Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
To conclude, systemic p16 peptide administration decreased lung tumor development in a mouse metastatic BT model without severe adverse events, as assessed by blood analyses and histological evaluation.
|
30655885 |
2019 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
<b>Patients & methods:</b> Lung tumor tissue microarray (n = 163), immunohistochemical study of p16 and p53, and HPV <i>in-situ</i> hybridization were analyzed.
|
31157548 |
2019 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
The Contrasting Role of p16Ink4A Patterns of Expression in Neuroendocrine and Non-Neuroendocrine Lung Tumors: A Comprehensive Analysis with Clinicopathologic and Molecular Correlations.
|
26674347 |
2015 |
Lung Neoplasms
|
0.800 |
PosttranslationalModification
|
group |
BEFREE |
In multivariate analysis, p16 hypermethylation was more prevalent in lung tumours from male than female patients (P = 0.018) and in squamous cell carcinomas than in adenocarcinomas (P = 0.025).
|
22217548 |
2012 |
Lung Neoplasms
|
0.800 |
AlteredExpression
|
group |
BEFREE |
Western blot analysis showed that stromal cells of lung tumours were characterised by a statistically significantly lower expression level of the p16 protein as compared with that in normal lung stromal cells.
|
20407446 |
2010 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
CTD_human |
Implication of p16 inactivation in tumorigenic activity of respiratory epithelial cell lines and adenocarcinoma cell line established from plutonium-induced lung tumor in rat.
|
20135361 |
2010 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
Our analyses revealed a high frequency of aberrant hypermethylation of MTHFR, RASSF1A, and CDKN2A in lung tumors as compared with control blood samples, whereas no significant increase in methylation levels of GSTP1 and CDH1 was observed, consistent with the notion that aberrant DNA methylation occurs in a tumor-specific and gene-specific manner.
|
19118009 |
2009 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
RGD |
Dynamic changes in DNA methylation during multistep rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine.
|
19409458 |
2009 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
CTD_human |
DNA methylation markers and early recurrence in stage I lung cancer.
|
18337602 |
2008 |
Lung Neoplasms
|
0.800 |
PosttranslationalModification
|
group |
LHGDN |
Quantitative p16 and ESR1 methylation in the peripheral blood of patients with non-small cell lung cancer.
|
18949413 |
2008 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
LHGDN |
Retrospective analysis of the prognostic role of p16 protein inactivation in plasma in patients with locally advanced non-small cell lung cancer.
|
18243403 |
2008 |
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
The formation of lung tumors by these chemicals involved mutations in the K-ras cancer gene and loss of heterozygosity in the region of K-ras on distal chromosome 6, while alterations in p53 and p16 were implicated in brain tumorigenesis.
|
16860786 |
2007 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
LHGDN |
Effects of exogenous p16(ink4a) gene on biological behaviors of human lung cancer cells.
|
17393105 |
2007 |
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
BEFREE |
To further explore the molecular mechanisms between altered TSGs promoter methylation and overexpression of DNMTs protein, we performed a tissue chromatin-immunoprecipitation polymerase chain reaction assay for lung tumors and showed that the methylated FHIT, p16(INK4a) and RARbeta promoters were bound by both DNMT protein and methyl-CpG-binding protein 2.
|
17140695 |
2007 |
Lung Neoplasms
|
0.800 |
GeneticVariation
|
group |
LHGDN |
Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history.
|
17575133 |
2007 |
Lung Neoplasms
|
0.800 |
AlteredExpression
|
group |
BEFREE |
H1299 lung cancer cells, lacking Fhit, Wwox, p16(INK4a) and Rassf1a expression due to epigenetic modifications, were used to assess efficacy of epigenetically targeted protocols in suppressing growth of lung tumors, by injection of 5-aza-2-deoxycytidine (AZA) and trichostatin A (TSA) in nude mice with established H1299 tumors.
|
17019711 |
2007 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
LHGDN |
Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer.
|
17936562 |
2007 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
Based on the concordance of biomarkers in lung tumours and corresponding sputum, and the low prevalence in cancer-free individuals, we selected seven markers for a nested case-control study: microsatellite instability of D9S942; loss of heterozygosity of D9S286, D9S942, GATA49D12, and D13S170; and methylation of p16INK4a and RARbeta.
|
17973238 |
2007 |
Lung Neoplasms
|
0.800 |
PosttranslationalModification
|
group |
LHGDN |
p16INK4A and CDH13 hypermethylation in tumor and serum of non-small cell lung cancer patients.
|
16222700 |
2006 |
Lung Neoplasms
|
0.800 |
Biomarker
|
group |
BEFREE |
Here, we applied methylation-specific polymerase chain reaction to compare the frequencies of the methylated promoter of p16 and O6-methylguanine-DNA methyltransferase (MGMT) genes in lung tumors from 122 patients with non-small cell lung cancer, including 81 smokers and 41 never-smokers.
|
16533425 |
2006 |
Lung Neoplasms
|
0.800 |
AlteredExpression
|
group |
BEFREE |
Moreover, and consistent with p14ARF being a determinant of CHK2 phosphorylation in lung carcinogenesis, a strong correlation between p14ARF and phospho-CHK2 (Thr68) protein expression is observed in human lung tumors (P < 0.00006).
|
16705183 |
2006 |
Lung Neoplasms
|
0.800 |
AlteredExpression
|
group |
BEFREE |
A subset of the lung tumors (8/28) displayed reduced levels of p16(Ink4a) expression (P = 0.02).
|
16482519 |
2006 |
Lung Neoplasms
|
0.800 |
PosttranslationalModification
|
group |
LHGDN |
The reduced expression and aberrant methylation of p16(INK4a) in chromate workers with lung cancer.
|
16828922 |
2006 |
Lung Neoplasms
|
0.800 |
PosttranslationalModification
|
group |
LHGDN |
Here, we applied methylation-specific polymerase chain reaction to compare the frequencies of the methylated promoter of p16 and O6-methylguanine-DNA methyltransferase (MGMT) genes in lung tumors from 122 patients with non-small cell lung cancer, including 81 smokers and 41 never-smokers.
|
16533425 |
2006 |
Lung Neoplasms
|
0.800 |
PosttranslationalModification
|
group |
LHGDN |
Moreover, the reverse correlation between p16INK4a immunostaining and p16INK4a promoter hypermethylation was also only observed in nonsmoking female lung tumors.
|
15455389 |
2005 |