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rs12976445
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs12976445 SNP in miR-125a is associated with the risk of pneumonitis after in lung cancer patients undergoing the radiotherapy by regulating the expression of miR-125a and TGFB1.
|
30302847 |
2019 |
|
rs12976445
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The expression levels of miR‑125a and TGFβ in these samples were determined, and CC genotype samples demonstrated upregulated miR‑125a expression, and downregulated TGFβ protein and mRNA expression compared with samples carrying the minor allele, T. To further investigate the association between the rs12976445 polymorphism and the risk of pneumonitis in patients with lung cancer that received radiotherapy, 534 lung cancer patients diagnosed with pneumonitis and 489lung cancer patients without pneumonitis were recruited. rs12976445 was shown to be significantly associated with the risk of pneumonitis.
|
30132551 |
2018 |
|
rs1982073
|
|
|
0.020 |
GeneticVariation |
BEFREE |
TGF-β1 rs1982073 polymorphism contributes to radiation pneumonitis in lung cancer patients: a meta-analysis.
|
27470220 |
2016 |
|
rs1982073
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphism at rs1982073:T869C of the TGFbeta 1 gene is associated with the risk of radiation pneumonitis in patients with non-small-cell lung cancer treated with definitive radiotherapy.
|
19380441 |
2009 |
|
rs1695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
GSTP1 Ile105Val polymorphism might be associated with the risk of radiation pneumonitis among lung cancer patients in Chinese population: A prospective study.
|
29556330 |
2018 |
|
rs1061285
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After multiple comparison correction, RPS6KB2:rs10274, SMO:rs1061280, SMO:rs1061285 remained significantly associated with esophagitis, while processing gene DGCR8:rs720014, DGCR8:rs3757, DGCR8:rs1633445 remained significantly associated with pneumonitis.
|
26991123 |
2016 |
|
rs1633445
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After multiple comparison correction, RPS6KB2:rs10274, SMO:rs1061280, SMO:rs1061285 remained significantly associated with esophagitis, while processing gene DGCR8:rs720014, DGCR8:rs3757, DGCR8:rs1633445 remained significantly associated with pneumonitis.
|
26991123 |
2016 |
|
rs3757
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After multiple comparison correction, RPS6KB2:rs10274, SMO:rs1061280, SMO:rs1061285 remained significantly associated with esophagitis, while processing gene DGCR8:rs720014, DGCR8:rs3757, DGCR8:rs1633445 remained significantly associated with pneumonitis.
|
26991123 |
2016 |
|
rs720014
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After multiple comparison correction, RPS6KB2:rs10274, SMO:rs1061280, SMO:rs1061285 remained significantly associated with esophagitis, while processing gene DGCR8:rs720014, DGCR8:rs3757, DGCR8:rs1633445 remained significantly associated with pneumonitis.
|
26991123 |
2016 |
|
rs2868371
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Functional promoter variant rs2868371 of HSPB1 is associated with risk of radiation pneumonitis after chemoradiation for non-small cell lung cancer.
|
23374503 |
2013 |
|
rs2010963
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped three potentially functional VEGF single nucleotide polymorphisms (-460 T > C [rs833061], -634 G > C [rs2010963] and +936 C > T [rs3025039]) and estimated the associations of their genotypes and haplotypes with severe radiation pneumonitis (RP ≥grade 3) in 195 NSCLC patients.
|
22320189 |
2012 |
|
rs3025039
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped three potentially functional VEGF single nucleotide polymorphisms (-460 T > C [rs833061], -634 G > C [rs2010963] and +936 C > T [rs3025039]) and estimated the associations of their genotypes and haplotypes with severe radiation pneumonitis (RP ≥grade 3) in 195 NSCLC patients.
|
22320189 |
2012 |
|
rs1799983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, NOS3:rs1799983 displayed a protective effect with a 45% reduction in pneumonitis risk (HR:0.55, 95% CI:0.31-0.96).
|
20811626 |
2010 |
|
rs1217371203
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To clarify the mechanism underlying these observations we have developed a model of lung inflammation using adoptively transferred CD4(+) T cells expressing a Valpha11(+)Vbeta3(+) transgenic TCR specific for I-E(k) and moth cytochrome c. Treatment with Y100F-Ig inhibited the induction of lung eosinophilia in adoptively transferred mice.
|
11290768 |
2001 |
|
rs587782477
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To clarify the mechanism underlying these observations we have developed a model of lung inflammation using adoptively transferred CD4(+) T cells expressing a Valpha11(+)Vbeta3(+) transgenic TCR specific for I-E(k) and moth cytochrome c. Treatment with Y100F-Ig inhibited the induction of lung eosinophilia in adoptively transferred mice.
|
11290768 |
2001 |