Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 AlteredExpression disease BEFREE Information on the relationship between circulating cholesteryl ester transfer protein (CETP) levels and coronary heart disease (CHD) incidence (and also, therefore, acute coronary syndrome [ACS]) is conflicting. 31504738 2020
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 GeneticVariation disease BEFREE Results showed that subjects with CETP rs5882 genetic variant, AA&AG genotypes, had a higher risk of developing Coronary artery disease [OR: 2.1, 95% CI (1.2-4.1), p value = 0.015]. 30902787 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 Biomarker disease BEFREE Evidence from genetic studies that variants in the CETP gene were associated with higher blood HDL cholesterol, lower low-density lipoprotein cholesterol, and lower risk of coronary heart disease suggested that pharmacological inhibition of CETP may be beneficial. 30704580 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 Biomarker disease BEFREE Treatment with CETP inhibitors, either alone or in combination with statins, could provide another option for patients with coronary disease who require further reduction in LDL (low-density lipoprotein) and non-HDL-C. 29018035 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 GeneticVariation disease BEFREE Although drug trials with niacin and cholesteryl ester transfer protein inhibitors that substantially increase high-density lipoprotein-cholesterol (HDL-C) failed to reduce the risk of coronary heart disease, HDL protection of the cardiovascular system cannot be easily denied. 29304861 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 GeneticVariation disease BEFREE Relationship between CETP gene polymorphisms with coronary artery disease in Polish population. 30178218 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 Biomarker disease BEFREE CETP (Cholesteryl Ester Transfer Protein) Concentration: A Genome-Wide Association Study Followed by Mendelian Randomization on Coronary Artery Disease. 29728394 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 Biomarker disease BEFREE Cholesteryl Ester Transfer Protein Inhibitors as Agents to Reduce Coronary Heart Disease Risk. 29609759 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 GeneticVariation disease BEFREE Gender specific effect of CETP rs708272 polymorphism on lipid and atherogenic index of plasma levels but not on the risk of coronary artery disease: A case-control study. 30544452 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 GeneticVariation disease BEFREE Subsequent breakdown analysis by age showed that CETP rs4783961, MLXIPL rs35493868, and PON2 rs12704796 were significantly associated with CHD among individuals younger than 55 years of age (CETP rs4783961: χ2=8.966, df=1, p=0.011 by genotype; MLXIPL rs35493868: χ2=4.87, df=1, p=0.027 by allele; χ2=4.88, df=1, p=0.027 by dominant model; PON2 rs12704796: χ2=6.511, df=2, p=0.039 by genotype; χ2=6.210, df=1, p=0.013 by allele; χ2=5.03, df=1, p=0.025 by dominant model). 29848931 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 AlteredExpression disease BEFREE While exposing the polygenic architecture of circulating lipids and the underpinnings of dyslipidaemia, these genome-wide association studies (GWAS) have provided further evidence of the critical role that lipids play in coronary heart disease (CHD) risk, as indicated by the 2.7-fold enrichment for macrophage gene expression in atherosclerotic plaques and the association of 25 loci (such as PCSK9, APOB, ABCG5-G8, KCNK5, LPL, HMGCR, NPC1L1, CETP, TRIB1, ABO, PMAIP1-MC4R, and LDLR) with CHD. 29800275 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 Biomarker disease BEFREE Collectively, these clinical outcome trials do not support raising HDL cholesterol by inhibiting cholesteryl ester transfer protein, as a mechanism for improving cardiovascular outcomes, in the total population of subjects with coronary artery disease. 29630000 2018
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 Biomarker disease BEFREE CETP inhibitors did not improve clinical outcomes in large-scale clinical trials of unselected patients with coronary disease. 28126828 2017
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 GeneticVariation disease BEFREE Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. 28506971 2017
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 GeneticVariation disease BEFREE The objective of this meta-analysis was to evaluate the association of CETP C-629A polymorphism with CHD risk and lipid changes. 27791990 2017
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 GeneticVariation disease BEFREE Genetic variations of cholesteryl ester transfer protein and diet interactions in relation to lipid profiles and coronary heart disease: a systematic review. 29234452 2017
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 GeneticVariation disease BEFREE In this study, the AT04A anti-PCSK9 vaccine was evaluated for its therapeutic potential in ameliorating or even preventing coronary heart disease in the atherogenic APOE*3Leiden.CETP mouse model. 28637178 2017
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 GeneticVariation disease BEFREE The aim of this study was to examine the effects of the HDL-associated Taq1B (rs708272) SNP of cholesterol ester transfer protein (CETP) gene on serum LDL subfractions in patients with CHD. 27900488 2017
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 Biomarker disease BEFREE Association of Cholesteryl Ester Transfer Protein and Endothelial Nitric Oxide Synthase Gene Polymorphisms With Coronary Artery Disease in the Multi-Ethnic Malaysian Population. 25667236 2016
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 GeneticVariation disease BEFREE c.*84G>A Mutation in CETP Is Associated with Coronary Artery Disease in South Indians. 27768712 2016
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 GeneticVariation disease BEFREE Large prospective studies are required to investigate the relationships of CETP and apo E polymorphisms with lipids, BMI, and CHD susceptibility. 24402318 2015
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 Biomarker disease BEFREE Currently, it remains unresolved whether circulating CETP is causally associated with coronary heart disease (CHD). 25561046 2015
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 GeneticVariation disease BEFREE Our data suggest that the B2 allele is associated with higher concentrations of HDL-C and lower concentrations of CETP, which confer a protective effect on coronary artery disease. 25725138 2015
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 GeneticVariation disease BEFREE Association of cholesteryl ester transfer protein (CETP) gene polymorphism, high density lipoprotein cholesterol and risk of coronary artery disease: a meta-analysis using a Mendelian randomization approach. 25366166 2014
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.200 GeneticVariation disease BEFREE The present study specifically re-examines the potential modification of the association between alcohol consumption and CHD by the CETP TaqIB (rs708272) polymorphism in a sample including both men and women. 25288221 2014