|
rs7574865
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our data demonstrated positive association of rs7574865 with HCC risk when compared to healthy controls under an additive model (GG versus TT: odds ratio (OR) =2.07, 95% confidence interval (CI)=1.06-4.03, P=0.033).
|
26745093 |
2015 |
|
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis showed a significant association between KIF1B rs17401966 polymorphism and HCC.
|
24952890 |
2014 |
|
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A moderate increase in differentiation was noted for rs2596542 (F st = 0.106) and rs17401966 (F st = 0.116), single nucleotide polymorphisms (SNPs) associated with an increased risk of HCC in patients with chronic HCV and HBV, respectively.
|
24357186 |
2014 |
|
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The SNP rs17401966 was genotyped using the TaqMan allelic discrimination assay in 414 intermediate or advanced hepatocellular carcinoma patients.
|
25153661 |
2014 |
|
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Homozygous mutation of rs1081432 conferred a 2.68-fold risk of HCC (95% CI 1.35-5.34); however heterozygosity was not statistically significant. rs17401966 heterozygosity or homozygosity was not significantly associated with a increased risk of HCC.
|
25412941 |
2014 |
|
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A moderate increase in differentiation was noted for rs2596542 (F st = 0.106) and rs17401966 (F st = 0.116), single nucleotide polymorphisms (SNPs) associated with an increased risk of HCC in patients with chronic HCV and HBV, respectively.
|
24357186 |
2014 |
|
rs7574865
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Moreover, current data failed to acquire positive connection of rs7574865 with HCC development (experiment, OR = 0.86, 95%CI = 0.62-1.19; meta-analysis, OR = 0.87, 95%CI = 0.74-1.03), which may be due to the small sample size.
|
25365208 |
2014 |
|
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Binary logistic regression showed that rs17401966 was not statistically associated with the risk of HCC development in Thai chronic HBV patients (p-value=0.998, OR=1.00 and 95% CI=0.68-1.48).
|
23803045 |
2013 |
|
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These findings demonstrate that the presence of the G allele at rs17401966 of the KIF1B gene may decrease the risk for HCC and suggest that KIF1B may play a critical role in the development of HCC.
|
23634229 |
2013 |
|
rs17401966
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To our surprise, the minor allele A of rs2596542 in proximity of MICA appeared to have a protective impact on HCC development in Caucasians, which represents an inverse association as compared to the one observed in the Japanese population.
|
23665287 |
2013 |
|
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Moreover, SNP rs2596538 showed stronger association with HCV-induced HCC (P = 1.82 × 10(-5) and OR = 1.34) than the previously identified SNP rs2596542.
|
23593449 |
2013 |
|
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A recent genome-wide association study has identified a single nucleotide polymorphism (SNP) of MICA, rs2596542 to be significantly associated with hepatitis C-induced hepatocellular carcinoma (HCC) in a Japanese population.
|
23994040 |
2013 |
|
rs2596542
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
rs7574865
|
|
G |
0.900 |
GeneticVariation |
GWASCAT |
The risk allele G at rs7574865 was significantly associated with lower mRNA levels of STAT4 in both the HCC tissues and nontumor tissues of 155 individuals with HBV-related HCC (P(trend) = 0.0008 and 0.0002, respectively).
|
23242368 |
2013 |
|
rs7574865
|
|
G |
0.900 |
GeneticVariation |
GWASDB |
The risk allele G at rs7574865 was significantly associated with lower mRNA levels of STAT4 in both the HCC tissues and nontumor tissues of 155 individuals with HBV-related HCC (P(trend) = 0.0008 and 0.0002, respectively).
|
23242368 |
2013 |
|
rs7574865
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The STAT4 variant (rs7574865) was marginally associated with HCC susceptibility in CHB carriers in allelic and recessive genetic models (OR=0.84, 95%CI=0.7-0.99, P=0.048 and OR=0.7, 95%CI=0.5-0.99, P=0.047).
|
23748017 |
2013 |
|
rs7574865
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The risk allele G at rs7574865 was significantly associated with lower mRNA levels of STAT4 in both the HCC tissues and nontumor tissues of 155 individuals with HBV-related HCC (P(trend) = 0.0008 and 0.0002, respectively).
|
23242368 |
2013 |
|
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
None of the replication cohorts showed associations between rs17401966 and HBV-derived HCC.
|
22712471 |
2012 |
|
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The genetic association analysis revealed a nominal association with an SNP rs2596542; a G allele was considered to increase the risk of HBV-induced HCC (P = 0.029 with odds ratio of 1.19).
|
23024757 |
2012 |
|
rs2596542
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.
|
21499248 |
2011 |
|
rs2596542
|
|
A |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.
|
21499248 |
2011 |
|
rs17401966
|
|
A |
0.900 |
GeneticVariation |
GWASDB |
We identified one intronic SNP (rs17401966) in KIF1B on chromosome 1p36.22 that was highly associated with HBV-related HCC and confirmed this association in five additional independent samples, consisting of 1,962 individuals with HCC, 1,430 control subjects and 159 family trios.
|
20676096 |
2010 |
|
rs17401966
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
We identified one intronic SNP (rs17401966) in KIF1B on chromosome 1p36.22 that was highly associated with HBV-related HCC and confirmed this association in five additional independent samples, consisting of 1,962 individuals with HCC, 1,430 control subjects and 159 family trios.
|
20676096 |
2010 |
|
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We identified one intronic SNP (rs17401966) in KIF1B on chromosome 1p36.22 that was highly associated with HBV-related HCC and confirmed this association in five additional independent samples, consisting of 1,962 individuals with HCC, 1,430 control subjects and 159 family trios.
|
20676096 |
2010 |