Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
|
30224653 |
2018 |
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
This paper aims to investigate the association of 17 polymorphisms within 7 genes involved in neurotransmission (COMT, HTR2A, PPP3CC, RORA, SIGMAR1, SIRT1, and SORBS3) and AD.
|
31096213 |
2019 |
Obesity
|
0.020 |
Biomarker
|
disease |
BEFREE |
Previously, we had shown increased methylation (5.0 to 24.4%) and decreased gene expression (fold change - 1.9) of <i>SORBS3</i> with obesity (BMI > 30 kg/m<sup>2</sup>) compared to lean controls.
|
28883895 |
2017 |
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Methylation at the BDNF, SORBS3 and APP genes in AD were the most consistently reported associations.
|
27973581 |
2016 |
Obesity
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
Specifically, sorbin and SH3 domain containing 3 (SORBS3) which codes for the adapter protein vinexin was significantly decreased in gene expression (fold change -1.9) and had nine DMCs that were significantly increased in methylation in obesity (methylation differences ranged from 5.0 to 24.4 %).
|
27437034 |
2016 |
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin-6 signaling in hepatocellular carcinoma.
|
27311882 |
2016 |
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Among the 10-gene signature, a cluster of 6 genes on 8p, (DLC1, CCDC25, ELP3, PROSC, SH2D4A, and SORBS3) were deleted in HCCs from patients with poor outcomes.
|
22202459 |
2012 |
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Vinexin β Ablation Inhibits Atherosclerosis in Apolipoprotein E-Deficient Mice by Inactivating the Akt-Nuclear Factor κB Inflammatory Axis.
|
28209562 |
2017 |
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Vinexin β Ablation Inhibits Atherosclerosis in Apolipoprotein E-Deficient Mice by Inactivating the Akt-Nuclear Factor κB Inflammatory Axis.
|
28209562 |
2017 |
Coronary Arteriosclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunoblot analysis showed that vinexin β expression is upregulated in the atherosclerotic lesions of both patients with coronary heart disease and hyperlipemic apolipoprotein E-deficient mice and is primarily localized in macrophages indicated by immunofluorescence staining.
|
28209562 |
2017 |
Coronary heart disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunoblot analysis showed that vinexin β expression is upregulated in the atherosclerotic lesions of both patients with coronary heart disease and hyperlipemic apolipoprotein E-deficient mice and is primarily localized in macrophages indicated by immunofluorescence staining.
|
28209562 |
2017 |
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Aberrant expression of vinexin and rhotekin in various cancers has been implicated to promote metastasis because of their functions in cell adhesion and signaling.
|
28118077 |
2017 |
Vascular inflammations
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Vinexin β deficiency attenuates atherogenesis primarily by suppressing vascular inflammation and inactivating Akt-nuclear factor κB signaling.
|
28209562 |
2017 |
Coronary Artery Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunoblot analysis showed that vinexin β expression is upregulated in the atherosclerotic lesions of both patients with coronary heart disease and hyperlipemic apolipoprotein E-deficient mice and is primarily localized in macrophages indicated by immunofluorescence staining.
|
28209562 |
2017 |
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
In addition, the chromosome 8p tumor suppressor genes Src homology 2 domain containing 4A (SH2D4A) and Sorbin and Src homology 3 domain containing 3 (SORBS3) together exerted greater inhibition of cell growth and clonogenicity compared to a single gene.
|
27311882 |
2016 |