|
Brain Ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
On the whole, the findings of the present study confirm the effects of 'governor vessel‑unblocking and mind‑regulating' acupuncture therapy on cognitive dysfunction induced by brain ischemia in rats, and that the mechanisms underlying the effects of this treatment might be mediated through the inhibition of TOMM40 and TIMM17A synthesis, which can relieve mitochondrial dysfunction from the accumulation of Aβ.
|
30431067 |
2019 |
|
Acute myocardial infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We assessed the effects of eAE-HRS on myocardial injury and oxidative damage in the MI model of rats and detected the effects of eAE-HRS on the expressions of cardiac OGG1 and Tom40, Tom20, and Tim23.
|
30033489 |
2019 |
|
Primary Progressive Nonfluent Aphasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We report association of APOE and TOMM40 with behavioural variant frontotemporal dementia, and ARHGAP35 and SERPINA1 with progressive non-fluent aphasia.
|
28387812 |
2017 |
|
Familial lichen amyloidosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We confirm that variation in/near APOE/TOMM40 (P = 6 × 10(-14)) alters PCA risk, but with smaller effect than for typical AD (PCA: odds ratio [OR] = 2.03, typical AD: OR = 2.83, P = .0007).
|
26993346 |
2016 |
|
Hypertriglyceridemia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Multivariate logistic regression analysis with adjustment for age, gender and body mass index revealed that rs964184 of ZPR1 (P=5.1x10‑7; odds ratio, 1.37; dominant model), rs4845625 of IL6R (P=0.0019, odds ratio, 1.25; dominant model) and rs46522 of UBE2Z (P=0.0039, odds ratio, 1.19; dominant model) were significantly associated with hypertriglyceridemia, and that rs599839 of PSRC1 (P=0.0004, odds ratio, 0.70; dominant model) and rs2075650 of TOMM40 (P=0.0004, odds ratio, 1.43; dominant model) were significantly associated with hyper‑LDL‑cholesterolemia.
|
26238946 |
2015 |
|
nervous system disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
The loci that replicated (FDR < 5%) included APOE/TOMM40 (associated with Alzheimer's disease), CDKN2B/ANRIL (implicated in the regulation of cellular senescence), ABO (tags the O blood group), and SH2B3/ATXN2 (a signaling gene that extends lifespan in Drosophila and a gene involved in neurological disease).
|
26677855 |
2015 |
|
Hyper LDL cholesterolaemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Therefore, ZPR1, IL6R, and UBE2Z may be susceptibility loci for hypertriglyceridemia, whereas PSRC1 and TOMM40 may be such loci for hyper-LDL-cholesterolemia in Japanese individuals.
|
26238946 |
2015 |
|
Mental Depression
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that TOMM40 rs2075650 may be a risk factor for the development of depression characterized by reduced extraversion, impaired executive function, and decreased positive emotional recall, and reduced top-down cortical control during sad emotion processing.
|
24549102 |
2014 |
|
Depressive disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that TOMM40 rs2075650 may be a risk factor for the development of depression characterized by reduced extraversion, impaired executive function, and decreased positive emotional recall, and reduced top-down cortical control during sad emotion processing.
|
24549102 |
2014 |
|
Diabetes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that previous findings of an association of the TOMM40 short allele with better cognitive performance, independently from the APOE variant status, are pertinent to elderly with diabetes.
|
25044051 |
2014 |
|
Diabetes Mellitus
|
0.010 |
GeneticVariation
|
group |
BEFREE |
These results suggest that previous findings of an association of the TOMM40 short allele with better cognitive performance, independently from the APOE variant status, are pertinent to elderly with diabetes.
|
25044051 |
2014 |
|
Obesity
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
(2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI = 4.03 × 10(-05), pBMI corr = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI = 0.002, rs2075650 at TOMM40/APOE, pBMI = 0.024, rs3865444 at CD33, pBMI = 0.024).
|
24788522 |
2014 |
|
Depressed mood
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Our results suggest that TOMM40 rs2075650 may be a risk factor for the development of depression characterized by reduced extraversion, impaired executive function, and decreased positive emotional recall, and reduced top-down cortical control during sad emotion processing.
