NAT2, N-acetyltransferase 2, 10

N. diseases: 311; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma
0.340 Biomarker disease CTD_human The NAT2 fast acetylator and EPHX1 low-activity genotypes were positively associated with MM in the Italian study, while they were negatively associated with this malignancy in the Finnish one. 16697254 2006
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma
0.340 GeneticVariation disease BEFREE Conversely, MM risk was higher in Italian subjects carrying the NAT2 fast acetylator genotypes. 18838334 2009
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma
0.340 GeneticVariation disease BEFREE The individuals with combined GSTM1 and NAT2 defects had about a 4-fold risk of developing malignant mesothelioma compared to those with the GSTM1 gene and NAT2 fast acetylator genotype (OR = 3.6; 95% CI = 1.3-9.6). 7606714 1995
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma
0.340 GeneticVariation disease BEFREE The NAT2 fast acetylator and EPHX1 low-activity genotypes were positively associated with MM in the Italian study, while they were negatively associated with this malignancy in the Finnish one. 16697254 2006
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma
0.340 GeneticVariation disease BEFREE Individuals who lacked the GSTM1 gene and possessed a NAT2 slow-acetylator genotype had a risk of developing malignant and nonmalignant pulmonary disorders that was approximately fivefold greater than that observed for those who had the GSTM1 gene and a NAT2 fast-acetylator genotype (OR = 5.1; 95% CI = 1.6-17.6); these individuals had a fourfold increased risk of developing nonmalignant pulmonary disorders (OR = 4.1; 95% CI = 1.1-17.2) and an eightfold increased risk of developing malignant mesothelioma (OR = 7.8; 95% CI = 1.4-78.7) when compared with the same reference group. 8961976 1996