Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2596542
rs2596542
0.880 GeneticVariation BEFREE Genetic variants of MHC class I polypeptide-related chain A (MICA) at rs2596542 have been associated with hepatocellular carcinoma. 28427234

2018

dbSNP: rs2596542
rs2596542
0.880 GeneticVariation BEFREE For cirrhotic non-SVR patients, high sMICA levels (HR/CI: 5·93/1·86-26.38·61, P=0·002) and the MICA rs2596542 A allele (HR/CI: 4·37/1·52-12·07, P=0·002) were independently associated with HCC development. 27998720

2017

dbSNP: rs2596542
rs2596542
0.880 GeneticVariation BEFREE In a Northern Italian discovery cohort (n = 477), neither DEPDC5 rs1012068 nor MICA rs2596542 were associated with HCC (n = 150). 26517016

2016

dbSNP: rs2596542
rs2596542
0.880 GeneticVariation BEFREE CONCLUSIONS IFN-γ rs2069727 and MICA rs2596542 polymorphisms may be related to the incidence of HCC. 26893439

2016

dbSNP: rs2596542
rs2596542
0.880 GeneticVariation BEFREE Therefore, this study aims to investigate whether the SNP rs2596542 plays any role in hepatitis B virus (HBV) sero-clearance or in the development of complications associated with chronic HBV such as cirrhosis and/or HCC. 23994040

2014

dbSNP: rs2596542
rs2596542
0.880 GeneticVariation BEFREE To our surprise, the minor allele A of rs2596542 in proximity of MICA appeared to have a protective impact on HCC development in Caucasians, which represents an inverse association as compared to the one observed in the Japanese population. 23665287

2014

dbSNP: rs2596542
rs2596542
0.880 GeneticVariation BEFREE The genetic association analysis revealed a nominal association with an SNP rs2596542; a G allele was considered to increase the risk of HBV-induced HCC (P = 0.029 with odds ratio of 1.19). 23024757

2013

dbSNP: rs2596542
rs2596542
0.880 GeneticVariation BEFREE Moreover, SNP rs2596538 showed stronger association with HCV-induced HCC (P = 1.82 × 10(-5) and OR = 1.34) than the previously identified SNP rs2596542. 23593449

2013

dbSNP: rs2596542
rs2596542
0.880 GeneticVariation GWASDB Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. 23242368

2013

dbSNP: rs2596542
rs2596542
0.880 GeneticVariation GWASDB Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. 21499248

2011

dbSNP: rs2596542
rs2596542
0.880 GeneticVariation GWASCAT Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. 21499248

2011

dbSNP: rs7574865
rs7574865
0.850 GeneticVariation BEFREE A recent genome-wide association study (GWAS) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) identified two loci (rs7574865 in STAT4 and rs9275319 in HLA-DQ) in a Chinese population. 25913043

2016

dbSNP: rs7574865
rs7574865
0.850 GeneticVariation BEFREE Of the 12 SNPs reported in HBV-related HCC GWASs, five SNPs (rs7574865 in STAT4, rs9267673 near C2, rs2647073 and rs3997872 near HLA-DRB1 and rs9275319 near HLA-DQ), were found to be significantly associated with the risk of HBV-related LC (rs7574865: P = 1.79 × 10(-2), OR = 1.17, 95% CI = 1.03-1.34; rs9267673: P = 4.91 × 10(-4), OR = 1.37, 95% CI = 1.15-1.63; rs2647073: P = 3.53 × 10(-5), OR = 1.63, 95% CI = 1.29-2.06; rs3997872: P = 4.22 × 10(-4), OR = 1.86, 95% CI = 1.32-2.62; rs9275319: P = 1.30 × 10(-2), OR = 1.32, 95% CI = 1.06-1.64). 26538132

2016

dbSNP: rs7574865
rs7574865
0.850 GeneticVariation BEFREE We observed that the STAT4 (2q32.2-q32.3) at rs7574865 (P=1.17×10(-3), OR=0.79) and EFCAB11 (14q32.11) at rs8013403 (P=1.54×10(-3), OR=0.80) were significantly associated with HCC in this study. 25665738

2015

dbSNP: rs7574865
rs7574865
0.850 GeneticVariation BEFREE Moreover, current data failed to acquire positive connection of rs7574865 with HCC development (experiment, OR = 0.86, 95%CI = 0.62-1.19; meta-analysis, OR = 0.87, 95%CI = 0.74-1.03), which may be due to the small sample size. 25365208

2015

dbSNP: rs7574865
rs7574865
0.850 GeneticVariation BEFREE The STAT4 variant (rs7574865) was marginally associated with HCC susceptibility in CHB carriers in allelic and recessive genetic models (OR=0.84, 95%CI=0.7-0.99, P=0.048 and OR=0.7, 95%CI=0.5-0.99, P=0.047). 23748017

2014

dbSNP: rs7574865
rs7574865
0.850 GeneticVariation GWASDB Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. 23242368

2013

dbSNP: rs7574865
rs7574865
0.850 GeneticVariation GWASCAT Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. 23242368

2013

dbSNP: rs17401966
rs17401966
0.840 GeneticVariation BEFREE The SNP rs17401966 was genotyped using the TaqMan allelic discrimination assay in 414 intermediate or advanced hepatocellular carcinoma patients. 25153661

2015

dbSNP: rs17401966
rs17401966
0.840 GeneticVariation BEFREE Association between KIF1B rs17401966 polymorphism and hepatocellular carcinoma risk: a meta-analysis involving 17,210 subjects. 24952890

2014

dbSNP: rs17401966
rs17401966
0.840 GeneticVariation BEFREE These findings demonstrate that the presence of the G allele at rs17401966 of the KIF1B gene may decrease the risk for HCC and suggest that KIF1B may play a critical role in the development of HCC. 23634229

2013

dbSNP: rs17401966
rs17401966
0.840 GeneticVariation GWASDB Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. 23242368

2013

dbSNP: rs17401966
rs17401966
0.840 GeneticVariation GWASDB Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. 20676096

2010

dbSNP: rs17401966
rs17401966
0.840 GeneticVariation GWASCAT Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. 20676096

2010

dbSNP: rs17401966
rs17401966
0.840 GeneticVariation BEFREE We identified one intronic SNP (rs17401966) in KIF1B on chromosome 1p36.22 that was highly associated with HBV-related HCC and confirmed this association in five additional independent samples, consisting of 1,962 individuals with HCC, 1,430 control subjects and 159 family trios. 20676096

2010