Asthma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
Red Blood Cell Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Respiratory Tract Diseases
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Childhood asthma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Headache
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A Genome-Wide Association Study Finds Genetic Associations with Broadly-Defined Headache in UK Biobank (N=223,773).
|
29397368 |
2018 |
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
Migraine Disorders
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
Migraine Disorders
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.
|
27322543 |
2016 |
Platelet mean volume determination (procedure)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
Migraine Disorders
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
|
23793025 |
2013 |
Migraine Disorders
|
0.100 |
GeneticVariation
|
group |
GWASDB |
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
|
23793025 |
2013 |
Platelet aggregation
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.
|
20526338 |
2010 |
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
miR-940 potentially promotes proliferation and metastasis of endometrial carcinoma through regulation of MRVI1.
|
31085718 |
2019 |
Endometrial Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
First, we assessed the expression of miR-940 and MRVI1 in EC tissues collected from The Cancer Genome Atlas (TCGA) database and EC cell lines. miR-940 was significantly overexpressed in EC tissues and cell lines, particularly in RL95-2 cells.
|
31085718 |
2019 |
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, forced expression of MRVI1 in miR-940 mimic transfected cells abolished the facilitation of miR-940 on cell proliferation, migration, and invasion of RL95-2 and KLE cells.
|
31085718 |
2019 |
Moyamoya Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The rs35857561 polymorphism in MRVI1 may be a genetic susceptibility factor for moyamoya in European patients with neurofibromatosis type 1.
|
30001348 |
2018 |
Neurofibromatosis 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The rs35857561 polymorphism in MRVI1 may be a genetic susceptibility factor for moyamoya in European patients with neurofibromatosis type 1.
|
30001348 |
2018 |
Coronary Artery Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
More recently, further genes in the pathway encoding the endothelial nitric oxide synthase, the phosphodiesterases 3A and 5A, and the inositol 1,4,5-trisphosphate receptor I-associated protein (IRAG), i.e., NOS3, PDE3A, PDE5A, and MRVI1, respectively, were likewise identified as CAD risk genes.
|
29601927 |
2018 |
Thrombosis
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
These findings reveal that interaction between IRAG and InsP3RI has a central role in NO/cGMP-dependent inhibition of platelet aggregation and in vivo thrombosis.
|
16990611 |
2007 |
leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
One new site, Mrvi1 was identified that was disrupted by MRV in two of the leukemias.
|
10321731 |
1999 |
Myeloid Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these data suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation.
|
10321731 |
1999 |
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Experiments are in progress to test whether Mrvi1 is a tumor suppressor gene.
|
10321731 |
1999 |