|
24549102 |
2014 |
|
Chronic Kidney Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Four polymorphisms in APOA5, TOMM40, and CETP were shown to be significantly associated with CKD risk, and a significant interaction between the two APOA5 SNPs and BMI on CKD risk was also demonstrated.
|
25311932 |
2014 |
|
Exudative age-related macular degeneration
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The TOMM40 rs2075650 polymorphism was not statistically significantly associated with the nAMD or PCV phenotype (p>0.05).
|
24146538 |
2013 |
|
Frontotemporal Lobar Degeneration
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genotype and allele distribution of the TOMM40 polymorphisms between the FTLD group and controls did not show any statistical difference.
|
23546992 |
2013 |
|
Polypoidal choroidal vasculopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The TOMM40 rs2075650 polymorphism was not statistically significantly associated with the nAMD or PCV phenotype (p>0.05).
|
24146538 |
2013 |
|
AURAL ATRESIA, CONGENITAL
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among 24 studies (4703 participants) of other genetic polymorphisms, there was preliminary evidence of an association with CAA of polymorphisms in the transforming growth factor β1 gene (two studies, 449 participants), translocase of outer mitochondrial membrane 40 gene (one study, 723 participants) and the complement component receptor 1 gene (one study, 544 participants).
|
23457231 |
2013 |
|
Hepatitis C
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Pleiotropy and allelic heterogeneity in the TOMM40-APOE genomic region related to clinical and metabolic features of hepatitis C infection.
|
22898894 |
2012 |
|
Primary Progressive Aphasia (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Inside this region of 16.3 kb, LD (r2 = 0.14) between TOMM40 (rs157590) and APOE (rs429358) was observed in PPA, but not in bvFTD and in controls.
|
22710912 |
2012 |
|
Behavioral variant of frontotemporal dementia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Inside this region of 16.3 kb, LD (r2 = 0.14) between TOMM40 (rs157590) and APOE (rs429358) was observed in PPA, but not in bvFTD and in controls.
|
22710912 |
2012 |
|
B-Cell Lymphomas
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In fact, Nectin-2 (NC-2); apolipoprotein E (APOE); glycoprotein carcinoembryonic antigen related cell adhesion molecule-16 (CEACAM-16); B-cell lymphoma-3 (Bcl-3); translocase of outer mitochondrial membrane 40 homolog (T0MM-40); complement receptor-1 (CR-l); APOJ or clusterin and C-type lectin domain A family-16 member (CLEC-16A); Phosphatidyl inositol- binding clathrin assembly protein gene (PICALM); ATP-bonding cassette, sub family A, member 7 (ABCA7); membrane spanning A4 (MSA4); CD2 associated protein (CD2AP); cluster of differentiation 33 (CD33); and ephrin receptor A1 (EPHA1) result in a genetic signature that might affect individual brain susceptibility to infection by the herpes virus family during aging, leading to neuronal loss, inflammation, and amyloid deposition.
|
21891868 |
2011 |
|
Optic Atrophy 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found increased expression of the mitochondrial fission genes Drp1 and Fis1 (fission 1) and decreased expression of the mitochondrial fusion genes Mfn1 (mitofusin 1), Mfn2 (mitofusin 2), Opa1 (optic atrophy 1) and Tomm40.
|
21459773 |
2011 |
|
Charcot-Marie-Tooth disease, Type 2A
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Charcot-Marie-Tooth disease type 2A (CMT2A) is an autosomal dominant axonal form of peripheral neuropathy caused by mutations in the mitofusin 2 gene (MFN2), which encodes a mitochondrial outer membrane protein that promotes mitochondrial fusion.
|
21285398 |
2011 |
|
Carotid Artery Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We found that two loci, chromosome 1p13.3 near CELSR2 and PSRC1 which contains rs646776, and 19q13.2 near TOMM40 and APOE which contains rs2075650, harbor risk alleles for CAAD.
|
19951432 |
2009 |