|
Adenocarcinoma of lung (disorder)
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
We further show that ACK1 promotes the phosphorylation and nuclear accumulation of STAT3 in cultured cells and that the levels of ACK1 correlate positively with the levels of tyrosine phosphorylated STAT3 in primary lung adenocarcinoma (ADC) cells.
|
28739485 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Tissue microarray data on 210 Singaporean lung adenocarcinomas indicate that cytoplasmic ACK1 was significantly over-expressed relative to paired adjacent non-tumor tissue.
|
24461128 |
2014 |
|
Adenocarcinoma of lung (disorder)
|
0.320 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Eosinophilic esophagitis
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy.
|
23686771 |
2013 |
|
Ethylmalonic encephalopathy
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy.
|
23686771 |
2013 |
|
Infantile-onset mesial temporal lobe epilepsy with severe cognitive regression
|
0.300 |
GermlineCausalMutation
|
disease |
ORPHANET |
Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy.
|
23686771 |
2013 |
|
Liver neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors.
|
19233941 |
2009 |
|
Precancerous Conditions
|
0.300 |
Biomarker
|
group |
CTD_human |
Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors.
|
19233941 |
2009 |
|
Condition, Preneoplastic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors.
|
19233941 |
2009 |
|
Malignant neoplasm of liver
|
0.300 |
Biomarker
|
disease |
CTD_human |
Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors.
|
19233941 |
2009 |
|
Gastric Adenocarcinoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Endometrioid carcinoma ovary
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Ovarian Mucinous Adenocarcinoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
As an oncogenic kinase, recent studies have shown that ACK1 plays a critical regulatory role in the initiation and progression of tumors.
|
31772931 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Conversely, pharmacological inhibition by ACK1 inhibitor, (R)-9bMS mitigated CD44<sup>+</sup>PSA<sup>-/lo</sup> sphere formation, overcame resistance to radiation-induced cell death, induced significant apoptosis in PCSCs and inhibited CD44<sup>+</sup>PSA<sup>-/lo</sup> xenograft tumor growth in castrated mice suggesting dependency of PCSCs on ACK1 for survival.
|
29386546 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We demonstrate that knockdown of TNK2 expression can substantially suppress the invasiveness and proliferation advantage of TNBC cells in vitro and tumor formation in xenograft mouse models.
|
27902967 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We aimed to investigate ACK1 protein expression in colorectal mucosa with inflammation and neoplasm, and to evaluate its correlation with disease activity and severity.
|
27926694 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Ack1 tyrosine kinase is overexpressed in prostate cancer and promotes castrate resistant xenograft tumor growth and enhances androgen target gene expression and AR recruitment to enhancers.
|
25950519 |
2015 |
|
Smoking
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.
|
26053186 |
2015 |
|
Smoking Behaviors
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.
|
26053186 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Interestingly, ACK1 expression in "normal" tissue adjacent to tumour, but not tumour, was independently associated with poor overall and relapse-free survival.
|
24461128 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Oncogenicity of ACK1 is not only due to its ability to promote activation of critical pro-survival kinases and harmone receptors by phosphorylating at distinct tyrosine residues, but also by employing a similar mechanism to eliminate a tumor suppressor from cancer cells.
|
23597703 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It also provides a rationale to target ACK1 in combination with other chemotherapeutic drugs, such as EGFR inhibitors, to potentiate therapeutic action against resistant tumors.
|
20359967 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Two intracellular tyrosine kinases, Ack1 (activated cdc42-associated kinase) and Src, phosphorylate and enhance AR activity and promote prostate xenograft tumor growth in castrated animals.
|
20383201 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Amplification of the TNK2 gene in primary tumours correlates with poor prognosis.
|
18435854 |
2008 |