|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Although the expression of SPRY1 was low when compared with other tumors, SPRY1 was variably expressed in primary Ewing sarcoma tumors and higher expression levels were significantly associated with improved outcome in a large patient cohort.
|
27375017 |
2017 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Although such 'escape' from senescence is not sufficient to promote thyroid tumorigenesis in adult mice up to 5 months, the onset of Phosphatase and tensin homolog (Pten)-induced tumor formation is accelerated when Spry1 is concomitantly eliminated.
|
24270409 |
2014 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
These findings identify Spry1 as a candidate tumor-suppressor gene in MTC.
|
22158037 |
2012 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Frequent losses (>40%) observed encompassed tumor suppressor genes (SPRY1, NELL1, and ID4, inhibitor of DNA binding 4), transcriptional repressors (TXNIP, thioredoxin interacting protein), SKP2 (S-phase kinase-associated protein 2; ubiquitin ligase component), and an antagonist of NF-κB activation (PPARGC1A).
|
21385932 |
2011 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Sprouty1 (Spry1) is a negative regulator of fibroblast growth factor signaling with a potential tumor suppressor function in prostate cancer (PCa).
|
21826097 |
2011 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Moreover, silencing of SPRY1 caused regression of established ERMS tumors (but not ARMS tumors) formed in xenograft settings.
|
20068162 |
2010 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Expression profiling by qRT-PCR with species-specific primers revealed that induction of SPRY1 expression by 16 K hPRL occurs only in the (murine) endothelial compartment and not in the (human) tumor compartment.
|
20813052 |
2010 |
|
Prostate carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In tissue samples, SPRY1 expression levels were significantly lower in prostate cancer patients with PSA recurrence after surgical treatment (P = 0.0076) and JAG1 expression levels were significantly higher in Gleason sum (GS) 8-9 disease than in GS 5-6 (P = 0.0121).
|
24604720 |
2014 |
|
Prostate carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Four candidates (Decorin, SPARC, Spry-1, Tsukushi) were immunolocalised in human foetal prostate (weeks 14, 16, 19) and expression of Decorin was evaluated on a human prostate cancer tissue microarray.
|
22880013 |
2012 |
|
Prostate carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Spry1 is downregulated in human PCa, and Spry1 expression can markedly inhibit PCa proliferation in vitro.
|
21826097 |
2011 |
|
Prostate carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma.
|
16954433 |
2006 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
To understand Spry1 regulation of signaling events controlling breast cancer phenotype, we used lentiviral delivery of human Spry1 shRNAs to suppress Spry1 expression in MDA-MB-231, an established TNBC cell line.
|
26976794 |
2016 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
To understand Spry1 regulation of signaling events controlling breast cancer phenotype, we used lentiviral delivery of human Spry1 shRNAs to suppress Spry1 expression in MDA-MB-231, an established TNBC cell line.
|
26976794 |
2016 |
|
Malignant neoplasm of prostate
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In tissue samples, SPRY1 expression levels were significantly lower in prostate cancer patients with PSA recurrence after surgical treatment (P = 0.0076) and JAG1 expression levels were significantly higher in Gleason sum (GS) 8-9 disease than in GS 5-6 (P = 0.0121).
|
24604720 |
2014 |
|
Malignant neoplasm of prostate
|
0.030 |
Biomarker
|
disease |
BEFREE |
Four candidates (Decorin, SPARC, Spry-1, Tsukushi) were immunolocalised in human foetal prostate (weeks 14, 16, 19) and expression of Decorin was evaluated on a human prostate cancer tissue microarray.
|
22880013 |
2012 |
|
Malignant neoplasm of prostate
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Spry1 is downregulated in human PCa, and Spry1 expression can markedly inhibit PCa proliferation in vitro.
|
21826097 |
2011 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, we used yeast two-hybrid screening of breast cancer cDNA library to identify hSpry1 and HAX1 proteins as putative candidate proteins that interact with uPAR bait constructs.
|
20696135 |
2010 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, we used yeast two-hybrid screening of breast cancer cDNA library to identify hSpry1 and HAX1 proteins as putative candidate proteins that interact with uPAR bait constructs.
|
20696135 |
2010 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The consistent down-regulation of Spry1 and 2 in breast cancer and the experimental evidence using a dominant-negative hSpry2Y55F indicate that Spry proteins may actively maintain tissue integrity that runs amok when their expression is decreased below normal threshold levels.
|
15342396 |
2004 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The consistent down-regulation of Spry1 and 2 in breast cancer and the experimental evidence using a dominant-negative hSpry2Y55F indicate that Spry proteins may actively maintain tissue integrity that runs amok when their expression is decreased below normal threshold levels.
|
15342396 |
2004 |
|
Rheumatoid Arthritis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
MicroRNA-421 promotes the inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis by downregulating the SPRY1 expression.
|
31646548 |
2019 |
|
Atrial Fibrillation
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Compared to the Control rats, CIH rats showed higher atrial interstitial collagen deposition and AF inducibility, mRNA levels of miR-21, MMP-9, PI3K, AKT, and protein levels of ERK, p-ERK, MMP-9, NF-κB, p-NF-κB were significantly increased, whereas mRNA levels of Spry1, ERK, and protein levels of Spry1, PTEN, PI3K, AKT, p-AKT were significantly decreased.
|
30203914 |
2018 |
|
Atrial Fibrillation
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The results showed that TGF-β1 was highly expressed while Spry1 was lowly expressed in the models of human and canine with AF.
|
29096943 |
2018 |
|
Glioblastoma Multiforme
|
0.020 |
Biomarker
|
disease |
BEFREE |
Meta-Analysis and Experimental Validation Identified FREM2 and SPRY1 as New Glioblastoma Marker Candidates.
|
29734672 |
2018 |
|
Rheumatoid Arthritis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In conclusion,miR-338-5p promoted the proliferation, invasion and inflammatory reaction in SFs of rheumatoid arthritis by directly down-regulating SPRY1 expression..
|
28098403 |
2017 |