Schizophrenia
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|
Schizophrenia
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 7
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
|
|
|
Delusions
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Hallucinations
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Negativism
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Social and occupational deterioration
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Hyper-IgM Immunodeficiency Syndrome, Type 1
|
0.050 |
Biomarker
|
disease |
BEFREE |
Unlike some other X-linked defects where extreme Lyonization may lead to disease, a small population of cells expressing the wild-type gp39 is sufficient to maintain normal humoral immunity and prevent the clinical symptoms of X-HIM.
|
7518839 |
1994 |
Hyper-IgM Immunodeficiency Syndrome, Type 1
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that a defect in gp39 is the basis of X-linked HIM.
|
7678782 |
1993 |
Hyperimmunoglobulin M syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that a defect in gp39 is the basis of X-linked HIM.
|
7678782 |
1993 |
Degenerative polyarthritis
|
0.350 |
Biomarker
|
disease |
BEFREE |
To evaluate the possible utility of YKL-40 in the assessment of joint disease, we measured YKL-40 in serum and SF of 49 patients with various forms of inflammatory and degenerative joint disease and in the serum of 50 normal adults.
|
8220933 |
1993 |
Arthropathy
|
0.040 |
Biomarker
|
group |
BEFREE |
The YKL-40 level in serum was significantly higher (P < 0.001) in the patients compared to the normal adults, but there was no difference in serum YKL-40 between the patients with inflammatory joint diseases and OA.
|
8220933 |
1993 |
Osteosarcoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We report the development of the first radioimmunoassay for YKL-40, a M(r) = 40 kDa protein which is secreted at high levels by human synovial cells and articular cartilage chondrocytes, and by the human osteosarcoma cell line MG63.
|
8220933 |
1993 |
Osteosarcoma of bone
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We report the development of the first radioimmunoassay for YKL-40, a M(r) = 40 kDa protein which is secreted at high levels by human synovial cells and articular cartilage chondrocytes, and by the human osteosarcoma cell line MG63.
|
8220933 |
1993 |
Childhood Osteosarcoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We report the development of the first radioimmunoassay for YKL-40, a M(r) = 40 kDa protein which is secreted at high levels by human synovial cells and articular cartilage chondrocytes, and by the human osteosarcoma cell line MG63.
|
8220933 |
1993 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neither the protein nor mRNA for HC gp-39 was detectable in normal newborn or adult human articular cartilage obtained at surgery, while mRNA for HC gp-39 was detectable both in synovial specimens and in cartilage obtained from patients with rheumatoid arthritis.
|
8245017 |
1993 |
Psoriasis
|
0.050 |
Biomarker
|
disease |
BEFREE |
These findings suggest a functional role of CD40 on KC in inflammatory skin disorders such as psoriasis and could make a therapeutic intervention by disrupting the CD40/gp39 pathway an approach to consider in these inflammatory skin diseases.
|
8898941 |
1996 |
Dermatologic disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
These findings suggest a functional role of CD40 on KC in inflammatory skin disorders such as psoriasis and could make a therapeutic intervention by disrupting the CD40/gp39 pathway an approach to consider in these inflammatory skin diseases.
|
8898941 |
1996 |
Hyper-IgM Immunodeficiency Syndrome, Type 1
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
The molecular defect in X-linked hyper-IgM syndrome has been shown to reside in the gene encoding the T-cell activation protein gp39 (CD40L, TRAP).
|
9371254 |
1994 |
Hyper-IgM Immunodeficiency Syndrome, Type 1
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
X-linked hyper-IgM syndrome (XHIM) is a severe congenital immunodeficiency caused by mutations in CD154 (CD40 ligand, gp39), the T cell ligand for CD40 on B cells.
|
9857288 |
1998 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages.
|
10073974 |
1999 |
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages.
|
10073974 |
1999 |
Gaucher Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Chitotriosidase and human cartilage gp-39 (HC gp-39) are members of the chitinase family of proteins and are expressed in lipid-laden macrophages accumulated in various organs during Gaucher disease.
|
10073974 |
1999 |
Meningitis
|
0.010 |
Biomarker
|
disease |
LHGDN |
In conclusion, high levels of YKL-40 in CSF are found in patients with purulent meningitis.
|
11986266 |
2002 |
Bacteremia
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Serum level of YKL-40 is elevated in patients with Streptococcus pneumoniae bacteremia and is associated with the outcome of the disease.
|
12069012 |
2002 |