CDK2, cyclin dependent kinase 2, 1017

N. diseases: 270; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.090 Biomarker disease BEFREE Western Blot was performed to detect the expressions of AMPKα, Yap1, CCND1, CCNE1/2 and CDK2/4/6 in the metformin-treated BLCA cell lines. 31455378 2019
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.090 AlteredExpression disease BEFREE The aim of the present study was to investigate whether an increase in cyclin-dependent kinase 2 (CDK2) activity is involved in apoptosis of human bladder cancer T24 cells induced by isoliquiritigenin (ISL). 28693160 2017
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.090 Biomarker disease BEFREE To better define cytogenetic mechanisms of CDKN2 loss at 9p21 and of DBCCR1 loss at 9q33 in bladder cancer, and to determine correlation with p53 and pRb. 11410506 2001
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.090 GeneticVariation disease BEFREE These observations as well as the observation that bladder cancer is associated with deletions of CDKN2, a gene important in normal senescence, led us to examine normal urothelial cell response to H2O2. 10938379 2000
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.090 Biomarker disease BEFREE Level of retinoblastoma protein expression correlates with p16 (MTS-1/INK4A/CDKN2) status in bladder cancer. 10022125 1999
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.090 AlteredExpression disease BEFREE Different expression patterns of cyclin D1 and CDK2 indicate heterogeneity in the mechanisms of G1-->S transition deregulation in individual bladder tumors which may elicit differences in their biological and clinical behavior. 9738978 1998
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.090 GeneticVariation disease BEFREE Therefore, we applied gene-specific probes for CDKN2 and the interferon alpha gene (IFNA), also located at 9p21, to characterize further the genomic deletions at this locus in bladder cancer. 9171998 1997
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.090 Biomarker disease BEFREE p16 (CDKN2) is a major deletion target at 9p21 in bladder cancer. 8541841 1995
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm
0.090 PosttranslationalModification disease BEFREE Our data show a significant correlation (P = 0.00001, two-sided) between the absence of p16/CDKN2 expression and methylation of its 5' CpG island in bladder tumors, cell lines, and normal colon mucosa. 7553622 1995