CETP, cholesteryl ester transfer protein, 1071

N. diseases: 188; N. variants: 88
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.500 Biomarker disease BEFREE To characterize their effect on atherogenesis, APOE*3Leiden.CETP mice were fed a high cholesterol/high fat diet (WTD) or normal chow (NC) for 18 weeks. 31366894 2019
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.500 Biomarker disease BEFREE About 80 genes are associated with hypercholesterolemia but only pharmaceuticals that inhibit cholesteryl ester transfer protein (CETP), angiopoietin-related protein 3 (ANGPTL3), and apolipoprotein C-III (apoC-III) have recently been tested in clinical trials. 29356705 2018
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.500 AlteredExpression disease BEFREE Like familial hypercholesterolaemia patients, our familial hypercholesterolaemia liver chimeric mice develop hypercholesterolaemia and a 'humanized' serum profile, including expression of the emerging drug targets cholesteryl ester transfer protein and apolipoprotein (a), for which no genes exist in mice. 26081744 2015
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.500 Biomarker disease BEFREE A vaccine targeted at CETP alleviates high fat and high cholesterol diet-induced atherosclerosis and non-alcoholic steatohepatitis in rabbit. 25486007 2014
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.500 Biomarker disease BEFREE We designed a four-week parallel controlled intervention on apolipoprotein E3 Leiden cholesteryl ester transfer protein (ApoE*3Leiden.CETP) transgenic mice with mild overweight and hypercholesterolemia. 21611179 2011
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.500 GeneticVariation disease BEFREE HDL cholesterol levels in children with mild hypercholesterolemia: effect of consuming skim milk enriched with olive oil and modulation by the TAQ 1B polymorphism in the CETP gene. 20413969 2010
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.500 Biomarker disease BEFREE Despite similar atherosclerosis development, E3L.CETP mice had lower HDL-cholesterol as compared to E3L-HC mice (-49%) indicating that the HDL-cholesterol lowering effect of CETP is unlikely to contribute to atherosclerosis development in this experimental setting. 19345354 2009
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.500 Biomarker disease BEFREE Genome-wide scan for interacting loci affecting human cholesteryl ester transfer protein-induced hypercholesterolemia in transgenic human cholesteryl ester transfer protein F2-intercross rats. 17620956 2007
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.500 AlteredExpression disease BEFREE The effect of the apo E phenotype on plasma CETP activity and the hypolipidaemic efficacy of colestipol and lovastatin was studied in patients with type II a or II b hypercholesterolaemia. 10192749 1999
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.500 Biomarker disease BEFREE We have investigated liver LDL receptor mRNA expression in nontransgenic, human cholesteryl ester transfer protein (CETP) transgenic, and human apolipoprotein (Apo) B/CETP double transgenic mice fed a normal chow diet and a high fat, high cholesterol diet (HFHC). 9409281 1997
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.500 AlteredExpression disease BEFREE Dietary hypercholesterolemia results in increased hepatic CETP gene transcription and higher plasma CETP levels. 8550828 1996
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.500 Biomarker disease BEFREE The influence of hypertriglyceridemia and CETP on the development of atherosclerotic lesions in the proximal aorta was assessed by feeding transgenic mice a high cholesterol diet for 16 wk. 7560101 1995
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.500 AlteredExpression disease BEFREE CETP gene expression is upregulated in response to increased dietary cholesterol or endogenous hypercholesterolemia. 7574481 1995
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.500 Biomarker disease HPO
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.500 Biomarker disease GENOMICS_ENGLAND