Pancreatic Neoplasm
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
This can have implications for screening and for the diagnosis of pancreatic neoplasms in carriers of germline CDKN2A mutations.
|
31261289 |
2019 |
Pancreatic Neoplasm
|
0.800 |
Biomarker
|
disease |
CTD_human |
Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.
|
26098869 |
2015 |
Pancreatic Neoplasm
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In this study, three patients who developed both melanoma and intraepithelial neoplasia of the pancreas were tested for CDKN2A mutations and deletions, and investigated for rare germline copy number variations (CNVs).
|
24984283 |
2014 |
Pancreatic Neoplasm
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In LSL-Kras(G12D)/Pdx-1-Cre/Ink4a/Arf(lox/+) mice, calorie restriction versus overweight- or obesity-inducing diet regimens decreased serum IGF-I, tumoral Akt/mTOR signaling, pancreatic desmoplasia, and progression to pancreatic ductal adenocarcinoma (PDAC), and increased pancreatic tumor-free survival.
|
23980075 |
2013 |
Pancreatic Neoplasm
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The INK4a-ARF locus plays a central role in the development of pancreatic tumors as evidenced by the fact that up to 98% of pancreatic tumor specimens harbored genetic alterations at the INK4a-ARF locus.
|
23727582 |
2013 |
Pancreatic Neoplasm
|
0.800 |
GeneticVariation
|
disease |
LHGDN |
Low prevalence of CDKN2A/ARF mutations among early-onset cancers of breast, pancreas and malignant melanoma in Poland.
|
18714178 |
2008 |
Pancreatic Neoplasm
|
0.800 |
Biomarker
|
disease |
LHGDN |
Genetic testing in familial melanoma: uptake and implications.
|
18613292 |
2008 |
Pancreatic Neoplasm
|
0.800 |
GeneticVariation
|
disease |
LHGDN |
Detecting low-abundance p16 and p53 mutations in pancreatic juice using a novel assay: heteroduplex analysis of limiting dilution PCRs.
|
17106238 |
2006 |
Pancreatic Neoplasm
|
0.800 |
Biomarker
|
disease |
LHGDN |
Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma.
|
15985168 |
2005 |
Pancreatic Neoplasm
|
0.800 |
AlteredExpression
|
disease |
LHGDN |
Restoration of protein synthesis in pancreatic cancer cells by trans-splicing ribozymes.
|
15336553 |
2004 |
Pancreatic Neoplasm
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity.
|
15309028 |
2004 |
Pancreatic Neoplasm
|
0.800 |
Biomarker
|
disease |
LHGDN |
INK4/ARF germline alterations in pancreatic cancer patients.
|
14679123 |
2004 |
Pancreatic Neoplasm
|
0.800 |
GeneticVariation
|
disease |
LHGDN |
Familial melanoma, pancreatic cancer and germline CDKN2A mutations.
|
15146471 |
2004 |
Pancreatic Neoplasm
|
0.800 |
Biomarker
|
disease |
BEFREE |
Delivery of ALSV-A-based RCAS vectors encoding either mouse polyoma virus middle T antigen (PyMT) or c-Myc to elastase-tv-a transgenic, Ink4a/Arf null mice induced the formation of pancreatic tumors.
|
14681205 |
2003 |
Pancreatic Neoplasm
|
0.800 |
Biomarker
|
disease |
BEFREE |
The p16INK4a-/retinoblastoma tumour-suppressive pathway has been shown to be involved in the development of near to all pancreatic neoplasms. p14ARF is another tumour suppressor located in the immediate neighbourhood of p16INK4a.
|
12610506 |
2003 |
Pancreatic Neoplasm
|
0.800 |
GeneticVariation
|
disease |
LHGDN |
High prevalence of the G101W germline mutation in the CDKN2A (P16(ink4a)) gene in 62 Italian malignant melanoma families.
|
11807902 |
2002 |
Pancreatic Neoplasm
|
0.800 |
Biomarker
|
disease |
BEFREE |
Experiments on subcutaneous pancreatic xenografts demonstrated the effectiveness of p16 in the inhibition of pancreatic tumor growth in vivo.
|
11687897 |
2001 |
Pancreatic Neoplasm
|
0.800 |
Biomarker
|
disease |
CTD_human |
Novel germline p16(INK4) allele (Asp145Cys) in a family with multiple pancreatic carcinomas. Mutations in brief no. 148. Online.
|
10627132 |
1998 |
Pancreatic Neoplasm
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
To directly investigate genetic alterations and expression of p16/MTS1 and p15/MTS2, this study surveyed pancreatic tumors.
|
8613012 |
1996 |
Pancreatic Neoplasm
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Pancreatic Neoplasm
|
0.800 |
Biomarker
|
disease |
HPO |
|
|
|
Pancreatic Neoplasm
|
0.800 |
GenomicAlterations
|
disease |
CGI |
|
|
|
Pancreatic Neoplasm
|
0.800 |
CausalMutation
|
disease |
CGI |
|
|
|