rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
More well-designed studies with larger sample size and various ethnic groups and risk factors are needed to establish that KIF1B rs17401966 polymorphism is significantly associated with risk of HCC.
|
30947687 |
2019 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, genotype frequencies of rs2596542A/G SNP were statistically different between HCV-induced HCC patients and controls (p = 0.048), and also between HCC and HCV-induced cirrhosis patients (p = 0.039).
|
31471884 |
2019 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The findings of this meta-analysis suggest that the rs2596542 variant in the MICA promoter region may affect MICA and soluble MICA (sMICA) protein expression, thereby influencing physiological vulnerability to HCC cells and the development of HCC.
|
31419949 |
2019 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma (HCC) in Japanese patients.
|
30723271 |
2019 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Nevertheless, we also detected significant associations between rs259</span>6542G>A and HCV-induced HCC</span>.
|
30967497 |
2019 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A meta-analysis was performed to examine the association between MICA rs2596542 polymorphism and susceptibility to HCC.
|
30882647 |
2019 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Taken together our study suggest that MICA rs2596542 SNP impacts HCV-induced HCC susceptibility suggesting that genetic variants in MICA are of clinical relevance to hepatocarcinogenesis by impacting host immune response in chronic HCV infection.
|
31471884 |
2019 |
rs7574865
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The present study also indicates that <i>STAT4</i> rs7574865 polymorphism increased the risk of chronic HBV infection and HCC.
|
31160486 |
2019 |
rs7574865
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In contrast, STAT4-rs7574865 was associated with HCC only in HBV infected patients (p = 0.03) and the other tested SNP were not linked with HCC risk.
|
30289982 |
2019 |
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis suggested that KIF1B (rs17401966) polymorphism could decrease HCC risk in Chinese and in overall population, but not in non-Chinese.
|
29881295 |
2018 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We enrolled 787 consecutive patients with chronic HCV infection, which included 174 cases of HCC, and 325 healthy subjects to clarify the involvement of HLA-Bw and C, KIRs, and major histocompatibility complex class I chain-related gene A (MICA) gene polymorphisms (rs2596542 and rs1051792) in chronic HCV infection and HCV-related HCC.
|
29731972 |
2018 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These results demonstrate that MICA rs2596542G/G, and particularly the rs2596538C/C polymorphism, are associated with the risk of developing HCV-related HCC in a Sicilian population sample.
|
29584564 |
2018 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Finally, sMICA levels significantly increased during HCV-related liver disease progression, while a significant relationship between both rs2596542 and rs2596538 genotypes and sMICA plasma levels was identified in patients with LC and HCC.
|
29584564 |
2018 |
rs7574865
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We identified that <i>STAT4</i>-rs7574865 polymorphism was significantly associated with an increased risk of HCC in allelic contrast, dominant, homozygote and recessive models.
|
30310516 |
2018 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recently, the MICA rs2596542 and DEPDC5 rs1012068 variants in Japanese individuals as well as the HCP5 rs2244546 and PNPLA3 rs738409 variants in European individuals have been found associated with hepatocellular carcinoma (HCC).
|
28928439 |
2017 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For cirrhotic non-SVR patients, high sMICA levels (HR/CI: 5·93/1·86–26·38, P = 0·002) [corrected] and the MICA rs2596542 A allele (HR/CI: 4·37/1·52–12·07, P = 0·002) were independently associated with HCC development.
|
27998720 |
2017 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Studying SNP rs2596542C/T association with HCC and LC susceptibility revealed that statistical significant differences (<i>P</i> = 0.013, <i>P</i> = 0.027) were only observed between SNP rs2596542C/T and each of HCC and LC, respectively, versus healthy controls, indicating that the rs2596542C/T genetic variation is not a significant contributor to HCC development in LC patients.
|
28417047 |
2017 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Genetic variants of MHC class I polypeptide-related chain A (MICA) at rs2596542 have been associated with hepatocellular carcinoma.
|
28427234 |
2017 |
rs7574865
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A significantly increased risk of HCC associated with the rs7574865</span> G was found.
|
27126090 |
2017 |
rs17401966
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The gene-environment interaction between the KIF1B rs17401966 variant and alcohol consumption may contribute to the development of HCC in Chinese individuals.
|
27122668 |
2016 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
CONCLUSIONS IFN-γ rs2069727 and MICA rs2596542 polymorphisms may be related to the incidence of HCC.
|
26893439 |
2016 |
rs2596542
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In a Northern Italian discovery cohort (n = 477), neither DEPDC5 rs1012068 nor MICA rs2596542 were associated with HCC (n = 150).
|
26517016 |
2016 |
rs7574865
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We observed that the STAT4 (2q32.2-q32.3) at rs7574865 (P=1.17×10(-3), OR=0.79) and EFCAB11 (14q32.11) at rs8013403 (P=1.54×10(-3), OR=0.80) were significantly associated with HCC in this study.
|
25665738 |
2015 |
rs7574865
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A recent genome-wide association study (GWAS) for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) identified two loci (rs7574865 in STAT4 and rs9275319 in HLA-DQ) in a Chinese population.
|
25913043 |
2015 |
rs7574865
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Of the 12 SNPs reported in HBV-related HCC GWASs, five SNPs (rs7574865 in STAT4, rs9267673 near C2, rs2647073 and rs3997872 near HLA-DRB1 and rs9275319 near HLA-DQ), were found to be significantly associated with the risk of HBV-related LC (rs7574865: P = 1.79 × 10(-2), OR = 1.17, 95% CI = 1.03-1.34; rs9267673: P = 4.91 × 10(-4), OR = 1.37, 95% CI = 1.15-1.63; rs2647073: P = 3.53 × 10(-5), OR = 1.63, 95% CI = 1.29-2.06; rs3997872: P = 4.22 × 10(-4), OR = 1.86, 95% CI = 1.32-2.62; rs9275319: P = 1.30 × 10(-2), OR = 1.32, 95% CI = 1.06-1.64).
|
26538132 |
2015 |