Hypercholesterolemia
|
0.500 |
Biomarker
|
disease |
BEFREE |
To characterize their effect on atherogenesis, APOE*3Leiden.CETP mice were fed a high cholesterol/high fat diet (WTD) or normal chow (NC) for 18 weeks.
|
31366894 |
2019 |
Hypercholesterolemia
|
0.500 |
Biomarker
|
disease |
BEFREE |
About 80 genes are associated with hypercholesterolemia but only pharmaceuticals that inhibit cholesteryl ester transfer protein (CETP), angiopoietin-related protein 3 (ANGPTL3), and apolipoprotein C-III (apoC-III) have recently been tested in clinical trials.
|
29356705 |
2018 |
Hypercholesterolemia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Like familial hypercholesterolaemia patients, our familial hypercholesterolaemia liver chimeric mice develop hypercholesterolaemia and a 'humanized' serum profile, including expression of the emerging drug targets cholesteryl ester transfer protein and apolipoprotein (a), for which no genes exist in mice.
|
26081744 |
2015 |
Hypercholesterolemia
|
0.500 |
Biomarker
|
disease |
BEFREE |
A vaccine targeted at CETP alleviates high fat and high cholesterol diet-induced atherosclerosis and non-alcoholic steatohepatitis in rabbit.
|
25486007 |
2014 |
Hypercholesterolemia
|
0.500 |
Biomarker
|
disease |
BEFREE |
We designed a four-week parallel controlled intervention on apolipoprotein E3 Leiden cholesteryl ester transfer protein (ApoE*3Leiden.CETP) transgenic mice with mild overweight and hypercholesterolemia.
|
21611179 |
2011 |
Hypercholesterolemia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HDL cholesterol levels in children with mild hypercholesterolemia: effect of consuming skim milk enriched with olive oil and modulation by the TAQ 1B polymorphism in the CETP gene.
|
20413969 |
2010 |
Hypercholesterolemia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Despite similar atherosclerosis development, E3L.CETP mice had lower HDL-cholesterol as compared to E3L-HC mice (-49%) indicating that the HDL-cholesterol lowering effect of CETP is unlikely to contribute to atherosclerosis development in this experimental setting.
|
19345354 |
2009 |
Hypercholesterolemia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genome-wide scan for interacting loci affecting human cholesteryl ester transfer protein-induced hypercholesterolemia in transgenic human cholesteryl ester transfer protein F2-intercross rats.
|
17620956 |
2007 |
Hypercholesterolemia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The effect of the apo E phenotype on plasma CETP activity and the hypolipidaemic efficacy of colestipol and lovastatin was studied in patients with type II a or II b hypercholesterolaemia.
|
10192749 |
1999 |
Hypercholesterolemia
|
0.500 |
Biomarker
|
disease |
BEFREE |
We have investigated liver LDL receptor mRNA expression in nontransgenic, human cholesteryl ester transfer protein (CETP) transgenic, and human apolipoprotein (Apo) B/CETP double transgenic mice fed a normal chow diet and a high fat, high cholesterol diet (HFHC).
|
9409281 |
1997 |
Hypercholesterolemia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Dietary hypercholesterolemia results in increased hepatic CETP gene transcription and higher plasma CETP levels.
|
8550828 |
1996 |
Hypercholesterolemia
|
0.500 |
Biomarker
|
disease |
BEFREE |
The influence of hypertriglyceridemia and CETP on the development of atherosclerotic lesions in the proximal aorta was assessed by feeding transgenic mice a high cholesterol diet for 16 wk.
|
7560101 |
1995 |
Hypercholesterolemia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
CETP gene expression is upregulated in response to increased dietary cholesterol or endogenous hypercholesterolemia.
|
7574481 |
1995 |
Hypercholesterolemia
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
Hypercholesterolemia
|
0.500 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|