Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Squamous cell carcinoma of esophagus
0.400 Biomarker disease BEFREE Genome-scale CRISPR activation screening identifies a role of ELAVL2-CDKN1A axis in paclitaxel resistance in esophageal squamous cell carcinoma. 31285951 2019
Squamous cell carcinoma of esophagus
0.400 GeneticVariation disease BEFREE Our findings suggest that LEDGF/p75 regulates the p21 expression in ESCC cells through interacting with STRE element implicated in polymorphism rs2395655 and the elevated p21 protein expression and rs2395655 GG genotype may serve as positive prognostic factors for ESCC patients. 30854807 2019
Squamous cell carcinoma of esophagus
0.400 Biomarker disease BEFREE The PPI network revealed that PTEN, TP53, MDM2, E2F1, PRMT5, MCM2, RB1, CDKN1A, SHAD7 and EZH2 may serve core roles within the network and associate with one another during the pathogenesis of ESCC. 29250158 2018
Squamous cell carcinoma of esophagus
0.400 AlteredExpression disease BEFREE Gene Set Enrichment Analysis revealed that genes associated with cell cycle biological processes, including the cancer suppressor gene cyclin-dependent kinase 1A (CDKN1A), were significantly associated with SBF2-AS1 in ESCC tissues. 29552140 2018
Squamous cell carcinoma of esophagus
0.400 AlteredExpression disease BEFREE Mechanistically, MT3-MMP negatively regulated proliferation, colony formation, and migration of ESCC cells, in association with cell cycle arrest at G1, due to up-regulation of p21(Cip1) and p27(Kip1) . 27292876 2016
Squamous cell carcinoma of esophagus
0.400 AlteredExpression disease BEFREE Immunohistochemistry assay was further performed to detect the P21 protein expression in ESCC specimens. 26932598 2016
Squamous cell carcinoma of esophagus
0.400 GeneticVariation disease BEFREE In the multiple genetic model, we found that the rs2395655 in CDKN1A is related with the risk of ESCC, and that the G allele increases the susceptibility to ESCC (OR: 1.364; 95% CI: 1.104-1.685). 24474449 2014
Squamous cell carcinoma of esophagus
0.400 GeneticVariation disease BEFREE P21(waf1/cip1) gene polymorphisms and possible interaction with cigarette smoking in esophageal squamous cell carcinoma in northeastern Iran: a preliminary study. 20433229 2010
Squamous cell carcinoma of esophagus
0.400 Biomarker disease BEFREE Stable transfection of Id-1 antisense expression vector to inhibit the expression of endogenous Id-1 in another ESCC cell line (HKESC-1) reversed the effects on MDM2 and p21Waf1/Cip1. 16506209 2006
Squamous cell carcinoma of esophagus
0.400 AlteredExpression disease BEFREE Deregulated p21(WAF1) overexpression impacts survival of surgically resected esophageal squamous cell carcinoma patients. 16122475 2005
Squamous cell carcinoma of esophagus
0.400 Therapeutic disease CTD_human Experimental gene therapy using p21Waf1 gene for esophageal squamous cell carcinoma by gene gun technology. 15375580 2004
Squamous cell carcinoma of esophagus
0.400 AlteredExpression disease BEFREE p21Waf1/Cip1 expression is a prognostic marker in curatively resected esophageal squamous cell carcinoma, but not p27Kip1, p53, or Rb. 10458687 1999
Squamous cell carcinoma of esophagus
0.400 AlteredExpression disease BEFREE Abnormalities of the tumor suppressor gene p53 protein and the expression of p21WAF1/CIP1 protein were analyzed by immunohistochemical techniques in 32 cases of gastric adenocarcinoma and 15 cases of esophageal squamous cell carcinoma. 9512119 1998