RFC1) 80G/A polymorphisms were associated with toxicities during maintenance chemotherapy with mercaptopurine (6MP) and methotrexate (MTX) in children with acute lymphoblastic leukemia or lymphoblastic lymphoma. 18458567

2008
dbSNP: rs368087026
rs368087026
SLC19A1
0.010 GeneticVariation BEFREE We investigated preliminarily whether methylenetetrahydrofolate reductase (MTHFR) 677C/T or reduced folate carrier 1 (RFC1) 80G/A polymorphisms were associated with toxicities during maintenance chemotherapy with mercaptopurine (6MP) and methotrexate (MTX) in children with acute lymphoblastic leukemia or lymphoblastic lymphoma. 18458567

2008
dbSNP: rs775144154
rs775144154
SLC19A1
0.010 GeneticVariation BEFREE We investigated preliminarily whether methylenetetrahydrofolate reductase (MTHFR) 677C/T or reduced folate carrier 1 (RFC1) 80G/A polymorphisms were associated with toxicities during maintenance chemotherapy with mercaptopurine (6MP) and methotrexate (MTX) in children with acute lymphoblastic leukemia or lymphoblastic lymphoma. 18458567

2008
dbSNP: rs121913448
rs121913448
ABL1
0.010 GeneticVariation BEFREE The Ph (+) ALL patient had a Glu255Lys mutation in exon 5 and a Thr315Ile mutation in exon 7. 18603297

2008
dbSNP: rs387906517
rs387906517
ABL1
0.010 GeneticVariation BEFREE The Ph (+) ALL patient had a Glu255Lys mutation in exon 5 and a Thr315Ile mutation in exon 7. 18603297

2008
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE Certain common polymorphisms within the MTHFR gene (C677T, A1298C) result in reduced enzymatic activity and have been associated with reduced risk for a variety of cancers such as acute lymphocytic leukemia, lung and colorectal cancer. 18804702

2008
dbSNP: rs397507444
rs397507444
MTHFR
0.070 GeneticVariation BEFREE Certain common polymorphisms within the MTHFR gene (C677T, A1298C) result in reduced enzymatic activity and have been associated with reduced risk for a variety of cancers such as acute lymphocytic leukemia, lung and colorectal cancer. 18804702

2008
dbSNP: rs1569175
rs1569175 		T 0.700 GeneticVariation GWASCAT Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. 19176441

2009