Coronary heart disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Information on the relationship between circulating cholesteryl ester transfer protein (CETP) levels and coronary heart disease (CHD) incidence (and also, therefore, acute coronary syndrome [ACS]) is conflicting.
|
31504738 |
2020 |
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Results showed that subjects with CETP rs5882 genetic variant, AA&AG genotypes, had a higher risk of developing Coronary artery disease [OR: 2.1, 95% CI (1.2-4.1), p value = 0.015].
|
30902787 |
2019 |
Coronary heart disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Evidence from genetic studies that variants in the CETP gene were associated with higher blood HDL cholesterol, lower low-density lipoprotein cholesterol, and lower risk of coronary heart disease suggested that pharmacological inhibition of CETP may be beneficial.
|
30704580 |
2019 |
Coronary heart disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Treatment with CETP inhibitors, either alone or in combination with statins, could provide another option for patients with coronary disease who require further reduction in LDL (low-density lipoprotein) and non-HDL-C.
|
29018035 |
2018 |
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Although drug trials with niacin and cholesteryl ester transfer protein inhibitors that substantially increase high-density lipoprotein-cholesterol (HDL-C) failed to reduce the risk of coronary heart disease, HDL protection of the cardiovascular system cannot be easily denied.
|
29304861 |
2018 |
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Relationship between CETP gene polymorphisms with coronary artery disease in Polish population.
|
30178218 |
2018 |
Coronary heart disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
CETP (Cholesteryl Ester Transfer Protein) Concentration: A Genome-Wide Association Study Followed by Mendelian Randomization on Coronary Artery Disease.
|
29728394 |
2018 |
Coronary heart disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Cholesteryl Ester Transfer Protein Inhibitors as Agents to Reduce Coronary Heart Disease Risk.
|
29609759 |
2018 |
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Gender specific effect of CETP rs708272 polymorphism on lipid and atherogenic index of plasma levels but not on the risk of coronary artery disease: A case-control study.
|
30544452 |
2018 |
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Subsequent breakdown analysis by age showed that CETP rs4783961, MLXIPL rs35493868, and PON2 rs12704796 were significantly associated with CHD among individuals younger than 55 years of age (CETP rs4783961: χ2=8.966, df=1, p=0.011 by genotype; MLXIPL rs35493868: χ2=4.87, df=1, p=0.027 by allele; χ2=4.88, df=1, p=0.027 by dominant model; PON2 rs12704796: χ2=6.511, df=2, p=0.039 by genotype; χ2=6.210, df=1, p=0.013 by allele; χ2=5.03, df=1, p=0.025 by dominant model).
|
29848931 |
2018 |
Coronary heart disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
While exposing the polygenic architecture of circulating lipids and the underpinnings of dyslipidaemia, these genome-wide association studies (GWAS) have provided further evidence of the critical role that lipids play in coronary heart disease (CHD) risk, as indicated by the 2.7-fold enrichment for macrophage gene expression in atherosclerotic plaques and the association of 25 loci (such as PCSK9, APOB, ABCG5-G8, KCNK5, LPL, HMGCR, NPC1L1, CETP, TRIB1, ABO, PMAIP1-MC4R, and LDLR) with CHD.
|
29800275 |
2018 |
Coronary heart disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Collectively, these clinical outcome trials do not support raising HDL cholesterol by inhibiting cholesteryl ester transfer protein, as a mechanism for improving cardiovascular outcomes, in the total population of subjects with coronary artery disease.
|
29630000 |
2018 |
Coronary heart disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
CETP inhibitors did not improve clinical outcomes in large-scale clinical trials of unselected patients with coronary disease.
|
28126828 |
2017 |
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease.
|
28506971 |
2017 |
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The objective of this meta-analysis was to evaluate the association of CETP C-629A polymorphism with CHD risk and lipid changes.
|
27791990 |
2017 |
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations of cholesteryl ester transfer protein and diet interactions in relation to lipid profiles and coronary heart disease: a systematic review.
|
29234452 |
2017 |
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In this study, the AT04A anti-PCSK9 vaccine was evaluated for its therapeutic potential in ameliorating or even preventing coronary heart disease in the atherogenic APOE*3Leiden.CETP mouse model.
|
28637178 |
2017 |
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to examine the effects of the HDL-associated Taq1B (rs708272) SNP of cholesterol ester transfer protein (CETP) gene on serum LDL subfractions in patients with CHD.
|
27900488 |
2017 |
Coronary heart disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Association of Cholesteryl Ester Transfer Protein and Endothelial Nitric Oxide Synthase Gene Polymorphisms With Coronary Artery Disease in the Multi-Ethnic Malaysian Population.
|
25667236 |
2016 |
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
c.*84G>A Mutation in CETP Is Associated with Coronary Artery Disease in South Indians.
|
27768712 |
2016 |
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Large prospective studies are required to investigate the relationships of CETP and apo E polymorphisms with lipids, BMI, and CHD susceptibility.
|
24402318 |
2015 |
Coronary heart disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Currently, it remains unresolved whether circulating CETP is causally associated with coronary heart disease (CHD).
|
25561046 |
2015 |
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that the B2 allele is associated with higher concentrations of HDL-C and lower concentrations of CETP, which confer a protective effect on coronary artery disease.
|
25725138 |
2015 |
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association of cholesteryl ester transfer protein (CETP) gene polymorphism, high density lipoprotein cholesterol and risk of coronary artery disease: a meta-analysis using a Mendelian randomization approach.
|
25366166 |
2014 |
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The present study specifically re-examines the potential modification of the association between alcohol consumption and CHD by the CETP TaqIB (rs708272) polymorphism in a sample including both men and women.
|
25288221 |
2014 |