Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expressions of C/EBPα and PPAR-γ were both negatively related with FOXC1 in human HCC tissue.
|
31512996 |
2020 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that C/EBPα and eEF1A1 may play opposing roles in Sp1-regulating miR-122 transcription, and the eEF1A1 upregulation accompanied by C/EBPα downregulation in HCC may switch the regulatory functions of Sp1 and led to reduced miR-122 transcription.
|
31561740 |
2020 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CCAAT enhancer binding protein α (C/EBPα), as an important transcription factor involved in cell proliferation, differentiation and metabolism, was up-regulated in primary hepatocellular carcinoma (HCC) and predicted poorer prognosis.
|
31092334 |
2019 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Altered expression of C/EBPα and C/EBPβ occurs in many tumours including HCC. saRNAs are small double-stranded RNAs that enhance target gene expression at the transcriptional level.
|
30643190 |
2019 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
MTL-CEBPA is presently in Phase I clinical trials for hepatocellular carcinoma (HCC).
|
29886828 |
2018 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two cases (one nodule-in-nodule case and another case with closely attached HCC and HGDN) showed several overlapped driver mutations (CTNNB1 and CEBPA) and CNAs (losses of CDKN2A, RB1, and TP53) between HGDNs and HCCs, suggesting their roles in the early HCC development.
|
29949741 |
2018 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here we report that the human FBP1 gene is regulated by two liver-enriched transcription factors, CCAAT-enhancer binding protein-α (C/EBPα) and hepatocyte nuclear factor 4α (HNF4α) in human hepatoma HepG2 cells.
|
29566023 |
2018 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A bioinformatically directed nucleotide walk around the CEBPA gene identified an saRNA sequence that upregulates CEBPA mRNA 2.5-fold in human hepatocellular carcinoma cells.
|
28882451 |
2017 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We showed TSA induced SIRT7 gene transcription and only the HDAC3, but not its catalytic domain depleted mutant, interacted with C/EBPα to occupy the C/EBPα element and repressed SIRT7 gene in the hepatocellular carcinoma cells.
|
26704017 |
2016 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Intriguingly, miR-223 expression was suppressed by sulfatide in HCC in association with reduced recruitment of acetylated histone H3 and C/EBPα to the pre-miR-223 gene promoter, where monocytic leukemia zinc finger (MOZ) protein, a MYST-type histone acetyltransferase, lost its attachment.
|
24333181 |
2014 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
C/EBPα inhibits hepatocellular carcinoma by reducing Notch3/Hes1/p27 cascades.
|
23816696 |
2013 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Chronic administration of 2-acetylaminofluorene alters the cellular iron metabolism in rat liver.
|
21785164 |
2011 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No mutations were detected in the CEBPA gene in HCCs and cell lines.
|
20347819 |
2010 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Reduced expression of C/EBP alpha protein in hepatocellular carcinoma is associated with advanced tumor stage and shortened patient survival.
|
18663475 |
2009 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein alpha by phosphatidylinositol 3-kinase signaling cascade.
|
17363595 |
2007 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
CCAAT/enhancer binding protein alpha knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma.
|
16288022 |
2005 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Down-regulated expression of the CCAAT/enhancer binding protein alpha and beta genes in human hepatocellular carcinoma: a possible prognostic marker.
|
12680236 |
2003 |