TNK2, tyrosine kinase non receptor 2, 10188

N. diseases: 59; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.040 AlteredExpression disease BEFREE Ack1 tyrosine kinase is overexpressed in prostate cancer and promotes castrate resistant xenograft tumor growth and enhances androgen target gene expression and AR recruitment to enhancers. 25950519 2015
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.040 Biomarker disease BEFREE Prostate tissue microarray analysis indicates that Ack1 Tyr284 phosphorylation correlates positively with disease progression and negatively with the survival of prostate cancer patients. 20623637 2010
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.040 AlteredExpression disease BEFREE These data suggest that specific tyrosine kinases phosphorylate AR at distinct sites and that dasatinib may exert antitumor activity in prostate cancer through inhibition of Ack1. 20383201 2010
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.040 Biomarker disease BEFREE We and others have recently shown involvement of activated Cdc42-associated tyrosine kinase Ack1 in advanced human prostate cancer. 17494760 2007