|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Less is known about non-type 2 inflammation but blood neutrophils and YKL-40 may be higher in patients with evidence of non-type 2 asthma.
|
31652141 |
2020 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the Tsukuba GWAS cohort, the C allele at rs946261 was significantly associated with reduced expression of CHI3L1 mRNA in the lung and with development of asthma (odds ratio (OR) 1.27; P = 0.036).
|
30940096 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chitinase 3-like 1 protein (CHI3L1) (YKL-40 in humans and breast regression protein [BRP]-39 in mice) is required for optimal allergen sensitization and Th2 inflammation in various chronic inflammatory diseases including asthma.
|
30402955 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum periostin was high in both asthma and ACO, but not in COPD, whereas serum YKL-40 was high in both COPD and ACO, but not in asthma.
|
29981861 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CHI3L1 is a secreted glycoprotein and associated with inflammation, fibrosis, asthma, extracellular tissue remodeling and solid tumors.
|
30121622 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The chitinase-like protein YKL-40 has been associated with asthma and lung function in adults, but studies in children have yielded conflicting results.
|
31487401 |
2019 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The study had two parts.Study I (n = 115) was a one-year prospective cohort designed to explore the relationship of serum YKL-40 levels with inflammatory phenotypes of asthma at baseline, and during exacerbations.
|
31113430 |
2019 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Plasma YKL-40 levels were significantly elevated in patients with asthma compared to those in control subjects (<i>p</i> < .05).
|
31295039 |
2019 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A highly significant relation between serum levels of periostin and YKL40 and asthma severity, p value for each was <0.001.
|
29970479 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We sought to explore the plasma levels of biomarkers associated with asthma (periostin, TSLP and YKL-40), COPD (NGAL) and their possible correlation with lung function, the bronchodilator response and radiographic imaging in patients with asthma, COPD and with features of ACO.
|
29580282 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We sought to determine (1) whether methylation levels at CHI3L1 CpG sites mediate the association of CHI3L1 single nucleotide polymorphisms (SNPs) with YKL-40 levels in the blood and (2) whether these biomarkers (CHI3L1 SNPs, methylation profiles, and YKL-40 levels) are associated with asthma in early childhood.
|
28739286 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum YKL-40 may be used as a protein marker in classifying asthma severity by applying SPR technology as a reliable, label-free, highly sensitive, and cost-effective tool.
|
27616735 |
2017 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After stratified according to ethnicity, CHI3L1 rs4950928 variant was associated with decreased asthma risk in Caucasians (GG + GC vs. CC: OR = 0.621, 95% CI = 0.484-0.797, P = 0.000; GC vs. CC: OR = 0.612, 95% CI = 0.470-0.796, P = 0.000; G vs. C: OR = 0.696, 95% CI = 0.567-0.856, P = 0.001).
|
29233108 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The YKL-40 clusters are potentially useful for identification of individuals with severe or exacerbation-prone asthma.
|
29025889 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
YKL-40, also known as chitinase-like protein, has been shown to be related to various inflammatory conditions including atherosclerosis, diabetes, cancer, and asthma.
|
29028081 |
2017 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Plasma YKL-40 levels were examined in relation to CHI3L1 rs4950928 genotype and clinical characteristics including Asthma Predictive Index, medication use, time spent with respiratory symptoms, atopic status, and blood leukocytes.
|
27732738 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum chitotriosidase and YKL-40 were significantly elevated in patients with asthma and those with COPD compared with healthy control subjects.
|
26372680 |
2016 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
It has never been addressed whether SNPs in CHI3L1 and cord blood YKL-40 levels could already serve as potential biomarkers for milder forms of asthma.
|
27193312 |
2016 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The importance of CHI3L1 in initiation and development of asthma is not limited to its involvement in highly orchestrated events of inflammatory cytokines but further research is needed for further elucidation.
|
27438466 |
2016 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In contrast to the promoter SNP rs4950928, the intronic SNP rs12141494 in CHI3L1 is associated with asthma severity, lung function, and YKL-40 expression in the blood and airway.
|
25592985 |
2015 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
rDer p 1 significantly up-regulated the expression of PLA2G4A, PLA2G6, PLA2G15, CYSLTR1, LB4R2, PTGS1, PTGS2, FOXP1, GATA3, HDAC2, IREB2, PPARG, STAT4, TSLP and CHI3L1 genes in asthmatics in comparison to healthy subjects.
|
25634111 |
2014 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also found a significant correlation between YKL-40 serum level and spirometric indices even after adjusting the effects of other variables.We report for the first time in an Iranian population that YKL-40 may be a good diagnostic marker of asthma in serum.
|
24659163 |
2014 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that the CHI3L1 polymorphisms rs1538372 and rs10399931 can be used as genetic markers for predicting asthma risk in the Taiwanese population.
|
25056157 |
2014 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Following adjustment for CHI3L1 genotype, significantly greater levels of YKL-40 were found in children with therapy-resistant asthma than in children with controlled asthma.
|
23628340 |
2013 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further, a significant correlation with the genotypes in CHI3L1/YKL-40 was observed in the context of stress and asthma severity.
|
23190377 |
2013 |