|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Our findings identify CHI3L1 as a potential schizophrenia-susceptibility gene and suggest that the genes involved in the biological response to adverse environmental conditions are likely to play roles in the predisposition to schizophrenia.
|
17160890 |
2007 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Here we report that CHI3L1 SNPs, shown to be involved in the predisposition of schizophrenia, are not associated with rheumatoid arthritis.
|
20300754 |
2011 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Allelic expression imbalance of the schizophrenia susceptibility gene CHI3L1: evidence of cis-acting variation and tissue specific regulation.
|
21642896 |
2011 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the genetic variants in the CHI3L1 gene have ethnic heterogeneity and confer a susceptibility to schizophrenia in Asian populations.
|
20051317 |
2010 |
|
Glioblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Taken together our data suggest that the variant allele (-131C-->G) of CHI3L1 promoter has no significant impact on survival and is not a prognostic factor for glioblastoma.
|
19255724 |
2009 |
|
Glioblastoma Multiforme
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Taken together our data suggest that the variant allele (-131C-->G) of CHI3L1 promoter has no significant impact on survival and is not a prognostic factor for glioblastoma.
|
19255724 |
2009 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A Kaplan-Meier survival curve showed that significant differences in 5-year survival rates were found in AD patients in different genotypes of CHI3L1 rs4950928 C>G and rs10399931 C>T.
|
30223258 |
2019 |
|
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Circulating YKL-40 level, but not CHI3L1 gene variants, is associated with atherosclerosis-related quantitative traits and the risk of peripheral artery disease.
|
25486056 |
2014 |
|
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In T2DM patients without established cardiovascular disease, novel indices of vascular inflammation (NGAL and YKL-40) were associated with subclinical atherosclerosis (arterial stiffness) but also with adverse clinical prognosis.
|
29288632 |
2018 |
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IL-1 stimulation of OA FLS did not affect methylation of LINE1 sites but led to demethylation of a CHI3L1 locus that is hypomethylated in RA FLS.
|
23277489 |
2013 |
|
Rheumatoid Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we report that CHI3L1 SNPs, shown to be involved in the predisposition of schizophrenia, are not associated with rheumatoid arthritis.
|
20300754 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the Tsukuba GWAS cohort, the C allele at rs946261 was significantly associated with reduced expression of CHI3L1 mRNA in the lung and with development of asthma (odds ratio (OR) 1.27; P = 0.036).
|
30940096 |
2019 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variations in CHI3L1 and CHIA have been associated with asthma risk.
|
19644363 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To explore whether interactions between high fungal exposure and common genetic variants in the two chitinases in humans, CHIT1 and CHIA, and the chitinase 3-like 1 gene, CHI3L1, are associated with severe asthma exacerbations and other asthma-related outcomes.
|
20538957 |
2010 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To study the interactions of the Chitinase 3-Like-1 functional promoter SNP rs4950928 and its role on asthma exacerbations in a population of children and young adults with asthma.
|
21530869 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of the present study was to investigate the association of common variation in the CHI3L1 locus with asthma, atopy and lung function in a large population-based sample of adults.
|
19568425 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After stratified according to ethnicity, CHI3L1 rs4950928 variant was associated with decreased asthma risk in Caucasians (GG + GC vs. CC: OR = 0.621, 95% CI = 0.484-0.797, P = 0.000; GC vs. CC: OR = 0.612, 95% CI = 0.470-0.796, P = 0.000; G vs. C: OR = 0.696, 95% CI = 0.567-0.856, P = 0.001).
|
29233108 |
2017 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, it has been reported that rs10399931 (-329 G/A) of CHI3LI contributes to the inter-individual plasma YKL-40 levels in patients with sarcoidosis, and that rs4950928 (-131 C/G) is a susceptibility polymorphism for asthma and a decline in lung function.
|
19421404 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Plasma YKL-40 levels were examined in relation to CHI3L1 rs4950928 genotype and clinical characteristics including Asthma Predictive Index, medication use, time spent with respiratory symptoms, atopic status, and blood leukocytes.
|
27732738 |
2017 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In contrast to the promoter SNP rs4950928, the intronic SNP rs12141494 in CHI3L1 is associated with asthma severity, lung function, and YKL-40 expression in the blood and airway.
|
25592985 |
2015 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that the CHI3L1 polymorphisms rs1538372 and rs10399931 can be used as genetic markers for predicting asthma risk in the Taiwanese population.
|
25056157 |
2014 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In T2DM patients without established cardiovascular disease, novel indices of vascular inflammation (NGAL and YKL-40) were associated with subclinical atherosclerosis (arterial stiffness) but also with adverse clinical prognosis.
|
29288632 |
2018 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Circulating YKL-40 level, but not CHI3L1 gene variants, is associated with atherosclerosis-related quantitative traits and the risk of peripheral artery disease.
|
25486056 |
2014 |
|
Malignant neoplasm of breast
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), chitinase-3-like protein 1 (CHI3L1), and vitamin D receptor (VDR) genes are implicated in breast carcinogenesis; however, the influence of their epistatic effects on BC susceptibility has not yet been studied.
|
30309792 |
2019 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
CHI3L1 rs4950928 genotype was associated with plasmaYKL-40 levels, but not with risk of any cancer category.
|
26095694 |
2015 |