|
rs9275319
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Of the 12 SNPs reported in HBV-related HCC GWASs, five SNPs (rs7574865 in STAT4, rs9267673 near C2, rs2647073 and rs3997872 near HLA-DRB1 and rs9275319 near HLA-DQ), were found to be significantly associated with the risk of HBV-related LC (rs7574865: P = 1.79 × 10(-2), OR = 1.17, 95% CI = 1.03-1.34; rs9267673: P = 4.91 × 10(-4), OR = 1.37, 95% CI = 1.15-1.63; rs2647073: P = 3.53 × 10(-5), OR = 1.63, 95% CI = 1.29-2.06; rs3997872: P = 4.22 × 10(-4), OR = 1.86, 95% CI = 1.32-2.62; rs9275319: P = 1.30 × 10(-2), OR = 1.32, 95% CI = 1.06-1.64).
|
26538132 |
2015 |
|
rs9275319
|
|
A |
0.850 |
GeneticVariation |
GWASDB |
The joint analyses showed that HCC risk was significantly associated with two independent loci: rs7574865 at STAT4, P(meta) = 2.48 × 10(-10), odds ratio (OR) = 1.21; and rs9275319 at HLA-DQ, P(meta) = 2.72 × 10(-17), OR = 1.49.
|
23242368 |
2013 |
|
rs9275319
|
|
|
0.850 |
GeneticVariation |
BEFREE |
A recent genome-wide association study (GWAS) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) identified two loci (rs7574865 in STAT4 and rs9275319 in HLA-DQ) in a Chinese population.
|
25913043 |
2015 |
|
rs9275319
|
|
A |
0.850 |
GeneticVariation |
GWASCAT |
The joint analyses showed that HCC risk was significantly associated with two independent loci: rs7574865 at STAT4, P(meta) = 2.48 × 10(-10), odds ratio (OR) = 1.21; and rs9275319 at HLA-DQ, P(meta) = 2.72 × 10(-17), OR = 1.49.
|
23242368 |
2013 |
|
rs9275319
|
|
|
0.850 |
GeneticVariation |
BEFREE |
In addition, no significant association was observed between <i>HLA-DQ rs9275319-G</i> polymorphism and HBV-related HCC.
|
29416599 |
2018 |
|
rs9275319
|
|
|
0.850 |
GeneticVariation |
BEFREE |
The joint analyses showed that HCC risk was significantly associated with two independent loci: rs7574865 at STAT4, P(meta) = 2.48 × 10(-10), odds ratio (OR) = 1.21; and rs9275319 at HLA-DQ, P(meta) = 2.72 × 10(-17), OR = 1.49.
|
23242368 |
2013 |
|
rs9275319
|
|
|
0.850 |
GeneticVariation |
BEFREE |
We performed a multi-centre study of 1,507 HBV-related HCC cases and 1,560 HBV persistent carriers as controls to evaluate the effects of HBV genotype, mutations, GWAS-identified HLA-DQ/DR SNPs (rs9272105 and rs9275319) and their interactions on HCC risk.
|
26568165 |
2015 |
|
rs9275572
|
|
|
0.840 |
GeneticVariation |
BEFREE |
We found that rs2856718 and rs9275572 in HLA-DQ significantly decreased HBV-related HCC in total population, especially in Chinese, but not in Saudi Arabian.
|
28761441 |
2017 |
|
rs9275572
|
|
A |
0.840 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.
|
21499248 |
2011 |
|
rs9275572
|
|
A |
0.840 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.
|
21499248 |
2011 |
|
rs9275572
|
|
|
0.840 |
GeneticVariation |
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
rs9275572
|
|
|
0.840 |
GeneticVariation |
BEFREE |
The AG/GG genotype of rs9275572 and HLA-DQB1 Block2 CCCCC haplotype may have protective effects in HBV-related HCC patients receiving hepatic resection.
|
27288300 |
2016 |
|
rs9275572
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Our study suggested that HLA-DQ loci (rs9</span>275572) were associated with HBV-related HCC as a protective factor in Han Chinese.
|
27209411 |
2016 |
|
rs9275572
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Two recent genome-wide studies showed that the single-nucleotide polymorphisms in the HLA-DQ region (rs2856718 and rs9275572) were associated with chronic hepatitis B virus infection and chronic hepatitis C virus-associated hepatocellular carcinoma in Japanese patients.
|
24750255 |
2014 |
|
rs2856718
|
|
|
0.750 |
GeneticVariation |
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
rs2856718
|
|
|
0.750 |
GeneticVariation |
BEFREE |
We found that rs2856718 and rs9275572 in HLA-DQ significantly decreased HBV-related HCC in total population, especially in Chinese, but not in Saudi Arabian.
|
28761441 |
2017 |
|
rs2856718
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Two recent genome-wide studies showed that the single-nucleotide polymorphisms in the HLA-DQ region (rs2856718 and rs9275572) were associated with chronic hepatitis B virus infection and chronic hepatitis C virus-associated hepatocellular carcinoma in Japanese patients.
|
24750255 |
2014 |
|
rs2856718
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Logistic regression analyses showed that HLA-DQ rs2856718 significantly decreased host HCC risk, whereas three SNPs were associated with HBV clearance (HLA-DP rs9277535 as well as HLA-DQ rs7453920 and rs2856718).
|
22105689 |
2012 |
|
rs2856718
|
|
|
0.750 |
GeneticVariation |
BEFREE |
This study revealed an association between rs2856718 and HCC development and an association between rs7453920 and HBsAg levels.
|
27580643 |
2017 |
|
rs2856718
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Several recent genome-wide studies showed that the genetic polymorphisms in the HLA-DQ region (rs9275572 and rs2856718) were related to chronic hepatitis B virus (HBV) infection and chronic hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC).
|
27209411 |
2016 |
|
rs10484561
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
rs17007417
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers.
|
29385134 |
2018 |
|
rs2647012
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
rs2856683
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
rs2856723
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Human leukocyte antigen variants and risk of hepatocellular carcinoma modified by hepatitis C virus genotypes: A genome-wide association study.
|
28921602 |
2018 |