Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.310 Biomarker disease PSYGENET TOMM40 rs2075650 may represent a new candidate gene for vulnerability to major depressive disorder. 24549102 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.310 GeneticVariation disease BEFREE TOMM40 rs2075650 may represent a new candidate gene for vulnerability to major depressive disorder. 24549102 2014
CUI: C0276496
Disease: Familial Alzheimer Disease (FAD)
Familial Alzheimer Disease (FAD)
0.310 GeneticVariation disease BEFREE We investigated the association between TOMM40 rs10524523, age of onset, and memory performance in patients with the PSEN1 M146L mutation in a large familial Alzheimer's disease Calabrian kindred, with a wide variability of onset not attributable to APOE. 23792692 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.310 Biomarker disease PSYGENET TOMM40 rs2075650 may represent a new candidate gene for vulnerability to major depressive disorder. 24549102 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.310 GeneticVariation disease BEFREE TOMM40 rs2075650 may represent a new candidate gene for vulnerability to major depressive disorder. 24549102 2014
CUI: C0276496
Disease: Familial Alzheimer Disease (FAD)
Familial Alzheimer Disease (FAD)
0.310 Biomarker disease ORPHANET
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.300 Biomarker disease CTD_human c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma. 27602772 2016
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 Biomarker disease BEFREE Family history and TOMM40 '523 interactive associations with memory in middle-aged and Alzheimer's disease cohorts. 28549947 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation disease BEFREE The translocase of outer mitochondrial membrane 40 (TOMM40), which lies in linkage disequilibrium with apolipoprotein E (APOE), has received attention more recently as a promising gene in Alzheimer's disease (AD) risk. 28183529 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation disease GWASCAT We confirm that variation in/near APOE/TOMM40 (P = 6 × 10(-14)) alters PCA risk, but with smaller effect than for typical AD (PCA: odds ratio [OR] = 2.03, typical AD: OR = 2.83, P = .0007). 26993346 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation disease BEFREE APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans. 28672022 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 Biomarker disease BEFREE The loci that replicated (FDR < 5%) included APOE/TOMM40 (associated with Alzheimer's disease), CDKN2B/ANRIL (implicated in the regulation of cellular senescence), ABO (tags the O blood group), and SH2B3/ATXN2 (a signaling gene that extends lifespan in Drosophila and a gene involved in neurological disease). 26677855 2016
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 AlteredExpression disease BEFREE The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes. 24439168 2016
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation disease BEFREE To test for independent associations between two Alzheimer's disease-susceptibility gene loci--APOE ε and the TOMM40 '523' poly-T repeat--and white matter hyperintensities/cerebral microbleed burden in community-dwelling older adults. 26310205 2016
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 Biomarker disease BEFREE In hypothesis-driven tests, there was significant association between general cognitive function and four genes previously associated with Alzheimer's disease: TOMM40, APOE, ABCG1 and MEF2C. 25644384 2016
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation disease BEFREE The exceptions were TOMM40 SNPs, which were associated with AD even after correction for multiple comparisons. 26419733 2016
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation disease GWASDB ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. 24770881 2015
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation disease GWASDB Here, we performed a meta-analysis combining data of 4,569 individuals (2,540 cases and 2,029 healthy controls) derived from three publicly available GWAS in AD and replicated a broad genomic region (>248,000 bp) associated with the disease near the APOE/TOMM40 locus in chromosome 19. 24755620 2015
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation disease GWASCAT Here, we performed a meta-analysis combining data of 4,569 individuals (2,540 cases and 2,029 healthy controls) derived from three publicly available GWAS in AD and replicated a broad genomic region (>248,000 bp) associated with the disease near the APOE/TOMM40 locus in chromosome 19. 24755620 2015
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation disease BEFREE Here, we performed a meta-analysis combining data of 4,569 individuals (2,540 cases and 2,029 healthy controls) derived from three publicly available GWAS in AD and replicated a broad genomic region (>248,000 bp) associated with the disease near the APOE/TOMM40 locus in chromosome 19. 24755620 2015
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation disease BEFREE TOMM40 alterations in Alzheimer's disease over a 2-year follow-up period. 25201778 2015
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation disease GWASCAT ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. 24770881 2015
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 Biomarker disease BEFREE The effect of TOMM40 poly-T repeat lengths on age of onset and cerebrospinal fluid biomarkers in Finnish Alzheimer's disease patients. 25500937 2015
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation disease BEFREE Genetic polymorphisms in the APOE ɛ and TOMM40 '523' poly-T repeat gene loci have been associated with significantly increased risk of Alzheimer's disease. 25247594 2015
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.200 GeneticVariation disease GWASCAT F-box/LRR-repeat protein 7 is genetically associated with Alzheimer's disease. 26339675 2015