CHI3L1, chitinase 3 like 1, 1116

N. diseases: 420; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Analysis of The Cancer Genome Atlas confirmed a relationship between glioma NF1 status and ENG and CHI3L1 in tumor samples. 29643433 2018
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE These results suggest that the STAT3 pathway is associated with the mTOR downstream pathway mediated by YKL-40 protein, and the combination therapy of the STAT3 inhibitor and rapamycin could be worth developing as a novel therapeutic approach against TMZ-resistant relapsed gliomas. 28031240 2017
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE We measured CHI3L1 expression with quantitative real time-polymerase chain reaction (qRT-PCR) in the cohort of 98 patients with different grade glioma: 10 grade I pylocytic astrocytomas, 30 grade II diffuse astrocytomas, 20 grade III anaplastic astrocytomas, and 38 grade IV astrocytomas (glioblastomas). 27121858 2016
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE The aim of this study was to investigate, in a small series of three GCAs, the expression of mesenchymal/radioresistance-associated biomarkers [such as chitinase-3-like protein 1 (YKL-40), hepatocyte growth factor receptor (c-Met), and caveolin 1 (Cav1)] that could contribute to the poor outcome associated with this glioma subgroup. 26845757 2016
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE Our gene analysis revealed that in general, YKL40 mRNA in glioma patients was over-expressed versus normal brain. 25629266 2014
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease CTD_human Thus, targeting the CHI3L1 molecule may be a potential therapeutic molecular target for gliomas. 20506295 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Taken together, these results suggest that CHI3L1 plays an important role in the regulation of malignant transformation and local invasiveness in gliomas. 20506295 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40. 21953450 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE Relative YKL-40 expression was compared with glioma class, key molecular alterations, and immunohistochemical markers via a series of Spearman rank correlations. 20224722 2010
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE YKL-40 may be an attractive target for glioma therapy. 20499402 2010
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE Our results suggest that in pediatric high-grade gliomas: (i) histological grading does not have strong prognostic significance, (ii) YKL-40 overexpression is less frequent than adult high-grade gliomas and does not correlate with a more aggressive behavior, (iii) TP53 mutations but not p53 expression may correlate with a more aggressive behavior, and (iv) IDH1 mutations are absent. 20174854 2010
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE CHI3L2, IL1B, PI3/elafin and CHI3L1, which encodes for YKL-40, a putative prognosticator for various diseases, including cancer, were strongly up-regulated in avascular glioma. 18092325 2008
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease LHGDN Even though TNF-alpha causes recruitment of p65 and p50 subunits of NF-kappaB to the YKL-40 promoter in all cell types, recruitment of histone deacetylases (HDAC)-1 and -2, and a consequent deacetylation of histone H3 at the YKL-40 promoter occurs only in glioma cells. 18708058 2008
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2. 18708058 2008
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease LHGDN Anaplastic glioma patients with no radiographic evidence of disease (n = 32 patients, 107 samples) also had a significantly lower level of YKL-40 compared with those patients with active tumor (n = 48 patients, 199 samples; P = 0.04). 17020973 2006
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease LHGDN YKL-40 staining provided a better class distinction of glioblastoma versus anaplastic oligodendroglioma than glial fibrillary acidic protein, the current standard immunohistochemical marker used to distinguish diagnostically challenging gliomas. 15788675 2005
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE Western blot analysis of glioma samples for YKL-40 protein levels revealed substantial elevation in approximately 65% of GBMs and undetectable levels in lower-grade gliomas (grade II and III) or normal brain tissue. 12154041 2002