Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4986790
rs4986790
0.020 GeneticVariation BEFREE Two specific polymorphisms of toll-like receptor 4 (TLR4; Asp299Gly and Thr399Ile) have recently been identified either as candidate protector genes against DM2 and associated neuropathy or risk alleles for the manifestation of diabetic retinopathy. 21628510

2011

dbSNP: rs4986790
rs4986790
0.020 GeneticVariation BEFREE In conclusion, our results suggest an association between the Asp299Gly polymorphism of the TLR4 gene and early onset of DR in the DM2 patients. 19135114

2009

dbSNP: rs3025039
rs3025039
0.010 GeneticVariation BEFREE We conclude that the VEGF+936 C/T (rs3025039) gene polymorphisms are related to peripheral neuropathy in Mexican DM2 patients, with the heterozygous genotype potentially conferring a protective effect. 31499478

2019

dbSNP: rs13266634
rs13266634
0.010 GeneticVariation BEFREE Several investigations in animal models demonstrate the protective role of MT in DM2 and its cardiovascular or renal complications, while a copious literature shows that a common polymorphism (R325W) in ZnT8, which affects the protein's zinc transport activity, is associated with increased DM2 risk. 28845600

2017

dbSNP: rs1303471186
rs1303471186
0.010 GeneticVariation BEFREE Genetic testing was positive for DM2 (2650 CCTG repeat) and for a variant c.215C>T (p.Pro72Leu) in the SCN4A gene. 25660391

2015

dbSNP: rs374057152
rs374057152
0.010 GeneticVariation BEFREE Single nucleotide polymorphism (SNP) C936T of the vascular endothelial growth factor (VEGF) gene and the SNP C242T of the p22phox (CYBA) gene have been investigated in relation to DM2 and its complications. 26130419

2015

dbSNP: rs699
rs699
AGT
0.010 GeneticVariation BEFREE Our results suggest that there is an association between the AGT rs699 polymorphism and DM2 in a Brazilian sample. 26782563

2015

dbSNP: rs1137100
rs1137100
0.010 GeneticVariation BEFREE In addition, the AA genotype of the K109R LEPR polymorphism was significantly less frequent in centenarians than in the Y, MI, and DM2 groups (p = 0.026, p = 0.013, and p = 0.001, respectively). 24549597

2014

dbSNP: rs622342
rs622342
0.010 GeneticVariation BEFREE In cancer patients without DM2, this position belonged to AC and AA genotypes of OCT1_rs622342 polymorphism. 24145224

2013

dbSNP: rs45539933
rs45539933
0.010 GeneticVariation BEFREE Indeed, several studies have reported that polymorphisms -3826A/G, -1766A/G and -112A/C in the promoter region, Ala64Thr in exon 2 and Met299Leu in exon 5 of UCP1 gene are possibly associated with obesity and/or DM2. 22790465

2012

dbSNP: rs1871922
rs1871922
0.010 GeneticVariation BEFREE In addition, the single-nucleotide polymorphism (SNP) rs1871922 located in the first intron of DM2 was genotyped. 21224892

2011

dbSNP: rs4986791
rs4986791
0.010 GeneticVariation BEFREE Two specific polymorphisms of toll-like receptor 4 (TLR4; Asp299Gly and Thr399Ile) have recently been identified either as candidate protector genes against DM2 and associated neuropathy or risk alleles for the manifestation of diabetic retinopathy. 21628510

2011

dbSNP: rs225014
rs225014
0.010 GeneticVariation BEFREE Our results indicate that in a case-control study, the homozygosity for D2 Thr92Ala polymorphism is associated with increased risk for DM2. 20566590

2010

dbSNP: rs1799945
rs1799945
0.010 GeneticVariation BEFREE We suggest that mutations C282Y and H63D in the HFE gene are not significant risk factors for the development of DM2 in Brazilian women. 19876870

2009

dbSNP: rs1800562
rs1800562
0.010 GeneticVariation BEFREE We suggest that mutations C282Y and H63D in the HFE gene are not significant risk factors for the development of DM2 in Brazilian women. 19876870

2009

dbSNP: rs4994
rs4994
0.010 GeneticVariation BEFREE Effect of the combination of the variants -75G/A APOA1 and Trp64Arg ADRB3 on the risk of type 2 diabetes (DM2). 17727676

2008

dbSNP: rs1458766475
rs1458766475
0.010 GeneticVariation BEFREE In the present study, we assessed the possible interactive effect of DM2 and E-selectin S128R polymorphism with respect to its predisposing individuals to CAD, using as a study model a population of 1,112 patients and 427 angiographed controls of Saudi origin. 17578587

2007

dbSNP: rs1466929132
rs1466929132
0.010 GeneticVariation BEFREE The pancreatic amyloid main component is a protein known as human islet amyloid polypeptide (hIAPP) or amylin, the most common mutation is the S20G in Asian population with a polymorphic frequency in DM2 Asian patients. 16950544

2007

dbSNP: rs5361
rs5361
0.010 GeneticVariation BEFREE In the present study, we assessed the possible interactive effect of DM2 and E-selectin S128R polymorphism with respect to its predisposing individuals to CAD, using as a study model a population of 1,112 patients and 427 angiographed controls of Saudi origin. 17578587

2007

dbSNP: rs16995309
rs16995309
0.010 GeneticVariation BEFREE In conclusion, the present data suggest that in a German Caucasian population the Pro387Leu polymorphism of the PTP-1B gene is not associated with DM-2 but may play a role in other metabolic phenotypes. 15715684

2005

dbSNP: rs750359414
rs750359414
0.010 GeneticVariation BEFREE In conclusion, the present data suggest that in a German Caucasian population the +62G-->A polymorphism of the resistin gene is associated with hypertension but not with DM-2. 16313475

2005

dbSNP: rs1800206
rs1800206
0.010 GeneticVariation BEFREE The data suggest that the PPARalpha polymorphism L162V might protect against the development of atherosclerosis or CHD in patients with DM-2. 15199365

2004