UTS2, urotensin 2, 10911

N. diseases: 115; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011847
Disease: Diabetes
Diabetes
0.060 Biomarker disease BEFREE The present study explores whether UII can regulate autophagy in the kidney, and its effect in diabetes. 27459313 2017
CUI: C0011847
Disease: Diabetes
Diabetes
0.060 GeneticVariation disease BEFREE Thr21Met (T21M) and Ser89Asn (S89N) polymorphisms of the UTS2 gene were associated with the risk of developing diabetes and DR. M21M genotype frequencies were high in PDR (8.9% in diabetic control vs. 54.6% in PDR, P = 0.0092) group. 22587369 2012
CUI: C0011847
Disease: Diabetes
Diabetes
0.060 Biomarker disease BEFREE Our results are compatible with a role for UII in glucose homeostasis and diabetes although we cannot rule out the possibility that PER3 gene may underlie the reported associations. 21559414 2011
CUI: C0011847
Disease: Diabetes
Diabetes
0.060 Biomarker disease BEFREE In humans, plasma U-II is elevated in heart failure, renal failure, liver disease, and diabetes. 17680191 2007
CUI: C0011847
Disease: Diabetes
Diabetes
0.060 AlteredExpression disease BEFREE However, elevated plasma UII levels also were reported in association with renal impairment and diabetes. 15492948 2004
CUI: C0011847
Disease: Diabetes
Diabetes
0.060 GeneticVariation disease BEFREE We surveyed SNPs in the UTS2 gene in 152 Japanese subjects with Type 2 diabetes mellitus and two control Japanese cohorts: one consisting of 122 elderly subjects who met stringent criteria for being non-diabetic, including being older than 60 years of age with no evidence of diabetes (HbA(1c)<5.6%), and another 268 subjects with normal glucose tolerance. 12830381 2003