TNIP1, TNFAIP3 interacting protein 1, 10318

N. diseases: 93; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 GeneticVariation disease BEFREE Patients with psoriasis with TT genotype of rs10036748 in TNIP1, with lower BMI, without arthritis will achieve a better response to MTX. 31020648 2019
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 Biomarker disease BEFREE Subdomains within the TNIP1 protein as well as how they interact with ubiquitin have not only been mapped but inflammatory cell- and tissue-specific consequences subsequent to their defective function are being recognized and related to human disease states such as lupus, scleroderma, and psoriasis. 30402506 2018
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 GeneticVariation disease BEFREE The association between tumor necrosis factor-alpha induced protein 3 interacting protein 1 (TNIP1) gene and psoriasis was confirmed in people with multiple ethnicities. 27364786 2016
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 GeneticVariation disease GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 Biomarker disease BEFREE Based on previous studies suggesting a role for TNIP1 in modulating cancer cell growth, we investigated its role in keratinocyte proliferation, which is clearly abnormal in psoriasis. 26046540 2015
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 GeneticVariation disease GWASCAT Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis. 25854761 2015
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 GeneticVariation disease GWASCAT Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms. 25574825 2015
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 GeneticVariation disease BEFREE Thus, our results suggest that TNFAIP3 (rs610604) and TNIP1 (rs17728338) polymorphisms confer increased risk of psoriasis and may play a vital role in its pathogenesis in our ethnic South Indian Tamils. 26738398 2015
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 AlteredExpression disease BEFREE Strong additive effects when combining HLA-C*06 with IL23A, IL23R, IL12B, NFKB1 or TNIP1 were restricted to the severe cohort, indicating that activation of these pathways may influence disease severity in psoriasis. 25789703 2015
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 Biomarker disease BEFREE In addition, we show that the MHC and TNIP1 regions are significantly different in patients with psoriasis onset before the age of 40 (type I) compared to after 40 years of age (type II). 25481369 2015
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 GeneticVariation disease BEFREE After our first psoriasis genome-wide association study, we designed a custom genotyping array to fine-map eight genome-wide significant susceptibility loci known at that time (IL23R, IL13, IL12B, TNIP1, MHC, TNFAIP3, IL23A and RNF114) enabling genotyping of 2269 single-nucleotide polymorphisms (SNPs) in the eight loci for 2699 psoriasis cases and 2107 unaffected controls of European ancestry. 25182136 2015
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 GeneticVariation disease BEFREE We further identified previously unreported pleiotropic alleles with opposing effects on atopic dermatitis and psoriasis risk in PRKRA and ANXA6/TNIP1. 25574825 2015
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 Biomarker disease BEFREE Thus, the data suggested that HCP5, TNIP1 and TNFAIP3 may play a role in common pathogenic of psoriasis in Chinese and confer risk factors for psoriasis in various ethnic populations. 25264125 2014
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 Biomarker disease BEFREE This study provides empirical evidence for the gene-environment interactions between TNIP1/ANXA6 and alcohol use, CSMD1 and cigarette smoking, highlighting the importance of gene-environment interactions in the pathogenesis of psoriasis. 23541940 2013
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 GeneticVariation disease GWASCAT Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. 23143594 2012
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 GeneticVariation disease GWASDB Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. 23143594 2012
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 AlteredExpression disease BEFREE A growing number of references have implicated TNIP1 through GWAS and expression studies in chronic inflammatory diseases such as psoriasis and rheumatoid arthritis, although TNIP1s exact role has yet been determined. 22542476 2012
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 Biomarker disease BEFREE These include TNFAIP3 and TNIP1, which has been implicated in association studies for RA, systemic lupus erythematosus, and psoriasis. 21362769 2011
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 Biomarker disease BEFREE Psoriasis and psoriatic arthritis fall into this disease spectrum, with the largest region of susceptibility coming from the MHC (most likely HLA-C, ie, C*06:02 although additional influences are also being implicated), and most of the other genetic susceptibility coming from genes involved in cytokine production, specifically genes in the Th17 pathway (IL-12B, IL-23A and IL-23R, the latter, like in AS, not seen in Asians), genes in the nuclear factor κB pathway (TNFAIP3 and TNIP1) and genes in the Th2 pathway (IL-4 and IL-13). 21339218 2011
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 GeneticVariation disease BEFREE We identified six new susceptibility loci associated with psoriasis in the Chinese study containing the candidate genes ERAP1, PTTG1, CSMD1, GJB2, SERPINB8 and ZNF816A (combined P < 5 × 10⁻⁸) and replicated one locus, 5q33.1 (TNIP1-ANXA6), previously reported (combined P = 3.8 × 10⁻²¹) in the European studies. 20953187 2010
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 GeneticVariation disease GWASDB Association analyses identify six new psoriasis susceptibility loci in the Chinese population. 20953187 2010
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 GeneticVariation disease BEFREE Recently, the results of multiple well-powered genome-wide association studies have identified several additional loci outside the major histocompatibility complex region associated with psoriasis risk, including three genes involved in interleukin (IL)-23 signaling (IL-23R, IL-23A, IL-12B), two genes that regulate nuclear factor-kappaB signaling (TNIP1, TNFAIP3), and two genes involved in the modulation of T-helper type 2 immune responses (IL-4, IL-13). 20480402 2010
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 Biomarker disease CTD_human A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. 20953190 2010
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 GeneticVariation disease BEFREE More recently, analysis of psoriasis genome-wide association studies in a PsA subgroup has also implicated IL23A, TNFAIP3, and TNIP1 genetic variants as conferring risk to PsA. 20875338 2010
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.500 GeneticVariation disease LHGDN Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. 19169254 2009