CDK2, cyclin dependent kinase 2, 1017

N. diseases: 270; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia
0.090 Biomarker disease BEFREE Our data suggest that miR-638 regulates proliferation and myeloid differentiation by targeting CDK2 and may serve as a novel target for leukemia therapy or marker for AML diagnosis and prognosis. 25451924 2015
CUI: C0023418
Disease: leukemia
leukemia
0.090 Biomarker disease BEFREE In this study, we have used YAC probes encompassing the CDKN2 locus to analyze by fluorescence in situ hybridization patients with leukemia and lymphoma and translocations involving 9p in order to establish the CDKN2 status in relation to the karyotype. 9258663 1997
CUI: C0023418
Disease: leukemia
leukemia
0.090 Biomarker disease BEFREE The CDKN2 gene has been recently localized to a chromosomal region found to be deleted in leukemias and solid tumors. 8618438 1996
CUI: C0023418
Disease: leukemia
leukemia
0.090 Biomarker disease BEFREE Recently, two putative tumor suppressor gene(s) CDKN2 and MTS2 have been mapped to the 9p21 region, and shown to be deleted in a large number of tumors including leukemias, melanomas, bladder cancers and brain tumors. 8689637 1996
CUI: C0023418
Disease: leukemia
leukemia
0.090 PosttranslationalModification disease BEFREE These data show the coexistence of multiple genetic defects in childhood B-lineage ALL Cell lines with t(12;21) will facilitate the study of TEL-AML1 and AML1-TEL fusion proteins as well as TEL and CDKN2 gene inactivation in leukemia transformation and progression. 8704231 1996
CUI: C0023418
Disease: leukemia
leukemia
0.090 GeneticVariation disease BEFREE The cyclin-dependent kinase 4 (cdk4) inhibitor (p16INK4/MTS1/CDKN2) gene has been recently identified as a putative tumor suppressor gene because of the high frequency of homozygous deletion observed in numerous human tumor cell lines, including leukemias. 7630199 1995
CUI: C0023418
Disease: leukemia
leukemia
0.090 GeneticVariation disease BEFREE We did not observe any CDKN2 deletions in the 70 patients with chronic lymphoid leukaemias of B- or T-cell origin. 8547131 1995
CUI: C0023418
Disease: leukemia
leukemia
0.090 Biomarker disease BEFREE Involvement of CDKN2 (p16INK4A/MTS1) and p15INK4B/MTS2 in human leukemias and lymphomas. 7882348 1995
CUI: C0023418
Disease: leukemia
leukemia
0.090 GeneticVariation disease BEFREE Finally, of 10 cases of BCP-ALL that produced overt, transplantable leukemia in mice with severe combined immunodeficiency (SCID), seven showed biallelic CDKN2 deletions. 7849311 1995