Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Squamous cell carcinoma of the head and neck
0.500 Biomarker disease BEFREE Heterogeneity of p16 immunohistochemistry and increased sensitivity of RNA in situ hybridization in cytology specimens of HPV-related head and neck squamous cell carcinoma. 31509355 2019
Squamous cell carcinoma of the head and neck
0.500 Biomarker disease BEFREE We summarize current biomarkers in order of clinical utility; p16 and human papillomavirus status remain the most important and validated biomarkers in HNSCC. 31573749 2019
Squamous cell carcinoma of the head and neck
0.500 Biomarker disease BEFREE Cyfra21-1 assay showed significant differences between tumors of different sites with prominent elevation being found in oropharyngeal carcinomas and between patients with p16 positive and p16 negative HNSCC (p=0.0242), being elevated in p16 positive tumors. 31519630 2019
Squamous cell carcinoma of the head and neck
0.500 AlteredExpression disease BEFREE In the clinical samples of HNSCC, high expression of TrkA and panTrk were more associated with oropharyngeal and p16 positive squamous cell carcinoma (SCC). 30360033 2019
Squamous cell carcinoma of the head and neck
0.500 AlteredExpression disease BEFREE We thus retrospectively determined the Ki-67 proliferation index and p16 expression status to assess the associations of these parameters with treatment outcomes of patients with unknown primary head and neck SCC. 30756227 2019
Squamous cell carcinoma of the head and neck
0.500 GeneticVariation disease BEFREE Samples from 27 formalin-fixed, paraffin-embedded HNSCC cases from the Emory University Hospital archives were stained using 18 individual RNA ISH probes for high-risk HPV (RNAscope 2.5 LS Probe ) on a Leica autostainer (Buffalo Grove, IL) and were compared with p16 IHC. 28777152 2019
Squamous cell carcinoma of the head and neck
0.500 Biomarker disease BEFREE Cytologic evaluation of p16 staining in head and neck squamous cell carcinoma in CytoLyt versus formalin-fixed material. 31600033 2019
Squamous cell carcinoma of the head and neck
0.500 PosttranslationalModification disease BEFREE The current study aimed to examine the association between head and neck squamous cell carcinoma (HNSCC) and infection with different human papillomavirus virus (HPV) subtypes, including analysis of promoter methylation of several genes (APC, CDKN2A, MGMT, CDH1 and TIMP3) and the correlation with their mRNA expression in tumours and surgical margins. 30624179 2019
Squamous cell carcinoma of the head and neck
0.500 Biomarker disease BEFREE The expression of PD-L1, PD-1, and P16 in HNSCC is significantly correlated. 31674884 2019
Squamous cell carcinoma of the head and neck
0.500 Biomarker disease BEFREE In multivariable analysis, aUPD at the CDKN2A region was a significant predictor of overall survival in the whole cohort and in patients with HPV-negative HNSCC. aUPD at specific regions in the genome influences clinical outcomes of HNSCC and may be beneficial for selection of personalized therapy to prolong survival in patients with this disease. 31734631 2019
Squamous cell carcinoma of the head and neck
0.500 Biomarker disease BEFREE The loss of p16 is a signature event in Human Papilloma Virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) that leads to increased Cyclin Dependent Kinase 4/6 (CDK) signaling. 31727874 2019
Squamous cell carcinoma of the head and neck
0.500 AlteredExpression disease BEFREE Expression of p16 in HPV+ve HNSCC is thought to mediate radiosensitivity via inhibition of cyclin-dependent kinase (CDK) 4/6. 31271827 2019
Squamous cell carcinoma of the head and neck
0.500 Biomarker disease BEFREE The impact of programmed death-ligand 1 (PD-L1) expression, CD8+ tumor-infiltrating lymphocytes (TILs), and p16 status in HNSCC is unclear and may vary according to ethnicity. 30666437 2019
Squamous cell carcinoma of the head and neck
0.500 AlteredExpression disease BEFREE The aim of the present study was to evaluate the prognostic and predictive impact of PTEN, cMET, and p16 expression in recurrent HNSCC. 30478503 2018
Squamous cell carcinoma of the head and neck
0.500 Biomarker disease BEFREE Using the US Veterans Affairs database, we analyzed 1448 patients with locoregionally advanced HNSCC and known p16 status diagnosed between 2005 and 2015 and treated with surgery, radiotherapy, or chemoradiotherapy. 29878161 2018
Squamous cell carcinoma of the head and neck
0.500 AlteredExpression disease BEFREE Differences in the prognosis of HPV16-positive patients with squamous cell carcinoma of head and neck according to viral load and expression of P16. 29043437 2018
Squamous cell carcinoma of the head and neck
0.500 Biomarker disease BEFREE CDKN2A Copy Number Loss Is an Independent Prognostic Factor in HPV-Negative Head and Neck Squamous Cell Carcinoma. 29670856 2018
Squamous cell carcinoma of the head and neck
0.500 PosttranslationalModification disease BEFREE Our findings indicate CDKN2A methylation is involved in the carcinogenesis, progression, and metastasis of HNSCC. 30355925 2018
Squamous cell carcinoma of the head and neck
0.500 AlteredExpression disease BEFREE We conclude that HPV-positive HNSCC are characterized by p16 overexpression and low scores for pRb, CyclinD1, and a low combined pRb/CyclinD1 score. 26657876 2017
Squamous cell carcinoma of the head and neck
0.500 AlteredExpression disease BEFREE Here, we performed genome-wide expression profiling of HNSCC which revealed significant downregulation of the TFIIA downstream target CDKN2A. 29097782 2017
Squamous cell carcinoma of the head and neck
0.500 AlteredExpression disease BEFREE RB1 alterations may have important prognostic implications, particularly in the context of high p16 expression, in both HPV-positive and HPV-negative HNSCC. 27859938 2017
Squamous cell carcinoma of the head and neck
0.500 Biomarker disease BEFREE Significant differences were found in IGF-1 serum concentrations between patients with p16 positive and p16 negative HNSCC (p=0.0062), with higher IGF-1 levels in p16 positive tumors, between low-grade and high-grade cancers (p=0.0323) only in larynx, with elevated IGF-1 concentrations associated with high-grade and between recurrent and non-recurrent HNSCC (p=0.0354), with lower IGF-1 levels in recurrent tumors. 28551677 2017
Squamous cell carcinoma of the head and neck
0.500 Biomarker disease BEFREE Whilst a combination of PCR-based DNA detection and p16 IHC is useful, the latter has excellent specificity, acceptable sensitivity and good predictive value for carriage of HPV in this population and should be used for prognostic evaluation and treatment planning of all HNSCC patients in South Asia, as in the Western world. 29178862 2017
Squamous cell carcinoma of the head and neck
0.500 Biomarker disease BEFREE Meta analysis: HPV and p16 pattern determines survival in patients with HNSCC and identifies potential new biologic subtype. 29196639 2017
Squamous cell carcinoma of the head and neck
0.500 Biomarker disease BEFREE To retrospectively review post-treatment (post-tx) FDG-PET/CT scans in patients with advanced head and neck squamous cell carcinoma (HNSCC) and known p16 status, treated with definitive (chemo)radiation (RT). 28091733 2017