|
Age related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The cholesteryl ester transfer protein risk variant (rs17231506) for AMD was in line with increased HDL levels (P = 7.7 × 10<sup>-7</sup>), but lipase C risk variants (rs2043085, rs2070895) were associated in an opposite way (P = 1.0 × 10<sup>-6</sup> and P = 1.6 × 10<sup>-4</sup>).
|
30315903 |
2019 |
|
Age related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We found that in Asian population, CETP rs3764261 (T allele; OR = 1.46; 95% CI: 1.28-1.665, <i>P</i> < 0.01), CETP rs2303790 (G allele; OR = 1.57; 95% CI: 1.258-1.96, <i>P</i> < 0.01), and ABCG1 rs57137919 (A allele; OR = 1.168; 95% CI: 1.016-1.343, <i>P</i> < 0.01) were significantly associated with PCV, and ABCG1 rs57137919 (A allele; OR = 1.208, 95% CI: 1.035-1.411, <i>P</i> < 0.01) has different effects in PCV and AMD.
|
29977615 |
2018 |
|
Age related macular degeneration
|
0.200 |
Biomarker
|
disease |
BEFREE |
Some genetic evidence suggests that HDL-cholesterol is a causal risk factor for AMD risk and that increasing HDL-cholesterol (particularly via CETP inhibition) will increase AMD risk.
|
28456421 |
2017 |
|
Age related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Associations of cholesteryl ester transfer protein (CETP) gene variants with predisposition to age-related macular degeneration.
|
28918250 |
2017 |
|
Age related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.
|
26691988 |
2016 |
|
Age related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our data suggested that the allele A in rs3764261 in CETP gene may be associated with a decreased risk of advanced AMD in Chinese population.
|
24498989 |
2015 |
|
Age related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis revealed that both CETP rs3764261 and LIPC rs10468017 polymorphisms were significantly associated with AMD risk.
|
26503844 |
2015 |
|
Age related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We find a strong association between CETP Asp442Gly (rs2303790), an East Asian-specific mutation, and increased risk of AMD (odds ratio (OR)=1.70, P=5.60 × 10(-22)).
|
25629512 |
2015 |
|
Age related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
After multivariate adjustment for age, sex, educational level, smoking, BMI, lipid-lowering medication use, cardiovascular disease and diabetes, and for all relevant genetic polymorphisms (ApoE2, ApoE4, CFH Y402H, ARMS2 A69S, LIPC rs10468017, LIPC rs493258, LPL rs12678919, ABCA1 rs1883025 and CETP rs3764261), higher HDL was significantly associated with an increased risk of early (OR = 2.45, 95%CI: 1.54-3.90; P = 0.0002) and any AMD (OR = 2.29, 95%CI: 1.46-3.59; P = 0.0003).
|
24608419 |
2014 |
|
Age related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A significant interaction between the CETP SNP rs3764261 and the CFH SNP rs800292 existed in both neovascular AMD and PCV, the rs800292 G allele conferring a significantly increased risk of the diseases only in individuals carrying the risk allele T of rs3764261.
|
24393350 |
2014 |
|
Age related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Seven new loci associated with age-related macular degeneration.
|
23455636 |
2013 |
|
Age related macular degeneration
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Seven new loci associated with age-related macular degeneration.
|
23455636 |
2013 |
|
Age related macular degeneration
|
0.200 |
Biomarker
|
disease |
BEFREE |
Suggestive associations were seen between AMD and the HDL pathway genes CETP and LPL.
|
21906714 |
2011 |