Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.380 AlteredExpression group BEFREE We show here that i) compared to normal prostate tissue, Notch1 expression is significantly reduced in a substantial fraction of human PCas while it is unaffected or even increased in others; ii) acute Notch activation both inhibits and induces process networks associated with prostatic neoplasms; iii) down-modulation of Notch1 expression and activity in immortalized normal prostate epithelial cells increases their proliferation potential, while increased Notch1 activity in PCa cells suppresses growth and tumorigenicity through a Smad3-dependent mechanism involving p21WAF1/CIP1; iv) prostate cancer cells resistant to Notch growth inhibitory effects retain Notch1-induced upregulation of pro-oncogenic genes, like EPAS1 and CXCL6, also overexpressed in human PCas with high Notch1 levels. 27384993 2016
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.380 AlteredExpression group LHGDN Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin modification. 18413741 2008
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.380 Biomarker group LHGDN Orphan nuclear receptor estrogen-related receptor-beta suppresses in vitro and in vivo growth of prostate cancer cells via p21(WAF1/CIP1) induction and as a potential therapeutic target in prostate cancer. 18071305 2008
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.380 Biomarker group LHGDN Downregulation of both p21/Cip1 and p27/Kip1 produces a more aggressive prostate cancer phenotype. 18583941 2008
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.380 AlteredExpression group LHGDN Marked gene transcript level alterations occur early during radical prostatectomy. 17448597 2008
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.380 PosttranslationalModification group LHGDN p21WAF1/CIP1 gene is inactivated in metastatic prostatic cancer cell lines by promoter methylation. 16276353 2005
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.380 Biomarker group CTD_human p53 Codon 72 and p21 codon 31 polymorphisms in prostate cancer. 15598783 2004
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.380 GeneticVariation group LHGDN CDKN1A and CDKN1B polymorphisms and risk of advanced prostate carcinoma. 12727815 2003
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.380 Biomarker group CTD_human CDKN1A and CDKN1B polymorphisms and risk of advanced prostate carcinoma. 12727815 2003
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.380 Biomarker group LHGDN p21 modulates threshold of apoptosis induced by DNA-damage and growth factor withdrawal in prostate cancer cells. 12151346 2002