Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs138213197
rs138213197
0.060 GeneticVariation BEFREE A rare recurrent missense variant in HOXB13 (rs138213197/G84E) was recently reported to be associated with hereditary prostate cancer. 25595936

2015

dbSNP: rs138213197
rs138213197
0.060 GeneticVariation BEFREE Men with the HOXB13 G84E variant had a 4.51-fold higher relative risk of PCa compared with non-carriers (95 % CI 3.28-6.20). 24026887

2014

dbSNP: rs138213197
rs138213197
0.060 GeneticVariation BEFREE A rare but recurrent missense mutation (G84E, rs138213197) in the gene homeobox B13 (HOXB13) was recently reported to be associated with hereditary prostate cancer. 22841674

2014

dbSNP: rs138213197
rs138213197
0.060 GeneticVariation BEFREE Recent genetic epidemiologic studies identified a germline mutation in the homeobox transcription factor, HOXB13 G84E, which is associated with markedly increased risk for prostate cancer, particularly early-onset hereditary prostate cancer. 24722062

2014

dbSNP: rs138213197
rs138213197
0.060 GeneticVariation BEFREE The novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer. 22236224

2012

dbSNP: rs138213197
rs138213197
0.060 GeneticVariation BEFREE We evaluated the G84E germline mutation (rs138213197) of HOXB13 in a case-control study of familial prostate cancer at Vanderbilt University (Nashville, TN) to independently evaluate the association of the mutation with familial prostate cancer. 22714738

2012

dbSNP: rs4792311
rs4792311
0.030 GeneticVariation BEFREE In the stratified analyses for Ser217Leu polymorphism, there was significantly increased prostate cancer risk in Asian and Caucasian populations, and studies using sporadic and familial prostate cancer cases. 20231859

2010

dbSNP: rs486907
rs486907
0.030 GeneticVariation BEFREE Forty percent (8/20) of familial prostate cancer patients homozygous for a mutation in RNase L (R462Q) were positive for XMRV, while the virus was rarely (1/66) detected in familial prostate cancer patients heterozygous for R462Q or carrying the wild type allele. 18823818

2008

dbSNP: rs486907
rs486907
0.030 GeneticVariation BEFREE The RNASEL (encoding ribonuclease L) gene Glu265X mutation has been implicated in familial prostate cancer, and an association between the RNASEL Arg462Gln variant and sporadic and familial prostate cancer, has also been suggested. 15981205

2005

dbSNP: rs486907
rs486907
0.030 GeneticVariation BEFREE Cosegregation between the truncating mutation E265X and disease in a hereditary prostate cancer (HPC) family and association between prostate cancer risk and the common missense variant R462Q has been reported. 15534086

2004

dbSNP: rs4792311
rs4792311
0.030 GeneticVariation BEFREE Although no difference in allele frequency at Ser217Leu between patients with PCa and controls has been reported in a Western population, this polymorphism is a potential indicator of PCa risk in Japanese men and it should be examined in other ethnic groups. 12949798

2003

dbSNP: rs4792311
rs4792311
0.030 GeneticVariation BEFREE A truncating mutation was found in one hereditary prostate cancer (HPC) family, whereas two missense variants, Ser217Leu and Ala541Thr, were reported to be associated with increased PRCA risk in the general population. 11507049

2001

dbSNP: rs3803185
rs3803185
0.020 GeneticVariation BEFREE This study provides strong confirmation of the important role of ARLTS1 Cys148Arg variant as a contributor in PCa predisposition and a potential marker for aggressive disease outcome. 22028916

2011

dbSNP: rs3803185
rs3803185
0.020 GeneticVariation BEFREE Our results suggest that Trp149Stop is not a predisposition allele in breast, prostate, or colorectal cancer in the Finnish population, and, while the Gly65Val variant may increase familial prostate cancer risk and the Cys148Arg change may affect both breast and prostate cancer risk, the evidence is not strong in these data. 18337727

2008

dbSNP: rs627928
rs627928
0.020 GeneticVariation BEFREE Genotyping of HPC2/ELAC2 variants (S217L, A541T), along with RNASEL variants (R462Q and E541D) was completed in 155 African American sporadic and 88 familial prostate cancer cases, and 296 healthy male controls. 18767027

2008

dbSNP: rs74315364
rs74315364
0.020 GeneticVariation BEFREE The RNASEL (encoding ribonuclease L) gene Glu265X mutation has been implicated in familial prostate cancer, and an association between the RNASEL Arg462Gln variant and sporadic and familial prostate cancer, has also been suggested. 15981205

2005

dbSNP: rs74315364
rs74315364
0.020 GeneticVariation BEFREE Cosegregation between the truncating mutation E265X and disease in a hereditary prostate cancer (HPC) family and association between prostate cancer risk and the common missense variant R462Q has been reported. 15534086

2004

dbSNP: rs627928
rs627928
0.020 GeneticVariation BEFREE To further test for potential associations between genes and increased risk for disease, the three missense polymorphisms (Ile97Leu, Arg462Gln, and Glu541Asp) were genotyped in 438 patients with familial PC and in 510 population-based control subjects. 12022038

2002

dbSNP: rs10486567
rs10486567
0.010 GeneticVariation BEFREE Assessing interactions of two loci (rs4242382 and rs10486567) in familial prostate cancer: statistical evaluation of epistasis. 24586834

2014

dbSNP: rs4242382
rs4242382
0.010 GeneticVariation BEFREE Assessing interactions of two loci (rs4242382 and rs10486567) in familial prostate cancer: statistical evaluation of epistasis. 24586834

2014

dbSNP: rs2645429
rs2645429
0.010 GeneticVariation BEFREE The A allele of rs2645429 was significantly associated with prostate cancer risk in a Japanese familial prostate cancer population. 22546838

2012

dbSNP: rs1447295
rs1447295
0.010 GeneticVariation BEFREE Association of SNP rs1447295 and microsatellite marker DG8S737 with familial prostate cancer and high grade disease. 20639049

2010

dbSNP: rs1042028
rs1042028
0.010 GeneticVariation BEFREE The present study was conducted to confirm the association of a G638A polymorphism, Arg213His, in SULT1A1 with familial prostate cancer risk in a Japanese population. 18368507

2008

dbSNP: rs117251022
rs117251022
0.010 GeneticVariation BEFREE Our results suggest that Trp149Stop is not a predisposition allele in breast, prostate, or colorectal cancer in the Finnish population, and, while the Gly65Val variant may increase familial prostate cancer risk and the Cys148Arg change may affect both breast and prostate cancer risk, the evidence is not strong in these data. 18337727

2008

dbSNP: rs1374051619
rs1374051619
0.010 GeneticVariation BEFREE Genotyping of HPC2/ELAC2 variants (S217L, A541T), along with RNASEL variants (R462Q and E541D) was completed in 155 African American sporadic and 88 familial prostate cancer cases, and 296 healthy male controls. 18767027

2008